Psmc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
MGI:106054

20 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Psmc1^tm1.1Maye/Psmc1^tm1.1Maye involves: 129 * CD-1	prenatal lethality, complete penetrance	J:138991
Psmc1^tm1Maye/Psmc1^tm1.1Maye Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * CD-1	abnormal noradrenaline level	J:138991
	alpha-synuclein inclusion body	J:138991
	decreased body size	J:138991
	decreased dopamine level	J:138991
	gliosis	J:138991
	neuron degeneration	J:138991
	postnatal lethality	J:138991
Psmc1^tm1Maye/Psmc1^tm1Maye Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-cre)1Lin/0 involves: 129 * C57BL/6 * CD-1	abnormal eating behavior	J:138991
	abnormal fear/anxiety-related behavior	J:138991
	abnormal spatial learning	J:138991
	alpha-synuclein inclusion body	J:138991
	enlarged brain ventricles	J:138991
	forebrain atrophy	J:138991
	gliosis	J:138991
	increased neuron apoptosis	J:138991
	loss of cortex neurons	J:138991
	neurodegeneration	J:138991
	postnatal growth retardation	J:138991
	premature death	J:138991
	thin cerebral cortex	J:138991
Psmc1^tm1Maye/Psmc1^tm1Maye Th^tm1(cre)Te/Th⁺ involves: 129X1/SvJ * CD-1	abnormal noradrenaline level	J:138991
	alpha-synuclein inclusion body	J:138991
	decreased body size	J:138991
	decreased dopamine level	J:138991
	gliosis	J:138991
	neuron degeneration	J:138991
	postnatal lethality, complete penetrance	J:138991

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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