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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
MGI:105368
85 phenotypes from 14 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atp2b2Deaf11/Atp2b2+
BALB/c-Atp2b2Deaf11 		decreased startle reflex J:199859
impaired hearing J:199859
increased or absent threshold for auditory brainstem response J:199859
Atp2b2Deaf11/Atp2b2Deaf11
BALB/c-Atp2b2Deaf11 		cochlear hair cell degeneration J:199859
decreased startle reflex J:199859
impaired hearing J:199859
increased or absent threshold for auditory brainstem response J:199859
Atp2b2Deaf11/Atp2b2Deaf13
BALB/c-Atp2b2Deaf11/Atp2b2Deaf13 		impaired hearing J:199859
increased or absent threshold for auditory brainstem response J:199859
Atp2b2Deaf13/Atp2b2+
BALB/c-Atp2b2Deaf13 		decreased startle reflex J:199859
impaired hearing J:199859
increased or absent threshold for auditory brainstem response J:199859
Atp2b2Deaf13/Atp2b2Deaf13
BALB/c-Atp2b2Deaf13 		cochlear hair cell degeneration J:199859
decreased startle reflex J:199859
impaired hearing J:199859
increased or absent threshold for auditory brainstem response J:199859
Atp2b2dfw-2J/Atp2b2+
CBA.Cg-Atp2b2dfw-2J 		normal behavior/neurological phenotype J:220660
Atp2b2dfw-2J/Atp2b2+
CByJ.A-Atp2b2dfw-2J/J 		deafness J:38429
increased or absent threshold for auditory brainstem response J:38429
increased susceptibility to age-related hearing loss J:38429
reduced linear vestibular evoked potential J:116914
Atp2b2dfw-2J/Atp2b2+
involves: CAST/Ei * BALB/cByJ 		normal hearing/vestibular/ear phenotype J:38429, J:70964
Atp2b2dfw-2J/Atp2b2dfw-2J
CBA.Cg-Atp2b2dfw-2J 		impaired swimming J:220660
Atp2b2dfw-2J/Atp2b2dfw-2J
CByJ.A-Atp2b2dfw-2J/J 		abnormal gait J:38429
abnormal reflex J:116914
absent linear vestibular evoked potential J:116914
ataxia J:38429
deafness J:38429
head bobbing J:38429
impaired swimming J:116914
increased or absent threshold for auditory brainstem response J:38429
infertility J:38429
lethargy J:38429
tremors J:38429
Atp2b2dfw-3J/Atp2b2dfw-3J
involves: C57BL/6J * C57BLKS/J 		abnormal auditory brainstem response J:77607
abnormal motor coordination/balance J:77607
deafness J:77607
tremors J:77607
Atp2b2dfw-i5/Atp2b2+
involves: C57BL/6J * CBA/CaJ * DBA/2J 		abnormal cochlear hair cell stereociliary bundle morphology J:220660
normal behavior/neurological phenotype J:220660
Atp2b2dfw-i5/Atp2b2dfw-i5
involves: C57BL/6J * CBA/CaJ * DBA/2J 		abnormal cochlear hair cell stereociliary bundle morphology J:220660
abnormal hearing physiology J:220660
abnormal motor coordination/balance J:220660
circling J:220660
deafness J:220660
decreased threshold for auditory brainstem response J:220660
head tossing J:220660
impaired balance J:220660
impaired coordination J:220660
stereotypic behavior J:220660
Atp2b2dfw/Atp2b2+
C3H/HeJ-Atp2b2dfw/J 		abnormal auditory brainstem response waveform shape J:108888
abnormal cochlear microphonics J:108888
abnormal cochlear nerve compound action potential J:108888
abnormal distortion product otoacoustic emission J:108888
decreased distortion product otoacoustic emission amplitude J:108888
increased or absent distortion product otoacoustic emission threshold J:108888
increased or absent threshold for auditory brainstem response J:108888
Atp2b2dfw/Atp2b2+
CBA.C3-Atp2b2dfw 		normal behavior/neurological phenotype J:220660
Atp2b2dfw/Atp2b2dfw
C3H/HeJ-Atp2b2dfw/J 		abnormal calcium ion homeostasis J:119503
abnormal cochlear ganglion morphology J:121326
abnormal cochlear hair cell physiology J:119503
abnormal cochlear VIII nucleus morphology J:121326
abnormal gait J:14114
abnormal hair cell mechanoelectric transduction J:119503
abnormal vestibular hair cell physiology J:119503
absent distortion product otoacoustic emissions J:108888
absent outer hair cell stereocilia J:121326
cochlear ganglion degeneration J:121326
cochlear hair cell degeneration J:121326
cochlear outer hair cell degeneration J:121326
deafness J:14114, J:108888
head bobbing J:14114
increased or absent threshold for auditory brainstem response J:108888
Atp2b2Elfin/Atp2b2+
involves: C3H/HeJ * C57BL/6J 		abnormal outer hair cell stereociliary bundle morphology J:196569
cochlear ganglion degeneration J:196569
cochlear outer hair cell degeneration J:196569
impaired hearing J:196569
increased or absent threshold for auditory brainstem response J:196569
organ of Corti degeneration J:196569
Atp2b2Elfin/Atp2b2Elfin
involves: C3H/HeJ * C57BL/6J 		abnormal inner ear vestibule morphology J:196569
abnormal vestibular saccule morphology J:196569
absent vestibular hair cells J:196569
ataxia J:196569
decreased body weight J:196569
impaired balance J:196569
increased or absent threshold for auditory brainstem response J:196569
limb grasping J:196569
organ of Corti degeneration J:196569
Atp2b2jog/Atp2b2jog
involves: C57BL/6 * DSO 		abnormal cell death J:111625
abnormal posture J:111625
ataxia J:111625
decreased body weight J:111625
impaired limb coordination J:111625
limb grasping J:111625
small cerebellum J:111625
tremors J:111625
Atp2b2m1Btlr/Atp2b2m1Btlr
C57BL/6J-Atp2b2m1Btlr 		ataxia J:221473
head bobbing J:221473
limb grasping J:221473
tremors J:221473
Atp2b2m2Btlr/Atp2b2m2Btlr
C57BL/6J-Atp2b2m2Btlr 		decreased body weight J:271981
Atp2b2Obv/Atp2b2+
C3HeB/FeJ-Atp2b2Obv 		abnormal vestibular hair cell physiology J:151733
absent pinna reflex J:151733
cochlear hair cell degeneration J:151733
cochlear inner hair cell degeneration J:151733
cochlear outer hair cell degeneration J:151733
deafness J:151733
impaired hearing J:151733
increased or absent threshold for auditory brainstem response J:151733
Atp2b2Obv/Atp2b2Obv
C3HeB/FeJ-Atp2b2Obv 		abnormal reflex J:151733
abnormal vestibular hair cell physiology J:151733
abnormal vestibular system physiology J:151733
absent pinna reflex J:151733
ataxia J:151733
circling J:151733
cochlear hair cell degeneration J:151733
deafness J:151733
decreased body size J:151733
decreased body weight J:151733
head tossing J:151733
impaired balance J:151733
impaired righting response J:151733
organ of Corti degeneration J:151733
pillar cell degeneration J:151733
Atp2b2tm1Ges/Atp2b2+
involves: 129/Sv * 129X1/SvJ * Black Swiss 		abnormal organ of Corti morphology J:48863
impaired hearing J:48863
increased or absent threshold for auditory brainstem response J:48863
Atp2b2tm1Ges/Atp2b2+
involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ 		increased or absent threshold for auditory brainstem response J:108881
increased susceptibility to age-related hearing loss J:108881
Atp2b2tm1Ges/Atp2b2+
involves: 129/Sv * 129X1/SvJ * Black Swiss * CAST/Ei 		increased susceptibility to noise-induced hearing loss J:108881
Atp2b2tm1Ges/Atp2b2tm1Ges
involves: 129/Sv * 129X1/SvJ * Black Swiss 		abnormal auditory brainstem response J:108937
abnormal auditory cortex morphology J:108937
abnormal calcium ion homeostasis J:108937, J:119503
abnormal cerebellar granule cell morphology J:48863
abnormal cerebellum morphology J:48863
abnormal cerebral cortex morphology J:108937
abnormal cochlear hair cell physiology J:119503
abnormal cochlear nerve morphology J:48863
abnormal gait J:48863
abnormal hair cell mechanoelectric transduction J:119503
abnormal inner ear morphology J:48863
abnormal inner ear vestibule morphology J:48863
abnormal organ of Corti morphology J:48863
abnormal reflex J:48863
abnormal vestibular hair cell physiology J:119503
absent cochlear hair cells J:48863
absent distortion product otoacoustic emissions J:108937
absent organ of Corti supporting cells J:48863
absent otoliths J:48863
absent pillar cells J:48863
absent tunnel of Corti J:48863
ataxia J:48863
deafness J:48863, J:108937
decreased body weight J:48863
decreased cochlear hair cell number J:48863
decreased organ of Corti supporting cell number J:48863
impaired balance J:48863
impaired righting response J:48863
increased or absent threshold for auditory brainstem response J:48863
increased Purkinje cell number J:48863
sensorineural hearing loss J:48863
thin cerebellar molecular layer J:48863
Atp2b2Tmy/Atp2b2+
involves: BALB/c * C3H/HeH 		deafness J:167344
normal hearing/vestibular/ear phenotype J:167344
increased or absent threshold for auditory brainstem response J:167344
increased susceptibility to age-related hearing loss J:169366
syndromic hearing loss J:169366
Atp2b2Tmy/Atp2b2Tmy
involves: BALB/c * C3H/HeH 		abnormal gait J:167344
ataxia J:167344
deafness J:167344
decreased body size J:167344
increased or absent threshold for auditory brainstem response J:167344
Atp2b2wri/Atp2b2+
involves: BALB/cAnN 		cochlear degeneration J:56737, J:71283
cochlear ganglion degeneration J:71283
deafness J:56737
Atp2b2wri/Atp2b2wri
involves: BALB/cAnN 		abnormal gait J:1273
abnormal motor coordination/balance J:1273
abnormal postural reflex J:1273
abnormal Purkinje cell differentiation J:13355
abnormal Purkinje cell innervation J:13355
abnormal vestibular saccule morphology J:71283
cochlear degeneration J:56737
cochlear ganglion degeneration J:71283
cochlear outer hair cell degeneration J:71283
deafness J:56737, J:71283
increased or absent threshold for auditory brainstem response J:71283
tremors J:1273
vestibular saccular degeneration J:56737
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11/05/2024
MGI 6.24 		The Jackson Laboratory