Ptch1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptch1
patched 1
MGI:105373

68 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Brca2^tm1Brn/Brca2^tm1Brn Ptch1^tm1Mps/Ptch1⁺ Trp53^tm1Tyj/Trp53⁺ Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	increased medulloblastoma incidence	J:144617
Brca2^tm1Brn/Brca2^tm1Brn Ptch1^tm1Mps/Ptch1⁺ Trp53^tm1Tyj/Trp53^tm1Tyj Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	increased medulloblastoma incidence	J:144617
Cdkn1b^tm1Mlf/Cdkn1b⁺ Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	abnormal cerebellar molecular layer	J:205254
	hydrocephaly	J:205254
	increased gastrointestinal tumor incidence	J:205254
	increased hemangiosarcoma incidence	J:205254
	increased lymphoma incidence	J:205254
	increased medulloblastoma incidence	J:205254
	increased rhabdomyosarcoma incidence	J:205254
	increased tumor incidence	J:205254
	premature death	J:205254
Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	abnormal cerebellar molecular layer	J:205254
	hydrocephaly	J:205254
	increased gastrointestinal tumor incidence	J:205254
	increased hemangiosarcoma incidence	J:205254
	increased lymphoma incidence	J:205254
	increased medulloblastoma incidence	J:205254
	increased rhabdomyosarcoma incidence	J:205254
	increased tumor incidence	J:205254
	premature death	J:205254
Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	abnormal neuron differentiation	J:102702
	increased medulloblastoma incidence	J:102702
Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cerebellar molecular layer	J:205254
	increased medulloblastoma incidence	J:205254
Chmp1a^Gt(XC472)Byg/Chmp1a^Gt(XC472)Byg Ptch1^tm1Mps/Ptch1⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	normal nervous system phenotype	J:271138
Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy Ptch1^tm1Yy/Ptch1^tm1.1Yy Tg(Col2a1-cre)1Bhr/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal elbow joint morphology	J:112462
	abnormal long bone hypertrophic chondrocyte zone	J:112462
	abnormal perichondrium morphology	J:112462
	arrested osteoblast differentiation	J:112462
	normal craniofacial phenotype	J:112462
	decreased bone mineralization	J:112462
	delayed endochondral bone ossification	J:112462
	fused synovial joints	J:112462
Disp1^icb/Disp1^icb Ptch1^tm1Mps/Ptch1^tm1Mps involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	abnormal head morphology	J:79027
	abnormal neural tube morphology	J:79027
	embryonic lethality, complete penetrance	J:79027
	open neural tube	J:79027
Disp1^tm1Amc/Disp1^tm1Amc Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129X1/SvJ	normal nervous system phenotype	J:92058
	no abnormal phenotype detected	J:92058
Dync2h1^lln/Dync2h1^lln Ptch1^tm1Mps/Ptch1^tm1Mps involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:100466
Gli1^tm1Alj/Gli1^tm1Alj Ptch1^tm1Mps/Ptch1^tm1Mps involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster	embryonic lethality during organogenesis, complete penetrance	J:79392
Gli2^tm1Alj/Gli2^tm1Alj Ptch1^tm1Mps/Ptch1^tm1Mps involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	abnormal brain development	J:79392
	abnormal spinal cord morphology	J:79392
	abnormal ventral interneuron 3 morphology	J:79392
	embryonic lethality during organogenesis, complete penetrance	J:79392
	exencephaly	J:79392
	increased motor neuron number	J:79392
	normal nervous system phenotype	J:79392
Gli2^tm3.1Blnw/Gli2^tm3.1Blnw Ptch1^tm1Mps/? involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6	abnormal neural tube morphology	J:186503
Gpr37l1^tm1.2Gtva/Gpr37l1^tm1.2Gtva Ptch1^tm1Zim/Ptch1⁺ STOCK Gpr37l1^tm1.2Gtva Ptch1^tm1Zim/Cnrm	decreased cerebellar granule cell precursor proliferation	J:272049
	hydrocephaly	J:272049
	increased medulloblastoma incidence	J:272049
	increased tumor incidence	J:272049
	increased tumor latency	J:272049
Hhat^{Tg(TFAP2A-cre)1Will}/Hhat⁺ Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal craniofacial morphology	J:190013
Hhip^tm1Amc/Hhip⁺ Ptch1^tm1Mps/Ptch1^tm1Mps Tg(Mt1-Ptch1)MT22Mps/0 involves: 129S1/Sv * 129X1/SvJ * FVB	abnormal neural tube morphology	J:94269
	abnormal neuronal precursor cell number	J:94269
	exencephaly	J:94269
	small first pharyngeal arch	J:94269
	spina bifida	J:94269
Hhip^tm1Amc/Hhip^tm1Amc Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal branching involved in pancreas development	J:85472
	abnormal neural tube morphology	J:94269
	abnormal pancreas development	J:85472
	abnormal pulmonary alveolar duct morphology	J:94269
	abnormal stomach glandular epithelium morphology	J:85472
	embryonic lethality, complete penetrance	J:85472
	incomplete rostral neuropore closure	J:94269
	increased embryo size	J:94269
	increased neuronal precursor cell number	J:94269
	small lung	J:85472
Hhip^tm1Amc/Hhip^tm1Amc Ptch1^tm1Mps/Ptch1^tm1Mps Tg(Mt1-Ptch1)MT22Mps/0 involves: 129S1/Sv * 129X1/SvJ * FVB	abnormal neural tube morphology	J:94269
	abnormal neuronal precursor cell number	J:94269
	anophthalmia	J:94269
	embryonic lethality during organogenesis, incomplete penetrance	J:94269
	enlarged first pharyngeal arch	J:94269
	enlarged floor plate	J:94269
	incomplete rostral neuropore closure	J:94269
Ihh^tm1Amc/Ihh^tm1Amc Ptch1^tm1Mps/Ptch1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal palatal shelf bone ossification	J:182649
Kif7^maki/Kif7^maki Ptch1^tm1Mps/Ptch1^tm1Mps Tg(Hlxb9-GFP)1Tmj/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	abnormal neural tube morphology	J:151965
	embryonic lethality during organogenesis, complete penetrance	J:151965
Mtss1^tm1Pla/Mtss1^tm1Pla Ptch1^tm1Mps/Ptch1^tm1Mps involves: 129S1/Sv * 129X1/SvJ	embryonic lethality, complete penetrance	J:182970
Parms1^BALB/cByJ/Parms1^C57BL/6NCrl Ptch1^tm1Zim/Ptch1⁺ involves: 129/Sv * BALB/cByJ * C57BL/6NCrl	increased rhabdomyosarcoma incidence	J:93364
Parms1^C57BL/6NCrl/Parms1^C57BL/6NCrl Ptch1^tm1Zim/Ptch1⁺ involves: 129/Sv * BALB/cByJ * C57BL/6NCrl	increased rhabdomyosarcoma incidence	J:93364
Pgbd5^tm1.1Aken/Pgbd5^tm1.2Aken Ptch1^tm1Bjw/Ptch1^tm1Bjw Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW	increased medulloblastoma incidence	J:346387
Pgbd5^tm1.2Aken/Pgbd5^tm1.2Aken Ptch1^tm1Bjw/Ptch1^tm1Bjw Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW	decreased classified tumor incidence	J:346387
	increased tumor-free survival time	J:346387
Ptch1^tm1Cklr/Ptch1⁺ Trp53^tm1Brn/? Pax7^tm1(cre)Mrc/Pax7⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	increased medulloblastoma incidence	J:159972
Ptch1^tm1Mps/Ptch1⁺ Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129 * 129S2/SvPas * C57BL/6	increased medulloblastoma incidence	J:125534
	increased rhabdomyosarcoma incidence	J:125534
	premature death	J:125534
Ptch1^tm1Mps/Ptch1⁺ Ptch2^tm1Pmc/Ptch2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal intestine morphology	J:112118
	decreased tumor latency	J:112118
	increased basal cell carcinoma incidence	J:112118
	increased rhabdomyosarcoma incidence	J:112118
	increased testicular teratoma incidence	J:112118
	telangiectasia	J:112118
Ptch1^tm1Mps/Ptch1⁺ Ptch2^tm1Pmc/Ptch2⁺ Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	normal neoplasm	J:112118
Ptch1^tm1Mps/Ptch1⁺ Ptch2^tm1Pmc/Ptch2^tm1Pmc involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal intestine morphology	J:112118
	decreased tumor latency	J:112118
	increased basal cell carcinoma incidence	J:112118
	increased medulloblastoma incidence	J:112118
	increased rhabdomyosarcoma incidence	J:112118
	increased tumor incidence	J:112118
Ptch1^tm1Mps/Ptch1⁺ Tg(Shh)#Dje/0 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:108507
	abnormal cerebellum development	J:108507
	abnormal cerebellum morphology	J:108507
Ptch1^tm1Mps/Ptch1⁺ Shh^tm6Amc/Shh^tm6Amc involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:132152
Ptch1^tm1Mps/Ptch1⁺ Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR	increased medulloblastoma incidence	J:181542
Ptch1^tm1Mps/Ptch1^tm1Mps Tmem107^schlei/Tmem107^schlei involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	abnormal head morphology	J:186552
	abnormal neural tube closure	J:186552
	decreased embryo size	J:186552
	exencephaly	J:186552
Ptch1^tm1Mps/Ptch1^tm1Mps Wdpcp^cys40/Wdpcp^cys40 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal embryo development	J:205269
Ptch1^tm1Yy/Ptch1⁺ Trp53^tm1Brd/Trp53⁺ Tg(BGLAP-cre)1Clem/0 involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ	increased metastatic potential	J:214349
	increased osteosarcoma incidence	J:214349
	paralysis	J:214349
Ptch1^tm1Zim/Ptch1^tm1Zim Stil^tm1Mku/Stil^tm1Mku involves: 129 * C57BL/6 * CD-1	abnormal apoptosis	J:72500
	embryonic lethality during organogenesis, complete penetrance	J:72500
	holoprosencephaly	J:72500

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