Il4ra Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il4ra
interleukin 4 receptor, alpha
MGI:105367

45 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il4ra^M1Btlr/Il4ra^M1Btlr C57BL/6J-Il4ra^M1Btlr	decreased IgE level	J:267558
Il4ra^M2Btlr/Il4ra^M2Btlr C57BL/6J-Il4ra^M2Btlr	decreased IgE level	J:272804
Il4ra^tm1Fbb/Il4ra^tm1Fbb involves: BALB/c	abnormal susceptibility to infection	J:55526
Il4ra^tm1Fbb/Il4ra^tm1Fbb involves: BALB/cJ	abnormal circulating cytokine level	J:133518
	abnormal circulating interferon-gamma level	J:133518
	abnormal crypts of Lieberkuhn morphology	J:133518
	abnormal cytokine secretion	J:114751
	abnormal immune system physiology	J:114751
	abnormal intestinal epithelium morphology	J:133518
	abnormal macrophage physiology	J:114751
	decreased T-helper 2 cell number	J:172134
	granulomatous inflammation	J:114751
	impaired macrophage chemotaxis	J:114751
	increased circulating interleukin-4 level	J:133518
	increased susceptibility to infection	J:114751
	increased susceptibility to parasitic infection	J:114751
	increased transforming growth factor beta level	J:133518
	liver inflammation	J:114751
	premature death	J:114751
	weight loss	J:114751
Il4ra^tm1Fbb/Il4ra^tm2Fbb Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * BALB/c	abnormal immune system physiology	J:114751
	abnormal intestinal goblet cell morphology	J:114751
	abnormal macrophage physiology	J:114751
	decreased susceptibility to parasitic infection	J:114751
	granulomatous inflammation	J:114751
	increased susceptibility to parasitic infection	J:114751
	liver fibrosis	J:114751
	liver inflammation	J:114751
	premature death	J:114751
	weight loss	J:114751
Il4ra^tm1Sz/Il4ra^tm1Sz BALB/c-Il4ra^tm1Sz	increased IgG2a level	J:110429
Il4ra^tm1Sz/Il4ra^tm1Sz BALB/c-Il4ra^tm1Sz	increased susceptibility to parasitic infection	J:110429
Il4ra^tm1Sz/Il4ra^tm1Sz BALB/c-Il4ra^tm1Sz/J	abnormal microglial cell morphology	J:125605
	abnormal susceptibility to infection	J:131994
	abnormal T-helper 2 physiology	J:43656
	decreased IgE level	J:43656
	decreased IgG1 level	J:43656
	decreased interleukin-4 secretion	J:43656
	decreased interleukin-5 secretion	J:43656
	decreased interleukin-10 secretion	J:43656
	increased IgG2a level	J:43656
Il4ra^tm1Tch/Il4ra^tm1Tch involves: 129X1/SvJ * BALB/c	abnormal immune serum protein physiology	J:86215
	abnormal T-helper 2 cell morphology	J:86215
	decreased T cell proliferation	J:86215
	increased airway responsiveness	J:86215
	increased IgE level	J:86215
	increased IgG level	J:86215
	respiratory system inflammation	J:86215
Il4ra^tm2Fbb/Il4ra^tm2Fbb Lyz2^tm1(cre)Ifo/? involves: 129P2/OlaHsd * BALB/c	decreased core body temperature	J:178294
	decreased fatty acids level	J:178294
Il4ra^tm2Tch/Il4ra^tm2Tch C.129X1-Il4ra^tm2Tch	abnormal bronchus morphology	J:152376
	abnormal T-helper 2 physiology	J:152376
	increased airway responsiveness	J:152376
	increased circulating interleukin-4 level	J:152376
	increased eosinophil cell number	J:152376
	increased IgE level	J:152376
	increased monocyte cell number	J:152376
	increased respiratory mucosa goblet cell number	J:152376
	increased susceptibility to type I hypersensitivity reaction	J:152376
	respiratory system inflammation	J:152376
Il4ra^tm3.1Tch/Il4ra^tm3.1Tch C.129X1-Il4ra^tm3.1Tch	abnormal macrophage activation involved in immune response	J:160806
	increased IgE level	J:160806
	increased interleukin-4 secretion	J:160806
	increased susceptibility to type I hypersensitivity reaction	J:160806

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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