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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ube3a
ubiquitin protein ligase E3A
MGI:105098
70 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(CAG-cre)13Miya/0
Ube3atm1Yelg/Ube3a+
involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J 		normal behavior/neurological phenotype J:222400
Tg(CAG-cre/Esr1*)5Amc/0
Ube3atm1Yelg/Ube3a+
involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J 		abnormal depression-related behavior J:222400
abnormal emotion/affect behavior J:222400
abnormal long-term potentiation J:222400
abnormal nest building behavior J:222400
audiogenic seizures J:222400
decreased locomotor activity J:222400
impaired coordination J:222400
Ube3aem1(IMPC)Hmgu/Ube3a+
C57BL/6N-Ube3aem1(IMPC)Hmgu/Ieg 		decreased food intake J:211773
decreased locomotor activity J:211773
decreased respiratory quotient J:211773
increased hematocrit J:211773
Ube3aem1(IMPC)Hmgu/Ube3aem1(IMPC)Hmgu
C57BL/6N-Ube3aem1(IMPC)Hmgu/Ieg 		abnormal seminal vesicle morphology J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased exploration in new environment J:211773
decreased food intake J:211773
decreased locomotor activity J:211773
decreased respiratory quotient J:211773
decreased vertical activity J:211773
hyperactivity J:211773
increased total body fat amount J:211773
Ube3aem1Mjz/Ube3a+
C57BL/6J-Ube3aem1Mjz 		abnormal motor learning J:338299
normal behavior/neurological phenotype J:338299
decreased social investigation J:338299
decreased thigmotaxis J:338299
normal embryo phenotype J:338299
normal growth/size/body region phenotype J:338299
increased locomotor activity J:338299
normal nervous system phenotype J:338299
Ube3aem1Mjz/Ube3aem1Mjz
C57BL/6J-Ube3aem1Mjz 		abnormal motor learning J:338299
normal behavior/neurological phenotype J:338299
decreased thigmotaxis J:338299
normal embryo phenotype J:338299
normal growth/size/body region phenotype J:338299
increased locomotor activity J:338299
increased vertical activity J:338299
normal nervous system phenotype J:338299
Ube3atm1.1Bdph/Ube3a+
7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
B6.Cg-Ube3atm1.1Bdph 7630403G23RikTg(Th-cre)1Tmd 		abnormal GABA-mediated receptor currents J:235694
abnormal operant conditioning behavior J:235694
Ube3atm1Alb/Ube3a+
involves: 129S7/SvEvBrd 		audiogenic seizures J:50811
tonic-clonic seizures J:50811
Ube3atm1Alb/Ube3a+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal brain wave pattern J:50811
abnormal cerebral cortex morphology J:50811
abnormal contextual conditioning behavior J:50811
abnormal dendrite morphology J:130068
abnormal emotion/affect behavior J:207499
abnormal gait J:50811
abnormal long-term potentiation J:207499
abnormal motor learning J:50811
abnormal nervous system electrophysiology J:50811
absence seizures J:50811
audiogenic seizures J:50811
decreased body weight J:50811
decreased locomotor activity J:207499
impaired contextual conditioning behavior J:207499
impaired coordination J:50811, J:207499
increased body weight J:207499
paternal imprinting J:50811, J:130068
reduced long-term potentiation J:50811
small cerebellum J:50811
tonic-clonic seizures J:50811
Ube3atm1Alb/Ube3a+
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal adrenaline level J:190050
increased dopamine level J:190050
increased serotonin level J:190050
Ube3atm1Alb/Ube3atm1Alb
involves: 129S7/SvEvBrd 		abnormal posture J:50811
audiogenic seizures J:50811
bradykinesia J:50811
limb grasping J:50811
postnatal growth retardation J:50811
postnatal lethality, incomplete penetrance J:50811
Ube3atm1Alb/Ube3atm1Alb
involves: 129S7/SvEvBrd * C57BL/6 		abnormal mammary gland growth during pregnancy J:99980
abnormal ovarian folliculogenesis J:99980
audiogenic seizures J:50811
decreased litter size J:99980
decreased oocyte number J:99980
decreased ovary weight J:99980
decreased prostate gland weight J:99980
decreased testis weight J:99980
decreased uterus weight J:99980
impaired luteinization J:99980
impaired sperm capacitation J:99980
oligozoospermia J:99980
postnatal lethality J:50811
reduced female fertility J:99980
reduced male fertility J:99980
Ube3atm1Jwf/Ube3a+
B6.129S4-Ube3atm1Jwf 		abnormal brain wave pattern J:102546
abnormal learning/memory/conditioning J:102546
abnormal motor capabilities/coordination/movement J:102546
abnormal nervous system electrophysiology J:95305
abnormal posture J:102546
abnormal sleep pattern J:102546
abnormal spatial learning J:75622
abnormal spike wave discharge J:75622, J:95305, J:102546
decreased brain weight J:75622
decreased locomotor activity J:102546
impaired contextual conditioning behavior J:75622
impaired coordination J:75622
Ube3atm1Yelg/Ube3a+
involves: 129P2/OlaHsd * 129S2/SvPasCrl 		abnormal depression-related behavior J:222400
abnormal emotion/affect behavior J:222400
abnormal nest building behavior J:222400
audiogenic seizures J:222400
decreased locomotor activity J:222400
impaired coordination J:222400
paternal imprinting J:222400
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory