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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lama5
laminin, alpha 5
MGI:105382
111 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lama5b2b2966.1Clo/Lama5b2b2966.1Clo
C57BL/6J-Lama5b2b2966.1Clo 		abnormal autopod morphology J:175213
abnormal pulmonary artery morphology J:175213
abnormal right subclavian artery morphology J:175213
abnormal thoracic cavity morphology J:175213
absent kidney J:175213
anophthalmia J:175213
atrioventricular septal defect J:175213
curly tail J:175213
decreased body size J:175213
dilated renal tubule J:175213
double outlet right ventricle J:175213
exencephaly J:175213
interrupted aortic arch J:175213
kidney cyst J:175213
left pulmonary isomerism J:175213
lowered ear position J:175213
mesocardia J:175213
microphthalmia J:175213
persistent truncus arteriosus J:175213
pulmonary artery hypoplasia J:175213
right aortic arch J:175213
syndactyly J:175213
thymus hypoplasia J:175213
vascular ring J:175213
ventricular septal defect J:175213
Lama5Gt1Jhm/Lama5+
Not Specified 		abnormal tooth development J:108325
Lama5Gt1Jhm/Lama5Gt1Jhm
Not Specified 		abnormal brain development J:108325
abnormal digit morphology J:108325
abnormal embryo size J:108325
abnormal extraembryonic tissue morphology J:108325
abnormal head morphology J:108325
abnormal limb morphology J:108325
abnormal lung morphology J:108325
abnormal nervous system morphology J:108325
lethality throughout fetal growth and development, complete penetrance J:108325
Lama5mpc205H/Lama5mpc205H
involves: BALB/c * C3H/HeH * C57BL/6J 		increased blood urea nitrogen level J:234901
increased circulating creatinine level J:234901
Lama5tm1.1Mggte/Lama5tm1.1Mggte
involves: 129P2/OlaHsd 		abnormal epidermal-dermal junction morphology J:286800
abnormal hair follicle dermal papilla morphology J:286800
abnormal hair follicle development J:286800
abnormal intestinal mucosa morphology J:286800
abnormal small intestinal villus morphology J:286800
clubbed small intestinal villi J:286800
decreased hair follicle number J:286800
Lama5tm1b(KOMP)Wtsi/Lama5+
C57BL/6N-Lama5tm1b(KOMP)Wtsi/H 		enlarged heart J:211773
Lama5tm1b(KOMP)Wtsi/Lama5tm1b(KOMP)Wtsi
C57BL/6N-Lama5tm1b(KOMP)Wtsi/H 		preweaning lethality, complete penetrance J:211773
Lama5tm1Jhm/Lama5+
involves: 129S1/Sv * 129X1/SvJ 		abnormal tooth development J:108325
Lama5tm1Jhm/Lama5tm1Jhm
involves: 129 * C57BL/6J 		abnormal glomerular capillary endothelium morphology J:59925
abnormal glomerular capillary morphology J:59925
abnormal intestinal epithelium morphology J:84903
abnormal intestinal goblet cell morphology J:84903
abnormal intestine morphology J:84903
abnormal kidney development J:59925
abnormal limb morphology J:51557
abnormal mesangial cell morphology J:59925
abnormal placenta morphology J:51557
abnormal placental labyrinth vasculature morphology J:51557
abnormal podocyte morphology J:59925
abnormal right lung morphology J:77264
abnormal trophoblast layer morphology J:51557
abnormal visceral pleura morphology J:77264
absent kidney J:59925
absent neurocranium J:51557
absent ureter J:59925
decreased fetal size J:51557
decreased placental labyrinth size J:51557
exencephaly J:51557
impaired basement membrane formation J:77264
impaired branching involved in ureteric bud morphogenesis J:84903
incomplete rostral neuropore closure J:51557
lethality throughout fetal growth and development, complete penetrance J:51557
megacephaly J:51557
small kidney J:59925
small lung J:77264
syndactyly J:51557
Lama5tm1Jhm/Lama5tm2Jhm
Tg(SFTPC-rtTA)5Jaw/?
Tg(tetO-cre)1Jaw/?
involves: 129S1/Sv * 129X1/SvJ 		abnormal lung development J:104565
abnormal lung vasculature morphology J:104565
abnormal pulmonary alveolus epithelium morphology J:104565
abnormal pulmonary alveolus morphology J:104565
absent type I pneumocytes J:104565
cyanosis J:104565
decreased cell proliferation J:104565
decreased type II pneumocyte number J:104565
increased apoptosis J:104565
neonatal lethality, complete penetrance J:104565
overexpanded pulmonary alveolus J:104565
pulmonary hypoplasia J:104565
respiratory distress J:104565
respiratory failure J:104565
thin lung-associated mesenchyme J:104565
Lama5tm1Lsor/Lama5tm1Lsor
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * SJL 		abnormal marginal zone B cell physiology J:198783
decreased marginal zone B cell number J:198783
decreased transitional stage T2 B cell number J:198783
increased B cell number J:198783
increased IgM level J:198783
increased transitional stage T1 B cell number J:198783
Lama5tm2Jhm/Lama5tm1Jhm
Tg(NPHS2-cre)295Lbh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL 		abnormal kidney morphology J:185850
abnormal renal glomerulus basement membrane morphology J:185850
decreased circulating serum albumin level J:185850
edema J:185850
expanded mesangial matrix J:185850
glomerulosclerosis J:185850
hematuria J:185850
increased circulating cholesterol level J:185850
increased renal glomerulus basement membrane thickness J:185850
increased urine protein level J:185850
podocyte foot process effacement J:185850
tubulointerstitial nephritis J:185850
Lama5tm2Jhm/Lama5tm2Jhm
Tg(ACTA1-cre)1Mll/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal neuromuscular synapse morphology J:142595
Lama5tm2Jhm/Lama5tm2Jhm
Tg(NPHS2-cre)295Lbh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL 		postnatal lethality, incomplete penetrance J:185850
Lama5tm3Jhm/Lama5tm3Jhm
involves: 129S1/Sv * 129X1/SvJ 		abnormal renal glomerulus basement membrane morphology J:128225
decreased body size J:128225
dilated renal tubule J:128225
enlarged kidney J:128225
increased blood urea nitrogen level J:128225
increased kidney apoptosis J:128225
increased urine protein level J:128225
kidney failure J:128225
polycystic kidney J:128225
premature death J:128225
renal interstitial fibrosis J:128225
Lama5tm3Jhm/Lama5tm3Jhm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		hematuria J:185850
increased urine protein level J:185850
polycystic kidney J:185850
premature death J:185850
Lama5tm3Jhm/Lama5tm3Jhm
Tg(Nphs1-flpo)1Jhm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		normal renal/urinary system phenotype J:185850
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory