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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ednra
endothelin receptor type A
MGI:105923
125 phenotypes from 10 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ednram1Mhda/Ednra+
C3HeB/FeJ-Ednram1Mhda 		abnormal cranium morphology J:237903
abnormal incudomalleolar joint morphology J:237903
abnormal inspiratory capacity J:237903
abnormal malleus morphology J:237903
abnormal respiration J:237903
abnormal temporal bone petrous part morphology J:237903
abnormal temporal bone zygomatic process morphology J:237903
abnormal vital capacity J:237903
abnormal zygomatic bone morphology J:237903
absent incus short process J:237903
absent temporal bone zygomatic process J:237903
decreased prepulse inhibition J:237903
decreased startle reflex J:237903
impaired hearing J:237903
increased or absent threshold for auditory brainstem response J:237903
normal integument phenotype J:237903
malocclusion J:237903
micrognathia J:237903
short mandible J:237903
Ednram1Mhda/Ednram1Mhda
C3HeB/FeJ-Ednram1Mhda 		abnormal cranium morphology J:237903
abnormal ear shape J:237903
abnormal inspiratory capacity J:237903
abnormal jaw morphology J:237903
abnormal malleus morphology J:237903
abnormal mandibular condyloid process morphology J:237903
abnormal orbit morphology J:237903
abnormal outer ear helix morphology J:237903
abnormal respiration J:237903
abnormal temporal bone petrous part morphology J:237903
abnormal temporomandibular joint morphology J:237903
abnormal vital capacity J:237903
abnormal zygomatic arch morphology J:237903
abnormal zygomatic bone morphology J:237903
absent incus short process J:237903
absent temporal bone zygomatic process J:237903
conductive hearing loss J:237903
decreased body size J:237903
decreased body weight J:237903
decreased lung compliance J:237903
decreased prepulse inhibition J:237903
decreased startle reflex J:237903
decreased total lung capacity J:237903
increased or absent threshold for auditory brainstem response J:237903
normal integument phenotype J:237903
lowered ear position J:237903
macrophthalmia J:237903
malocclusion J:237903
micrognathia J:237903
prominent cheeks J:237903
round face J:237903
round orbits J:237903
short mandible J:237903
short snout J:237903
shortened head J:237903
wide coronal suture J:237903
wide lambdoid suture J:237903
wide sagittal suture J:237903
Ednratm1b(EUCOMM)Hmgu/Ednra+
C57BL/6N-Ednratm1b(EUCOMM)Hmgu/J 		cataract J:211773
Ednratm1b(EUCOMM)Hmgu/Ednratm1b(EUCOMM)Hmgu
C57BL/6N-Ednratm1b(EUCOMM)Hmgu/J 		abnormal craniofacial morphology J:211773
abnormal facial morphology J:211773
preweaning lethality, complete penetrance J:211773
Ednratm1Hku/Ednratm1Hku
involves: 129 * C57BL/6 * ICR 		abnormal alisphenoid bone morphology J:131382
abnormal alveolar process morphology J:131382
abnormal basisphenoid bone morphology J:131382
abnormal hyoid bone morphology J:131382
abnormal malleus morphology J:131382
abnormal palatine bone morphology J:131382
abnormal pterygoid process morphology J:131382
abnormal stapes morphology J:131382
abnormal temporal bone zygomatic process morphology J:131382
abnormal zygomatic bone morphology J:131382
absent gonial bone J:131382
absent temporal bone zygomatic process J:131382
absent tympanic ring J:131382
lower jaw to upper jaw transformation J:131382
perinatal lethality, complete penetrance J:131382
short styloid process J:131382
Ednratm1Hku/Ednratm2.1Hku
involves: 129 * C57BL/6 * ICR 		perinatal lethality, complete penetrance J:131382
Ednratm1Hku/Ednratm3(Ednrb)Hku
involves: 129 * C57BL/6 * ICR 		perinatal lethality, complete penetrance J:131382
Ednratm1Ywa/Ednratm1Ywa
129S/SvEv-Ednratm1Ywa 		abnormal cardiovascular system morphology J:46639
abnormal carotid artery morphology J:46639
abnormal dorsal aorta morphology J:46639
abnormal facial nerve morphology J:46639
abnormal first pharyngeal arch morphology J:46639
abnormal mandibular nerve branching J:46639
abnormal middle ear ossicle morphology J:46639
abnormal mouth morphology J:46639
abnormal muscle morphology J:46639
abnormal outer ear morphology J:46639
abnormal palate morphology J:46639
abnormal palatine bone morphology J:46639
abnormal pulmonary ventilation J:46639
abnormal skeleton morphology J:46639
abnormal styloid process morphology J:46639
abnormal trigeminal nerve morphology J:46639
absent incus J:46639
absent malleus J:46639
absent Meckel's cartilage J:46639
absent right subclavian artery J:46639
absent salivary gland J:46639
absent stapes J:46639
absent submandibular gland J:46639
absent tubotympanic recess J:46639
absent tympanic membrane J:46639
absent tympanic ring J:46639
aorta tubular hypoplasia J:46639
cleft chin J:46639
d-loop transposition of the great arteries J:46639
double outlet right ventricle J:46639
ectopic thymus J:46639
interrupted aorta J:46639
mandible hypoplasia J:46639
overriding aortic valve J:46639
patent ductus arteriosus J:46639
perimembraneous ventricular septal defect J:46639
perinatal lethality, complete penetrance J:46639
persistent truncus arteriosus J:46639
small second pharyngeal arch J:46639
small zygomatic bone J:46639
thymus hypoplasia J:46639
tongue hypoplasia J:46639
Ednratm1Ywa/Ednratm1Ywa
involves: 129S7/SvEvBrd 		abnormal alisphenoid bone morphology J:93183
abnormal mandible morphology J:93183
abnormal maxilla morphology J:93183
abnormal Meckel's cartilage morphology J:93183
abnormal mouth floor morphology J:93183
abnormal palatine bone morphology J:93183
absent gonial bone J:93183
absent tympanic ring J:93183
lower jaw to upper jaw transformation J:93183
small zygomatic bone J:93183
Ednratm1Ywa/Ednratm1Ywa
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		aberrant origin of the right subclavian artery J:48566
abnormal artery morphology J:48566
abnormal ascending aorta morphology J:48566
abnormal fourth pharyngeal arch artery morphology J:48566
abnormal pharyngeal arch artery morphology J:48566
abnormal sixth pharyngeal arch artery morphology J:48566
abnormal third pharyngeal arch artery morphology J:48566
double aortic arch J:48566
double outlet right ventricle J:48566
overriding aortic valve J:48566
persistent right 6th pharyngeal arch artery J:48566
persistent right dorsal aorta J:48566
persistent truncus arteriosus J:48566
Ednratm2.1Hku/Ednratm2.1Hku
involves: 129 * C57BL/6 * ICR 		abnormal temporal bone morphology J:224515
absent Meckel's cartilage J:224515
perinatal lethality, complete penetrance J:131382
Ednratm2.1Hku/Ednratm3(Ednrb)Hku
involves: 129 * C57BL/6 * ICR 		abnormal craniofacial bone morphology J:131382
abnormal hyoid bone morphology J:131382
abnormal mandible morphology J:131382
lower jaw to upper jaw transformation J:131382
perinatal lethality, complete penetrance J:131382
Ednratm2.1Hku/Ednratm4(Ednra)Hku
involves: 129 * C57BL/6 * ICR 		normal craniofacial phenotype J:131382
Ednratm2.1Hku/Ednratm5Hku
involves: 129 * C57BL/6 * ICR 		abnormal heart development J:166932
abnormal heart morphology J:166932
abnormal heart ventricle morphology J:166932
Ednratm2Hku/Ednratm2Hku
involves: 129 * C57BL/6 * ICR 		perinatal lethality, complete penetrance J:131382
Ednratm2Hku/Ednratm3(Ednrb)Hku
involves: 129 * C57BL/6 * ICR 		abnormal craniofacial bone morphology J:131382
abnormal hyoid bone morphology J:131382
abnormal mandible morphology J:131382
perinatal lethality, complete penetrance J:131382
Ednratm2Ywa/Ednratm2Ywa
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		no abnormal phenotype detected J:86476
Ednratm2Ywa/Ednratm2Ywa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:149166
abnormal craniofacial morphology J:149166
abnormal incisor morphology J:149166
abnormal incus morphology J:149166
abnormal malleus morphology J:149166
abnormal mandible morphology J:149166
abnormal mouth floor morphology J:149166
abnormal stapes morphology J:149166
absent incus J:149166
absent malleus J:149166
absent Meckel's cartilage J:149166
facial cleft J:149166
short mandible J:149166
tongue hypoplasia J:149166
Ednratm2Ywa/Ednratm2Ywa
Tg(Aqp2-cre)1Dek/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal urine osmolality J:101241
normal homeostasis/metabolism phenotype J:101241
increased circulating antidiuretic hormone level J:101241
normal renal/urinary system phenotype J:101241
Ednratm2Ywa/Ednratm2Ywa
Tg(AQP2-cre)2Dek/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		normal cardiovascular system phenotype J:116002
no abnormal phenotype detected J:116002
Ednratm2Ywa/Ednratm2Ywa
Tg(Hand2-cre)7-1Clou/0
involves: C57BL/6J * SJL 		normal craniofacial phenotype J:149166
Ednratm2Ywa/Ednratm2Ywa
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		no abnormal phenotype detected J:86476
Ednratm3(Ednrb)Hku/Ednratm3(Ednrb)Hku
involves: 129 * C57BL/6 * ICR 		abnormal craniofacial bone morphology J:131382
abnormal hyoid bone morphology J:131382
abnormal mandible morphology J:131382
perinatal lethality, complete penetrance J:131382
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory