Il6ra Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il6ra
interleukin 6 receptor, alpha
MGI:105304

37 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il6ra^{em1(IMPC)Wtsi}/Il6ra^{em1(IMPC)Wtsi} C57BL/6N-Il6ra^{em1(IMPC)Wtsi}/Wtsi	increased red blood cell distribution width	J:211773
Il6ra^{tm1.1(IL6R)Csk}/Il6ra^{tm1.1(IL6R)Csk} involves: 129S6/SvEvTac * C57BL/6	abnormal circulating serum amyloid protein level	J:207264
Il6ra^{tm1.1(KOMP)Vlcg}/Il6ra^{tm1.1(KOMP)Vlcg} C57BL/6N-Il6ra^{tm1.1(KOMP)Vlcg}/Ucd	hydrometra	J:211773
Il6ra^tm1.1Drew/Il6ra^tm1.1Drew involves: C57BL/6 * C57BL/6N * SJL	no abnormal phenotype detected	J:160966
Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: C57BL/6 * C57BL/6N * SJL	normal immune system phenotype	J:160966
Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6N * SJL	decreased acute inflammation	J:160966
	normal homeostasis/metabolism phenotype	J:160966
Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Tg(GFAP-cre)8Gtm/0 involves: C57BL/6 * C57BL/6N * CBA	abnormal emotion/affect behavior	J:211914
	abnormal head movements	J:211914
	normal behavior/neurological phenotype	J:211914
	normal nervous system phenotype	J:211914
	preweaning lethality, incomplete penetrance	J:211914
Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * C57BL/6	decreased circulating interleukin-1 beta level	J:188445
	decreased circulating tumor necrosis factor level	J:188445
	decreased susceptibility to parasitic infection	J:188445
Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr Tg(Alb1-cre)7Gsc/0 involves: C57BL/6 * FVB/N	abnormal glycogen homeostasis	J:166367
	normal adipose tissue phenotype	J:166367
	normal behavior/neurological phenotype	J:166367
	decreased adipocyte glucose uptake	J:166367
	decreased circulating interleukin-1 beta level	J:188445
	decreased circulating tumor necrosis factor level	J:188445
	decreased insulin secretion	J:166367
	decreased liver glycogen level	J:166367
	decreased susceptibility to parasitic infection	J:188445
	normal growth/size/body region phenotype	J:166367
	normal homeostasis/metabolism phenotype	J:166367
	impaired glucose tolerance	J:166367
	increased circulating interleukin-6 level	J:166367
	increased circulating tumor necrosis factor level	J:166367
	increased glycogen catabolism rate	J:166367
	increased insulin secretion	J:166367
	insulin resistance	J:166367
Il6ra^tm1.2Drew/Il6ra^tm1.2Drew involves: C57BL/6 * C57BL/6N * FVB/N * SJL	abnormal inflammatory response	J:160966
	abnormal wound healing	J:160966
Il6ra^tm1.2Jcbr/Il6ra^tm1.2Jcbr involves: C57BL/6	decreased circulating interleukin-1 beta level	J:188445
	decreased circulating tumor necrosis factor level	J:188445
	decreased hepatocyte proliferation	J:202764
	decreased incidence of tumors by chemical induction	J:202764
	decreased susceptibility to parasitic infection	J:188445
	decreased susceptibility to parasitic infection induced morbidity/mortality	J:188445
	decreased tumor growth/size	J:202764
	normal growth/size/body region phenotype	J:202764
	increased circulating aspartate transaminase level	J:202764
	increased hepatocyte apoptosis	J:202764
	liver inflammation	J:202764
Il6ra^tm1Saj/Il6ra^tm1Saj involves: 129P2/OlaHsd * C57BL/6J	abnormal CD4-positive, alpha-beta T cell physiology	J:159479

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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