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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdkn2c
cyclin dependent kinase inhibitor 2C
MGI:105388
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brca1tm1Bhk/Brca1+
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
C.129-Cdkn2ctm1Yxi Brca1tm1Bhk 		abnormal mammary gland morphology J:198018
increased mammary adenocarcinoma incidence J:198018
increased mammary gland tumor incidence J:198018
increased metastatic potential J:198018
Brca1tm1Bhk/Brca1tm1Bhk
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
C.129-Cdkn2ctm1Yxi Brca1tm1Bhk 		lethality throughout fetal growth and development, complete penetrance J:198018
Cdkn1btm1Ako/Cdkn1btm1Ako
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2 		ataxia J:50053
decreased tumor-free survival time J:50053
dehydration J:50053
enlarged adrenal glands J:50053
enlarged heart J:50053
enlarged pituitary gland J:50053
enlarged spleen J:50053
enlarged testis J:50053
enlarged thymus J:50053
increased carcinoma incidence J:50053
increased pituitary adenoma incidence J:50053
pituitary intermediate lobe hyperplasia J:50053
weight loss J:50053
Cdkn2btm1Bbd/Cdkn2btm1Bbd
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
involves: 129S1/Sv * C57BL/6 		abnormal cell physiology J:63299
abnormal Langerhans cell morphology J:63299
abnormal lymphocyte morphology J:63299
abnormal mammary gland morphology J:63299
abnormal testis morphology J:63299
dilated rete testis J:63299
enlarged spleen J:63299
enlarged testis J:63299
extramedullary hematopoiesis J:63299
increased fibroblast proliferation J:63299
increased lymphoma incidence J:63299
increased pituitary adenoma incidence J:63299
increased sarcoma incidence J:63299
increased testis tumor incidence J:63299
increased tumor incidence J:63299
kidney cyst J:63299
lymph node hyperplasia J:63299
lymphoid hyperplasia J:63299
pancreas cyst J:63299
seminiferous tubule degeneration J:63299
Cdkn2ctm1Bbd/Cdkn2c+
Trp53tm1Tyj/Trp53+
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		increased medulloblastoma incidence J:102702
Cdkn2ctm1Bbd/Cdkn2c+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		increased medulloblastoma incidence J:102702
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Cdkn2dtm1Maro/Cdkn2dtm1Maro
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal germ cell morphology J:68829
abnormal Leydig cell differentiation J:68829
abnormal male meiosis J:68829
abnormal spermatogenesis J:68829
asthenozoospermia J:68829
decreased circulating testosterone level J:68829
decreased germ cell number J:68829
increased body weight J:68829
increased circulating follicle stimulating hormone level J:68829
increased Leydig cell number J:68829
increased pheochromocytoma incidence J:68829
increased pituitary adenoma incidence J:68829
male infertility J:68829
oligozoospermia J:68829
seminiferous tubule degeneration J:68829
testicular atrophy J:68829
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal neuron differentiation J:102702
increased medulloblastoma incidence J:102702
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
increased medulloblastoma incidence J:205254
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:102702
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		abnormal neuron differentiation J:102702
increased medulloblastoma incidence J:102702
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Men1tm1.1Ctre/Men1+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		decreased tumor latency J:120835
increased adenocarcinoma incidence J:120835
increased adrenal gland tumor incidence J:120835
increased Leydig cell tumor incidence J:120835
increased lung adenocarcinoma incidence J:120835
increased lung adenoma incidence J:120835
increased lung tumor incidence J:120835
increased pancreas tumor incidence J:120835
increased parathyroid gland tumor incidence J:120835
increased testis tumor incidence J:120835
increased thyroid tumor incidence J:120835
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Men1tm1.1Ctre/Men1tm1.1Ctre
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		embryonic lethality, complete penetrance J:120835
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory