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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Efnb2
ephrin B2
MGI:105097
98 phenotypes from 13 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Efnb2tm1.1Henk/Efnb2+
either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
normal reproductive system phenotype J:91491
Efnb2tm1.1Henk/Efnb2+
involves: 129 * CD-1
abnormal endolymph physiology J:116671
circling J:116671
decreased posterior semicircular canal size J:116671
decreased superior semicircular canal size J:116671
head bobbing J:116671
small endolymphatic duct J:116671
Efnb2tm1.1Henk/Efnb2tm1.1Henk
either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
abnormal angiogenesis J:91492
abnormal blood vessel morphology J:91492
abnormal cardiovascular development J:91492
abnormal heart morphology J:91492
abnormal vitelline vascular remodeling J:91492
abnormal vitelline vasculature morphology J:91492
decreased embryo size J:91492
embryonic growth retardation J:91492
embryonic lethality during organogenesis, complete penetrance J:91492
enlarged pericardium J:91492
Efnb2tm1.1Jwu/Efnb2tm1.1Jwu
Tg(Lck-cre)I540Jxm/0
B6.Cg-Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm
normal immune system phenotype J:178148
Efnb2tm1And/Efnb2tm1And
involves: 129S7/SvEvBrd
abnormal angiogenesis J:75288
abnormal cardinal vein morphology J:75288
abnormal endocardium morphology J:75288
abnormal heart ventricle morphology J:119151
abnormal myocardium layer morphology J:119151
abnormal vitelline vasculature morphology J:75288
absent myocardial trabeculae J:75288
normal cardiovascular system phenotype J:75288
embryonic growth retardation J:75288
embryonic lethality during organogenesis, complete penetrance J:75288
enlarged heart J:75288
Efnb2tm1And/Efnb2tm1And
involves: 129S7/SvEvBrd * C57BL/6
abnormal angiogenesis J:74909
abnormal anterior cardinal vein morphology J:74909
abnormal developmental vascular remodeling J:74909
abnormal heart looping J:74909
abnormal intersomitic vessel morphology J:74909
abnormal vitelline vasculature morphology J:74909
absent myocardial trabeculae J:74909
decreased embryo size J:74909
enlarged heart J:74909
Efnb2tm1And/Efnb2tm2And
Tg(Tek-cre)12Flv/0
involves: 129S7/SvEvBrd * C57BL/6
abnormal angiogenesis J:74909
abnormal developmental vascular remodeling J:74909
abnormal heart looping J:74909
abnormal intersomitic vessel morphology J:74909
abnormal vascular development J:74909
abnormal vitelline vasculature morphology J:74909
absent myocardial trabeculae J:74909
decreased embryo size J:74909
embryonic growth arrest J:74909
embryonic lethality during organogenesis, complete penetrance J:74909
enlarged heart J:74909
Efnb2tm1Henk/Efnb2+
either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
abnormal anogenital distance J:91491
abnormal penis morphology J:91491
abnormal septation of the cloaca J:91491
hypospadia J:91491
male infertility J:91491
splayed clitoris J:91491
Efnb2tm1Henk/Efnb2+
involves: 129 * CD-1
abnormal endolymph physiology J:116671
abnormal vestibular endolymph ionic homeostasis J:116671
abnormal vestibular endolymph physiology J:116671
circling J:116671
cleft palate J:173636
decreased posterior semicircular canal size J:116671
decreased superior semicircular canal size J:116671
head bobbing J:116671
small endolymphatic duct J:116671
Efnb2tm1Henk/Efnb2+
Not Specified
abnormal axon morphology J:176056
Efnb2tm1Henk/Efnb2tm1Henk
either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
abnormal anterior commissure pars posterior morphology J:91492
abnormal axon guidance J:91492
abnormal heart valve morphology J:91492
abnormal septation of the cloaca J:91491
abnormal urethra morphology J:91491
anal atresia J:91491
aortic valve hyperplasia J:91492
normal cardiovascular system phenotype J:91492
embryonic lethality between implantation and placentation, incomplete penetrance J:91492
enlarged aortic valve J:91492
enlarged pulmonary valve J:91492
hypospadia J:91491
neonatal lethality, complete penetrance J:91491, J:91492
persistent cloaca J:91491
pulmonary valve hyperplasia J:91492
splayed clitoris J:91491
thick aortic valve J:91492
thick mitral valve cusps J:91492
thick pulmonary valve J:91492
Efnb2tm1Henk/Efnb2tm1Henk
involves: 129 * CD-1
abnormal common crus morphology J:116671
abnormal semicircular canal morphology J:116671
cleft palate J:173636
decreased endolymph production J:116671
dilated endolymphatic duct J:116671
dilated endolymphatic sac J:116671
neonatal lethality, complete penetrance J:173636
tracheoesophageal fistula J:173636
Efnb2tm1Henk/Efnb2tm1Henk
Tbx4tm1(cre)Tmj/Tbx4+
involves: 129S1/Sv * 129X1/SvJ
normal nervous system phenotype J:176643
Efnb2tm1Henk/Efnb2tm2.1Henk
involves: 129 * CD-1
hypospadia J:173636
Efnb2tm1Henk/Efnb2tm3.1Henk
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal axon morphology J:176056
hypospadia J:173636
Efnb2tm1Kln/Efnb2tm1Kln
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal angiogenesis J:67296
abnormal cardinal vein morphology J:67296
abnormal intersomitic vessel morphology J:67296
abnormal neural crest cell migration J:67296
abnormal second pharyngeal arch morphology J:67296
absent pharyngeal arch arteries J:67296
absent second pharyngeal arch J:67296
normal embryo phenotype J:67296
embryonic growth retardation J:67296
embryonic lethality during organogenesis, complete penetrance J:67296
small second pharyngeal arch J:67296
Efnb2tm2.1Henk/Efnb2tm2.1Henk
involves: 129 * CD-1
normal digestive/alimentary phenotype J:173636
premature death J:173636
Efnb2tm2.1Kln/Efnb2tm2.1Kln
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
no abnormal phenotype detected J:67296
Efnb2tm2And/Efnb2tm2And
Tg(CAG-cre/Esr1*)1Egwa/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
abnormal angiogenesis J:157054
abnormal skin physiology J:157054
flaky skin J:157054
hyperkeratosis J:157054
normal integument phenotype J:157054
postnatal growth retardation J:157054
postnatal lethality, complete penetrance J:157054
retarded hair growth J:157054
small hair follicles J:157054
thick epidermis J:157054
thin hypodermis J:157054
Efnb2tm2Sor/Efnb2tm2Sor
involves: 129S4/SvJaeSor
embryonic lethality, complete penetrance J:115952
Efnb2tm2Sor/Efnb2tm2Sor
involves: 129S4/SvJaeSor * C57BL/6J
abnormal cranial neural crest cell migration J:143845
abnormal dorsal-ventral polarity of the somites J:143845
abnormal rostral-caudal patterning of the somites J:143845
abnormal somite development J:143845
abnormal trunk neural crest cell migration J:143845
decreased cranial neural crest cell number J:143845
embryonic lethality during organogenesis, complete penetrance J:143845
increased cranial neural crest cell apoptosis J:143845
small first pharyngeal arch J:143845
small trigeminal ganglion J:143845
Efnb2tm3.1Henk/Efnb2+
involves: 129S1/Sv * 129X1/SvJ
abnormal axon morphology J:176056
Efnb2tm3.1Henk/Efnb2tm3.1Henk
involves: 129S1/Sv * 129X1/SvJ * CD-1
normal digestive/alimentary phenotype J:173636
premature death J:173636
Efnb2tm3.1Kln/Efnb2tm3.1Kln
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal anterior cardinal vein morphology J:67296
abnormal intersomitic vessel morphology J:67296
abnormal vitelline vascular remodeling J:67296
distended pericardium J:67296
normal embryo phenotype J:67296
embryonic growth retardation J:67296
embryonic lethality during organogenesis, complete penetrance J:67296
small pharyngeal arch J:67296
Efnb2tm4Kln/Efnb2tm4Kln
Tg(Camk2a-cre)159Kln/0
involves: 129P2/OlaHsd * C57BL/6
normal behavior/neurological phenotype J:87398
normal nervous system phenotype J:87398
reduced long-term potentiation J:87398
Efnb2tm4Kln/Efnb2tm4Kln
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6
abnormal long-term depression J:87398
normal nervous system phenotype J:87398
Efnb2tm5Kln/Efnb2tm5Kln
involves: C57BL/6
chylothorax J:95885
postnatal lethality, complete penetrance J:95885

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory