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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptch1
patched 1
MGI:105373
153 phenotypes from 15 alleles in 29 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptch1dl/Ptch1dl
involves: 129S1/SvImJ * C57BL/6J 		abnormal basicranium morphology J:204468
abnormal basisphenoid bone morphology J:204468
abnormal cranium morphology J:204468
abnormal frontal bone morphology J:204468
abnormal head morphology J:204468
abnormal interparietal bone morphology J:204468
abnormal intramembranous bone ossification J:204468
abnormal lambdoid suture morphology J:204468
abnormal parietal bone morphology J:204468
abnormal sternum manubrium morphology J:204468
abnormal sternum morphology J:204468
abnormal xiphoid process morphology J:204468
absent palatal shelf J:204468
absent presphenoid bone J:204468
alisphenoid bone hypoplasia J:204468
asymmetric sternocostal joints J:204468
cleft secondary palate J:204468
domed cranium J:204468
increased body size J:204468
palatal shelf hypoplasia J:204468
postnatal lethality, complete penetrance J:204468
preaxial polydactyly J:204468
scapular bone foramen J:204468
short mandibular coronoid process J:204468
small basisphenoid bone J:204468
Ptch1dl/Ptch1tm1Mps
involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J 		abnormal craniofacial morphology J:204468
abnormal interparietal bone morphology J:204468
abnormal lambdoid suture morphology J:204468
abnormal neurocranium morphology J:204468
abnormal parietal bone morphology J:204468
abnormal sternum morphology J:204468
absent presphenoid bone J:204468
alisphenoid bone hypoplasia J:204468
exencephaly J:204468
kinked tail J:204468
lethality throughout fetal growth and development, incomplete penetrance J:204468
mandibular coronoid process hypoplasia J:204468
palatal shelf hypoplasia J:204468
preaxial polydactyly J:204468
scapular bone foramen J:204468
small basisphenoid bone J:204468
syndactyly J:204468
Ptch1dl/Ptch1tm1Zim
involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J 		abnormal head morphology J:204468
domed cranium J:204468
increased fetal size J:204468
kinked tail J:204468
omphalocele J:204468
Ptch1mes/Ptch1mes
B6C3Fe a/a-Ptch1mes 		abnormal foot pad morphology J:32739
abnormal skeleton morphology J:23861
abnormal spermatogenesis J:32739
abnormal tendon morphology J:23861
abnormal thoracic cavity morphology J:32739
belly spot J:23861
cryptorchism J:23861
decreased fear-related response J:32739
dermal hyperplasia J:23861, J:32739
female infertility J:23861
kinked tail J:23861
kyphosis J:32739
male infertility J:23861
ocular hypertelorism J:23861
polydactyly J:23861
short tail J:23861
shortened head J:23861
small male preputial gland J:32739
small seminal vesicle J:32739
thick tail J:32739
Ptch1mes/Ptch1mes
involves: CBA/J 		abnormal enamel morphology J:156471
abnormal upper incisor morphology J:156471
Ptch1tm1.1Bjw/Ptch1tm1.1Bjw
involves: 129T2/SvEms * C57BL/6J 		abnormal craniofacial morphology J:85040
abnormal telencephalon development J:85040
absent forebrain J:85040
embryonic growth arrest J:85040
open neural tube J:85040
prenatal lethality J:85040
Ptch1tm1.1Hahn/Ptch1+
involves: 129 * BALB/c * C57BL/6 * FVB/N 		increased medulloblastoma incidence J:149148
increased rhabdomyosarcoma incidence J:149148
increased tumor incidence J:149148
premature death J:149148
Ptch1tm1.1Hahn/Ptch1tm1.1Hahn
involves: 129 * BALB/c * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:149148
open neural tube J:149148
Ptch1tm1Bjw/Ptch1tm1Bjw
involves: 129T2/SvEms 		increased neuronal precursor cell number J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw
involves: 129T2/SvEms * C57BL/6J 		no abnormal phenotype detected J:85040
Ptch1tm1Bjw/Ptch1tm1Bjw
Tcf21tm1(cre)Seq/Tcf21+
involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ 		abnormal kidney collecting duct morphology J:189643
abnormal kidney morphology J:189643
abnormal kidney pelvis morphology J:189643
increased tumor incidence J:189643
kidney cyst J:189643
prenatal lethality J:189643
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre)1Bfri/0
involves: 129T2/SvEms * C57BL/6 * CBA 		abnormal cerebellum external granule cell layer morphology J:139573
abnormal cerebellum morphology J:139573
abnormal neuronal precursor proliferation J:139573
enlarged cerebellum J:139573
increased medulloblastoma incidence J:139573
increased neuronal precursor cell number J:189258
normal nervous system phenotype J:189258
premature death J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129T2/SvEms * FVB/N 		abnormal cerebellum external granule cell layer morphology J:139573
abnormal neuronal precursor proliferation J:139573
enlarged cerebellum J:139573
increased medulloblastoma incidence J:139573
premature death J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(GFAP-cre)25Mes/0
involves: 129T2/SvEms * FVB/N 		abnormal cerebellum external granule cell layer morphology J:139573
abnormal rhombic lip morphology J:139573
increased medulloblastoma incidence J:139573
increased neuronal precursor cell number J:139573
premature death J:139573
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(KRT14-cre)8Brn/0
involves: 129T2/SvEms * FVB/N 		decreased circulating insulin-like growth factor I level J:231264
increased basal cell carcinoma incidence J:231264
infertility J:231264
postnatal growth retardation J:231264
skin lesions J:231264
thymus hypoplasia J:231264
Ptch1tm1Cklr/Ptch1+
Pax7tm1(cre)Mrc/Pax7+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		ataxia J:159972
increased medulloblastoma incidence J:159972
Ptch1tm1Cklr/Ptch1tm1Cklr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal neoplasm J:159972
Ptch1tm1Hahn/Ptch1+
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		premature death J:149148
Ptch1tm1Hahn/Ptch1+
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		epidermal cyst J:149148
increased fibroma incidence J:149148
increased tumor incidence J:149148
premature death J:149148
Ptch1tm1Hahn/Ptch1tm1Hahn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:127207
Ptch1tm1Hahn/Ptch1tm1Hahn
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased tumor growth/size J:158915
increased basal cell carcinoma incidence J:158915
Ptch1tm1Hahn/Ptch1tm1Hahn
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		increased basal cell carcinoma incidence J:149148
increased tumor incidence J:149148
premature death J:149148
Ptch1tm1Hahn/Ptch1tm1Hahn
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal double-negative T cell morphology J:127207
abnormal hematopoietic system morphology/development J:127207
abnormal thymus lobule morphology J:127207
decreased B cell number J:127207
decreased double-positive T cell number J:127207
decreased immature B cell number J:127207
decreased lymphocyte cell number J:127207
decreased pre-B cell number J:127207
decreased transitional stage B cell number J:127207
increased B cell number J:127207
increased basal cell carcinoma incidence J:149148
increased double-negative T cell number J:127207
increased mature B cell number J:127207
increased neutrophil cell number J:127207
increased single-positive T cell number J:127207
increased tumor incidence J:149148
premature death J:149148
thymus hypoplasia J:127207
Ptch1tm1Kmmt/Ptch1+
involves: 129S7/SvEvBrd * C57BL/6J 		mandibular cyst J:102978
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ 		focal hair loss J:82653
increased medulloblastoma incidence J:102702, J:114992, J:144811
increased rhabdomyosarcoma incidence J:114992
increased skin tumor incidence J:82653
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
decreased tumor-free survival time J:205254
increased gastrointestinal tumor incidence J:205254
increased hemangiosarcoma incidence J:205254
increased lymphoma incidence J:205254
increased medulloblastoma incidence J:205254
increased rhabdomyosarcoma incidence J:205254
increased tumor incidence J:205254
premature death J:112118
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		increased body size J:42441
increased medulloblastoma incidence J:42441
increased tumor incidence J:42441
polydactyly J:42441
syndactyly J:42441
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J 		increased basal cell carcinoma incidence J:58328
increased incidence of tumors by ionizing radiation induction J:58328
increased incidence of tumors by UV-induction J:58328
Ptch1tm1Mps/Ptch1+
Tg(Atoh1-GFP)1Jejo/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		increased medulloblastoma incidence J:144811
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ 		craniorachischisis J:297055
embryonic lethality prior to organogenesis J:297055
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal heart development J:42441
embryonic lethality, complete penetrance J:42441
open neural tube J:42441
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		embryonic lethality during organogenesis, complete penetrance J:79392
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		abnormal diencephalon morphology J:94269
abnormal neural tube morphology J:94269
abnormal neuronal precursor cell number J:94269
Ptch1tm1Yy/Ptch1+
Tg(BGLAP-cre)1Clem/0
involves: 129 * C57BL/6 * FVB/NJ 		normal mortality/aging J:214349
normal neoplasm J:214349
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * SJL 		abnormal bone mineralization J:112462
abnormal bone ossification J:112462
abnormal cranium morphology J:112462
abnormal long bone hypertrophic chondrocyte zone J:112462
abnormal osteoblast differentiation J:112462
decreased length of long bones J:112462
fused synovial joints J:112462
increased chondrocyte proliferation J:112462
Ptch1tm1Yy/Ptch1tm1Yy
Not Specified 		prenatal lethality, incomplete penetrance J:112462
Ptch1tm1Yy/Ptch1tm1Yy
Tg(BGLAP-cre)1Clem/0
involves: 129 * C57BL/6 * FVB/NJ 		abnormal bone ossification J:214349
premature death J:214349
Ptch1tm1Zim/Ptch1+
either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) 		abnormal rib morphology J:47421
decreased rib number J:47421
dermal cyst J:47421
exencephaly J:47421
incomplete rostral neuropore closure J:47421
increased body size J:47421
increased fetal size J:47421
increased incidence of tumors by ionizing radiation induction J:47421
increased medulloblastoma incidence J:47421
increased rhabdomyosarcoma incidence J:47421
lethality throughout fetal growth and development, incomplete penetrance J:47421
mandibular cyst J:47421
polydactyly J:47421
preaxial polydactyly J:47421
Ptch1tm1Zim/Ptch1+
involves: 129 * CD-1 		increased incidence of tumors by ionizing radiation induction J:79666, J:165388
increased medulloblastoma incidence J:79666, J:165388
increased mortality induced by ionizing radiation J:79666
Ptch1tm1Zim/Ptch1tm1Zim
involves: 129 		abnormal neural tube closure J:47421
embryonic lethality during organogenesis, incomplete penetrance J:47421
Ptch1tm2Mps/Ptch1tm2Mps
involves: 129S1/Sv * 129X1/SvJ 		infertility J:82653
Ptch1wig/Ptch1wig
involves: 129S1/Sv * C57BL/6 * FVB/NJ 		abnormal cranial ganglia morphology J:171522
abnormal geniculate ganglion morphology J:171522
abnormal glossopharyngeal ganglion morphology J:171522
abnormal mandibular prominence morphology J:171522
abnormal maxillary prominence morphology J:171522
abnormal nasal placode morphology J:171522
abnormal nervous system morphology J:171522
abnormal neural plate morphology J:171522
abnormal neuron differentiation J:171522
abnormal trigeminal ganglion morphology J:171522
abnormal vascular development J:171522
abnormal vestibulocochlear ganglion morphology J:171522
absent fourth pharyngeal arch J:171522
absent optic vesicle J:171522
absent third pharyngeal arch J:171522
craniorachischisis J:171522
embryonic lethality during organogenesis, complete penetrance J:171522
exencephaly J:171522
increased embryo size J:171522
open neural tube J:171522
small otic vesicle J:171522
small second pharyngeal arch J:171522
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11/12/2024
MGI 6.24 		The Jackson Laboratory