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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cxcr2
C-X-C motif chemokine receptor 2
MGI:105303
93 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
involves: 129S2/SvPas * C57BL/6 		decreased kidney weight J:113489
decreased spleen weight J:113489
normal immune system phenotype J:113489
increased granulocyte number J:113489
increased leukocyte cell number J:113489
small adrenal glands J:113489
small liver J:113489
Cxcr2tm1a(EUCOMM)Wtsi/Cxcr2+
C57BL/6N-Cxcr2tm1a(EUCOMM)Wtsi/Wtsi 		increased circulating creatinine level J:211773
increased circulating magnesium level J:211773
Cxcr2tm1a(EUCOMM)Wtsi/Cxcr2tm1a(EUCOMM)Wtsi
C57BL/6N-Cxcr2tm1a(EUCOMM)Wtsi/Wtsi 		decreased B cell number J:211773
decreased CD8-positive, alpha-beta T cell number J:211773
decreased circulating fructosamine level J:211773
decreased circulating serum albumin level J:211773
decreased circulating thyroxine level J:211773
decreased immature B cell number J:211773
decreased mature B cell number J:211773
decreased mean corpuscular hemoglobin J:211773
decreased pre-B cell number J:211773
decreased pre-pro B cell number J:211773
decreased T cell number J:211773
improved glucose tolerance J:211773
increased anti-nuclear antigen antibody level J:211773
increased CD4-positive, alpha-beta memory T cell number J:211773
increased CD8-positive, alpha-beta memory T cell number J:211773
increased CD103-positive CD11b-low dendritic cell number J:211773
increased circulating calcium level J:211773
increased circulating total protein level J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased effector memory T-helper cell number J:211773
increased eosinophil cell number J:211773
increased gamma-delta T cell number J:211773
increased granulocyte number J:211773
increased KLRG1+ CD4 alpha-beta T cell number J:211773
increased KLRG1+ CD8 alpha-beta T cell number J:211773
increased leukocyte cell number J:211773
increased Ly6C high monocyte number J:211773
increased Ly6C low monocyte number J:211773
increased memory-marker CD4-positive NK T cell number J:211773
increased memory-marker gamma-delta T cell number J:211773
increased memory-marker NK cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
thrombocytosis J:211773
Cxcr2tm1Mwm/Cxcr2+
C.129S2(B6)-Cxcr2tm1Mwm/J 		delayed wound healing J:63935
impaired neutrophil recruitment J:63935
Cxcr2tm1Mwm/Cxcr2tm1Mwm
B6.Cg-Il8rbtm1Mwm 		abnormal tumor morphology J:88233
decreased metastatic potential J:88233
decreased tumor growth/size J:88233
Cxcr2tm1Mwm/Cxcr2tm1Mwm
C.129S2(B6)-Cxcr2tm1Mwm/J 		abnormal airway responsiveness J:73947
abnormal chemokine level J:73947
abnormal cytokine secretion J:72824
abnormal eosinophil physiology J:73947
abnormal interleukin level J:73947, J:87365
abnormal leukocyte physiology J:94170
abnormal myelination J:78470
abnormal neutrophil physiology J:73947, J:93946
abnormal NK T cell physiology J:66399
abnormal respiratory mucosa goblet cell morphology J:82293
abnormal spinal cord morphology J:78470
abnormal T cell physiology J:73947
abnormal T-helper 1 physiology J:73947
abnormal T-helper 2 physiology J:73947
cornea vascularization J:87365
decreased airway responsiveness J:82293
decreased oligodendrocyte progenitor number J:78470
decreased susceptibility to fungal infection J:73947
decreased susceptibility to induced arthritis J:142880
decreased susceptibility to induced morbidity/mortality J:85647
delayed wound healing J:63935
impaired neutrophil chemotaxis J:65905, J:72824
impaired neutrophil recruitment J:63935, J:65425, J:93116
increased IgE level J:73947
increased susceptibility to bacterial infection J:65905
increased susceptibility to Herpesvirales infection J:87365
increased susceptibility to parasitic infection J:72824
Cxcr2tm1Mwm/Cxcr2tm1Mwm
involves: 129S2/SvPas 		decreased susceptibility to bacterial infection induced morbidity/mortality J:208901
Cxcr2tm1Mwm/Cxcr2tm1Mwm
involves: 129S2/SvPas * BALB/c 		abnormal myelopoiesis J:113489
abnormal neutrophil physiology J:113489
decreased body size J:113489
decreased thymus weight J:113489
extramedullary hematopoiesis J:113489
increased epididymis weight J:113489
increased granulocyte number J:113489
increased kidney weight J:113489
increased seminal vesicle weight J:113489
increased spleen weight J:113489
Cxcr2tm1Mwm/Cxcr2tm1Mwm
involves: 129S2/SvPas * C57BL/6J 		abnormal bone marrow morphology J:19570
abnormal granulocyte differentiation J:19570
abnormal myelopoiesis J:19570
abnormal spleen white pulp morphology J:19570
enlarged cervical lymph nodes J:19570
enlarged lymph nodes J:19570
enlarged spleen J:19570
normal hematopoietic system phenotype J:19570
impaired neutrophil chemotaxis J:19570
increased B cell number J:19570
increased circulating interleukin-6 level J:19570
increased neutrophil cell number J:19570
lymph node medullary cord hyperplasia J:19570
myeloid hyperplasia J:19570
Cxcr2tm1Rmra/Cxcr2tm1Rmra
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA 		abnormal neutrophil physiology J:204482
weight loss J:204482
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory