Bcl11a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl11a
BCL11 transcription factor A
MGI:106190

37 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bcl11a^tm1.1Pwt/Bcl11a^tm1.1Pwt Not Specified	abnormal erythropoiesis	J:151995
Bcl11a^tm1.1Pwt/Bcl11a^tm1.1Pwt Not Specified	abnormal hemoglobin content	J:151995
Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri involves: BALB/cJ	neonatal lethality, complete penetrance	J:184011
Bcl11a^tm1Ngc/Bcl11a⁺ involves: 129S1/Sv	abnormal common lymphocyte progenitor cell morphology	J:194616
	abnormal T cell differentiation	J:194616
	decreased DN2 thymocyte number	J:194616
	decreased hematopoietic stem cell number	J:194616
	decreased lymphocyte cell number	J:207383
Bcl11a^tm1Ngc/Bcl11a^tm1Ngc involves: 129S1/Sv * C57BL/6J	abnormal dendritic cell differentiation	J:207383
	abnormal immunoglobulin heavy chain V(D)J recombination	J:83646
	absent B cells	J:83646, J:207383
	absent CD4-positive, alpha-beta T cells	J:83646
	absent lymphocyte	J:207383
	decreased plasmacytoid dendritic cell number	J:207383
	decreased T cell number	J:83646
	increased CD8-positive, alpha-beta T cell number	J:83646
	increased double-negative T cell number	J:83646
	increased gamma-delta T cell number	J:83646
	neonatal lethality, complete penetrance	J:83646
	small thymus	J:83646
	thymus hypoplasia	J:83646
Bcl11a^tm1Peli/Bcl11a^tm1Peli Not Specified	normal hematopoietic system phenotype	J:194616
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6 * C57BL/10 * CBA/Ca	decreased B cell number	J:207383
	decreased circulating interferon-alpha level	J:207383
	decreased hematopoietic stem cell number	J:207383
	decreased plasmacytoid dendritic cell number	J:207383
	normal hematopoietic system phenotype	J:207383
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ involves: BALB/cJ	normal hematopoietic system phenotype	J:196140
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	decreased leukocyte cell number	J:196140
	normal hematopoietic system phenotype	J:196140
Bcl11a^tm1Sbri/Bcl11a^tm1Sbri Tg(PLAT-cre)116Sdu/0 Not Specified	normal nervous system phenotype	J:184011
Bcl11a^tm1Sbri/Bcl11a^tm1Sbri Tg(Pou3f4-cre)32Cren/0 involves: CD-1	abnormal axon morphology	J:184011
	abnormal excitatory postsynaptic currents	J:184011
	abnormal neurite morphology	J:184011
	abnormal neuron differentiation	J:184011
	abnormal sensory neuron innervation pattern	J:184011
	abnormal spinal cord dorsal horn morphology	J:184011
Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S1/Sv	abnormal common lymphocyte progenitor cell morphology	J:194616
	abnormal hematopoietic stem cell physiology	J:194616
	abnormal immune system morphology	J:194616
	abnormal T cell differentiation	J:194616
	decreased B cell number	J:194616
	decreased DN2 thymocyte number	J:194616
	decreased hematopoietic stem cell number	J:194616
	decreased immature B cell number	J:194616
	decreased pre-B cell number	J:194616
	decreased pro-B cell number	J:194616
	increased B cell apoptosis	J:194616

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24