Dusp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dusp1
dual specificity phosphatase 1
MGI:105120

65 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dusp1^{tm1(KOMP)Wtsi}/Dusp1^{tm1(KOMP)Wtsi} C57BL/6N-Dusp1^{tm1(KOMP)Wtsi}/Wtsi	decreased body weight	J:175295
	decreased circulating alanine transaminase level	J:175295
	decreased total body fat amount	J:175295
Dusp1^tm1Brv/Dusp1^tm1Brv B6.129S2-Dusp1^tm1Brv	abnormal superior cervical ganglion morphology	J:163234
Dusp1^tm1Brv/Dusp1^tm1Brv B6.129S2-Dusp1^tm1Brv	increased neuron apoptosis	J:163234
Dusp1^tm1Brv/Dusp1^tm1Brv C3.129S2-Dusp1^tm1Brv	abnormal chemokine secretion	J:164929
	increased granulocyte number	J:164929
	increased interleukin-1 beta secretion	J:164929
	increased interleukin-6 secretion	J:164929
	increased susceptibility to bacterial infection	J:164929
	lung inflammation	J:164929
	weight loss	J:164929
Dusp1^tm1Brv/Dusp1^tm1Brv involves: 129S2/SvPas	abnormal circulating alanine transaminase level	J:118832
	abnormal cytokine secretion	J:118832
	abnormal nitric oxide homeostasis	J:118832
	decreased systemic arterial systolic blood pressure	J:118832
	hypotension	J:118832
	increased blood urea nitrogen level	J:118832
	increased susceptibility to induced morbidity/mortality	J:118832
	lung inflammation	J:118832
	pulmonary edema	J:118832
	thick pulmonary interalveolar septum	J:118832
Dusp1^tm1Brv/Dusp1^tm1Brv involves: 129S2/SvPas * C57BL/6	abnormal cellular respiration	J:129718
	abnormal dendrite morphology	J:166927
	abnormal depression-related behavior	J:166162
	abnormal eating behavior	J:129718
	abnormal locomotor activation	J:129718
	abnormal muscle development	J:162340
	abnormal muscle regeneration	J:162340
	abnormal myoblast differentiation	J:162340
	decreased abdominal fat pad weight	J:129718
	decreased anxiety-related response	J:166162
	decreased body weight	J:129718
	decreased circulating cholesterol level	J:129718
	decreased circulating free fatty acids level	J:129718
	decreased circulating triglyceride level	J:129718
	decreased epididymal fat pad weight	J:129718
	decreased fat cell size	J:129718
	decreased liver weight	J:129718
	decreased myoblast proliferation	J:162340
	decreased skeletal muscle fiber diameter	J:162340
	decreased skeletal muscle fiber size	J:162340
	decreased susceptibility to age related obesity	J:129718
	decreased susceptibility to age-related hepatic steatosis	J:129718
	decreased susceptibility to diet-induced hepatic steatosis	J:129718
	decreased susceptibility to diet-induced obesity	J:129718
	decreased total body fat amount	J:129718
	normal homeostasis/metabolism phenotype	J:129718
	increased circulating interleukin-6 level	J:118833
	increased circulating interleukin-10 level	J:118833
	increased circulating tumor necrosis factor level	J:118833
	increased energy expenditure	J:129718
	increased hepatic glucose production	J:129718
	increased interleukin-6 secretion	J:118833
	increased respiratory quotient	J:129718
	increased susceptibility to endotoxin shock	J:118833
	increased susceptibility to xenobiotic induced morbidity/mortality	J:118833
	increased tumor necrosis factor secretion	J:118833
	small liver	J:129718
Dusp1^tm1Brv/Dusp1^tm1Brv involves: 129S2/SvPas * various	decreased body temperature	J:125919
	normal immune system phenotype	J:125919
	increased mast cell degranulation	J:125919
	increased susceptibility to type I hypersensitivity reaction	J:125919
Dusp1^tm1Lex/Dusp1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal chemokine level	J:126383
	abnormal innate immunity	J:126383
	abnormal interleukin level	J:126383
	increased circulating interferon-gamma level	J:126383
	increased circulating interleukin-6 level	J:126383
	increased circulating interleukin-10 level	J:126383
	increased circulating tumor necrosis factor level	J:126383
	increased prostaglandin level	J:126383
	increased susceptibility to endotoxin shock	J:126383
	increased susceptibility to induced arthritis	J:126383

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24