Bcl11a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl11a
BCL11 transcription factor A
MGI:106190

37 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bcl11a^tm1.1Pwt/Bcl11a^tm1.1Pwt Not Specified	abnormal erythropoiesis	J:151995
Bcl11a^tm1.1Pwt/Bcl11a^tm1.1Pwt Not Specified	abnormal hemoglobin content	J:151995
Bcl11a^tm1.1Sbri/Bcl11a^tm1.1Sbri involves: BALB/cJ	neonatal lethality, complete penetrance	J:184011
Bcl11a^tm1Ngc/Bcl11a⁺ involves: 129S1/Sv	abnormal common lymphocyte progenitor cell morphology	J:194616
	abnormal T cell differentiation	J:194616
	decreased DN2 thymocyte number	J:194616
	decreased hematopoietic stem cell number	J:194616
	decreased lymphocyte cell number	J:207383
Bcl11a^tm1Ngc/Bcl11a^tm1Ngc involves: 129S1/Sv * C57BL/6J	abnormal dendritic cell differentiation	J:207383
	abnormal immunoglobulin heavy chain V(D)J recombination	J:83646
	absent B cells	J:83646, J:207383
	absent CD4-positive, alpha-beta T cells	J:83646
	absent lymphocyte	J:207383
	decreased plasmacytoid dendritic cell number	J:207383
	decreased T cell number	J:83646
	increased CD8-positive, alpha-beta T cell number	J:83646
	increased double-negative T cell number	J:83646
	increased gamma-delta T cell number	J:83646
	neonatal lethality, complete penetrance	J:83646
	small thymus	J:83646
	thymus hypoplasia	J:83646
Bcl11a^tm1Peli/Bcl11a^tm1Peli Not Specified	normal hematopoietic system phenotype	J:194616
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6 * C57BL/10 * CBA/Ca	decreased B cell number	J:207383
	decreased circulating interferon-alpha level	J:207383
	decreased hematopoietic stem cell number	J:207383
	decreased plasmacytoid dendritic cell number	J:207383
	normal hematopoietic system phenotype	J:207383
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ involves: BALB/cJ	normal hematopoietic system phenotype	J:196140
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	decreased leukocyte cell number	J:196140
	normal hematopoietic system phenotype	J:196140
Bcl11a^tm1Sbri/Bcl11a^tm1Sbri Tg(PLAT-cre)116Sdu/0 Not Specified	normal nervous system phenotype	J:184011
Bcl11a^tm1Sbri/Bcl11a^tm1Sbri Tg(Pou3f4-cre)32Cren/0 involves: CD-1	abnormal axon morphology	J:184011
	abnormal excitatory postsynaptic currents	J:184011
	abnormal neurite morphology	J:184011
	abnormal neuron differentiation	J:184011
	abnormal sensory neuron innervation pattern	J:184011
	abnormal spinal cord dorsal horn morphology	J:184011
Bcl11a^tm2.1Peli/Bcl11a^tm2.1Peli Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S1/Sv	abnormal common lymphocyte progenitor cell morphology	J:194616
	abnormal hematopoietic stem cell physiology	J:194616
	abnormal immune system morphology	J:194616
	abnormal T cell differentiation	J:194616
	decreased B cell number	J:194616
	decreased DN2 thymocyte number	J:194616
	decreased hematopoietic stem cell number	J:194616
	decreased immature B cell number	J:194616
	decreased pre-B cell number	J:194616
	decreased pro-B cell number	J:194616
	increased B cell apoptosis	J:194616

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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