Gpx3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gpx3
glutathione peroxidase 3
MGI:105102

16 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gpx3^{tm1b(KOMP)Wtsi}/Gpx3⁺ C57BL/6N-Gpx3^{tm1b(KOMP)Wtsi}/H	impaired glucose tolerance	J:211773
Gpx3^{tm1b(KOMP)Wtsi}/Gpx3^{tm1b(KOMP)Wtsi} C57BL/6N-Gpx3^{tm1b(KOMP)Wtsi}/H	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Gpx3^tm1Hjco/Gpx3^tm1Hjco involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal selenium level	J:159745
	decreased glutathione peroxidase activity	J:159745
	normal growth/size/body region phenotype	J:159745
	normal homeostasis/metabolism phenotype	J:159745
	normal renal/urinary system phenotype	J:159745
Gpx3^tm1Jlos/Gpx3⁺ B6N.Cg-Gpx3^tm1Jlos	decreased bleeding time	J:183744
Gpx3^tm1Jlos/Gpx3⁺ B6N.Cg-Gpx3^tm1Jlos	increased platelet aggregation	J:183744
Gpx3^tm1Jlos/Gpx3^tm1Jlos B6N.Cg-Gpx3^tm1Jlos	abnormal blood homeostasis	J:183744
	abnormal blood vessel physiology	J:183744
	decreased bleeding time	J:183744
	decreased cerebral infarct size	J:183744
	decreased susceptibility to ischemic brain injury	J:183744
	increased platelet aggregation	J:183744
	increased susceptibility to induced morbidity/mortality	J:183744
	increased susceptibility to induced thrombosis	J:183744

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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