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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
MGI:106091
45 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cyp7a1tm1b(EUCOMM)Wtsi/Cyp7a1tm1b(EUCOMM)Wtsi
C57BL/6N-Cyp7a1tm1b(EUCOMM)Wtsi/Ieg 		abnormal lens morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina morphology J:211773
abnormal retina vasculature morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
decreased blood urea nitrogen level J:211773
decreased circulating iron level J:211773
decreased circulating serum albumin level J:211773
decreased exploration in new environment J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating bilirubin level J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
increased circulating unsaturated transferrin level J:211773
increased leukocyte cell number J:211773
increased startle reflex J:211773
persistence of hyaloid vascular system J:211773
Cyp7a1tm1Rus/Cyp7a1tm1Rus
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal bile composition J:34870
abnormal bile salt homeostasis J:34342
abnormal bile salt level J:34870
abnormal epidermis stratum basale morphology J:34342
abnormal epidermis stratum granulosum morphology J:34342
abnormal fat-soluble vitamin level J:34342, J:34870
abnormal lipid homeostasis J:34870
abnormal liver morphology J:34342
abnormal liver physiology J:34342
abnormal skin condition J:34342
abnormal skin morphology J:34342
abnormal vision J:34342
decreased birth weight J:34342
decreased exploration in new environment J:34342
decreased intestinal cholesterol absorption J:114411
decreased locomotor activity J:34342
delayed eyelid opening J:34342
dry skin J:34342
flaky skin J:34342
greasy coat J:34342
hyperkeratosis J:34342
oily skin J:34342
perinatal lethality, incomplete penetrance J:34342
postnatal growth retardation J:34342
postnatal lethality, incomplete penetrance J:34342
steatorrhea J:34342
thin dermal layer J:34342
thin epidermis stratum spinosum J:34342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory