Npm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Npm1
nucleophosmin 1
MGI:106184

63 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj}/Gt(ROSA)26Sor⁺ Npm1^tm1Trow/Npm1⁺ B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj} Npm1^tm1Trow	abnormal bone marrow cell physiology	J:272803
	abnormal bone marrow hematopoietic cell morphology	J:272803
	decreased hematopoietic stem cell number	J:272803
	increased granulocyte monocyte progenitor cell number	J:272803
Npm1^{Gt(OST331547)Lex}/Npm1⁺ B6;129S5-Npm1^{Gt(OST331547)Lex}/Mmucd	abnormal hematopoietic stem cell physiology	J:188985
	normal hematopoietic system phenotype	J:188985
	increased hematopoietic stem cell number	J:188985
Npm1^{Gt(OST331547)Lex}/Npm1^{Gt(OST331547)Lex} B6;129S5-Npm1^{Gt(OST331547)Lex}/Mmucd	embryonic lethality, complete penetrance	J:188985
Npm1^{Gt(OST331547)Lex}/Npm1^{Gt(OST331547)Lex} involves: 129S5/SvEvBrd * C57BL/6J	neonatal lethality, complete penetrance	J:103485
Npm1^{Gt(VICTR37)704Lex}/Npm1^{Gt(VICTR37)704Lex} involves: 129S5/SvEvBrd * C57BL/6	abnormal cell proliferation	J:101353
	abnormal placenta development	J:101353
	decreased embryo size	J:101353
	normal embryo phenotype	J:101353
	embryonic growth arrest	J:101353
	embryonic lethality during organogenesis, complete penetrance	J:101353
	increased apoptosis	J:101353
	increased fibroblast apoptosis	J:101353
Npm1^tm1Gsva/Npm1⁺ Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal common myeloid progenitor cell morphology	J:172071
	decreased B cell number	J:172071
	enlarged liver	J:172071
	enlarged spleen	J:172071
	increased acute promyelocytic leukemia incidence	J:172071
	increased B cell derived lymphoma incidence	J:172071
	increased granulocyte number	J:172071
	increased leukocyte cell number	J:172071
	increased liver weight	J:172071
	increased mean corpuscular volume	J:172071
	increased mean platelet volume	J:172071
	increased spleen weight	J:172071
	premature death	J:172071
Npm1^tm1Gsva/Npm1^tm1Gsva Dppa3^tm1(cre)Peli/Dppa3⁺ involves: 129S5/SvEvBrd * 129S7/SvEvBrd	embryonic lethality, complete penetrance	J:172071
Npm1^tm1Hft/Npm1⁺ involves: 129	abnormal bone marrow cell morphology/development	J:194999
	abnormal common myeloid progenitor cell morphology	J:194999
	abnormal granulocyte differentiation	J:194999
	abnormal spleen B cell follicle morphology	J:194999
	enlarged spleen	J:194999
	extramedullary hematopoiesis	J:194999
	normal hematopoietic system phenotype	J:194999
	increased granulocyte number	J:194999
	increased hematopoietic stem cell number	J:194999
	increased leukocyte cell number	J:194999
	increased monocyte cell number	J:194999
	increased spleen weight	J:194999
	myeloid hyperplasia	J:194999
	normal neoplasm	J:194999
	thrombocytosis	J:194999
Npm1^tm1Hft/Npm1^tm1Hft involves: 129	embryonic lethality, complete penetrance	J:194999
Npm1^tm1Ppp/Npm1⁺ involves: 129S1/Sv * C57BL/6	abnormal cell proliferation	J:101494
	abnormal megakaryocyte morphology	J:101494
	abnormal proerythroblast morphology	J:101494
	abnormal thrombopoiesis	J:101494
	anisocytosis	J:101494
	chromosome breakage	J:101494
	increased bone marrow cell number	J:101494
	increased mean corpuscular volume	J:101494
	lethality throughout fetal growth and development, incomplete penetrance	J:101494
	reticulocytopenia	J:101494
Npm1^tm1Ppp/Npm1^tm1Ppp involves: 129S1/Sv * C57BL/6	abnormal brain morphology	J:101494
	abnormal cell cycle	J:101494
	abnormal embryonic hematopoiesis	J:101494
	abnormal visceral yolk sac blood island morphology	J:101494
	absent forebrain	J:101494
	absent liver	J:101494
	absent vitelline blood vessels	J:101494
	anemia	J:101494
	anophthalmia	J:101494
	decreased embryo size	J:101494
	decreased fibroblast proliferation	J:101494
	embryonic lethality during organogenesis, complete penetrance	J:101494
	increased embryonic tissue cell apoptosis	J:101494
	pallor	J:101494
	small placenta	J:101494
Npm1^tm2Ppp/Npm1^tm2Ppp involves: 129S1/Sv * C57BL/6	abnormal embryonic hematopoiesis	J:101494
	abnormal eye development	J:101494
	abnormal forebrain development	J:101494
	abnormal vitelline vasculature morphology	J:101494
	anemia	J:101494
	chromosome breakage	J:101494
	decreased embryo size	J:101494
	decreased fibroblast proliferation	J:101494
	lethality throughout fetal growth and development, complete penetrance	J:101494
	pallor	J:101494

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