Nrp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nrp1
neuropilin 1
MGI:106206

61 phenotypes from 7 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nrp1^tm1.1Cruh/Nrp1^tm1.1Cruh involves: C57BL/6	abnormal retina blood vessel pattern	J:176047
Nrp1^tm1.1Cruh/Nrp1^tm1.1Cruh involves: C57BL/6	normal cardiovascular system phenotype	J:176047
Nrp1^tm1.1Izac/Nrp1^tm1.1Izac involves: 129S2/SvPas * C57BL/6	abnormal brain vasculature morphology	J:208348
	abnormal coronary artery morphology	J:208348
	abnormal coronary vessel morphology	J:208348
	abnormal induced retina neovascularization	J:208348
	abnormal retina blood vessel morphology	J:208348
	abnormal retina vasculature morphology	J:208348
	decreased angiogenesis	J:208348
	decreased body size	J:208348
	decreased tumor growth/size	J:208348
	postnatal lethality, incomplete penetrance	J:208348
	premature death	J:208348
	vascular smooth muscle hypoplasia	J:208348
Nrp1^{tm1b(EUCOMM)Hmgu}/Nrp1⁺ C57BL/6N-Nrp1^{tm1b(EUCOMM)Hmgu}/Orl	abnormal auditory brainstem response	J:211773
	decreased prepulse inhibition	J:211773
Nrp1^{tm1b(EUCOMM)Hmgu}/Nrp1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Nrp1^{tm1b(EUCOMM)Hmgu}/Orl	preweaning lethality, complete penetrance	J:211773
Nrp1^tm1Ddg/Nrp1^tm1Ddg involves: 129P2/OlaHsd	abnormal dendritic cell physiology	J:161856
	abnormal T cell physiology	J:161856
	normal vision/eye phenotype	J:172268
Nrp1^tm1Ddg/Nrp1^tm1Ddg involves: 129P2/OlaHsd * C57BL/6	abnormal axon guidance	J:93799
	abnormal corpus callosum morphology	J:93799
	abnormal cranial nerve morphology	J:93799
	abnormal dorsal root ganglion morphology	J:93799
	abnormal hippocampus morphology	J:93799
	abnormal spinal nerve morphology	J:93799
	abnormal trigeminal nerve morphology	J:93799
	abnormal vestibulocochlear nerve morphology	J:93799
	dilated heart atrium	J:93799
	postnatal growth retardation	J:93799
	postnatal lethality	J:93799
Nrp1^tm1Ddg/Nrp1^tm1Ddg Tg(Thy1-YFP)16Jrs/0 involves: 129P2/OlaHsd * C57BL/6	abnormal cerebral cortex pyramidal cell morphology	J:93799
Nrp1^tm1Hfu/Nrp1^tm1Hfu involves: C57BL/6 * CBA	abnormal axon guidance	J:98330
	abnormal spinal nerve morphology	J:98330
	abnormal trigeminal nerve morphology	J:98330
	abnormal vascular development	J:75477
	embryonic lethality during organogenesis, complete penetrance	J:75477
	transposition of great arteries	J:75477
Nrp1^tm1Hfu/Nrp1^tm1Hfu involves: C57BL/6 * CBA * ICR	abnormal aortic arch and aortic arch branch attachment	J:58077
	abnormal dorsal aorta morphology	J:58077
	abnormal first pharyngeal arch artery morphology	J:58077
	abnormal fourth pharyngeal arch artery morphology	J:58077
	abnormal pharyngeal arch artery morphology	J:58077
	abnormal pulmonary artery morphology	J:58077
	abnormal second pharyngeal arch artery morphology	J:58077
	abnormal sixth pharyngeal arch artery morphology	J:58077
	abnormal third pharyngeal arch artery morphology	J:58077
	decreased angiogenesis	J:58077
	disorganized yolk sac vascular plexus	J:58077
	double aortic arch	J:58077
	embryonic lethality, complete penetrance	J:58077
	persistent truncus arteriosus	J:58077
	right aortic arch	J:58077
Nrp1^tm1Hfu/Nrp1^tm1Hfu involves: C57BL/6NCrlj * CBA/JNCrlj	normal nervous system phenotype	J:175836
Nrp1^tm1Hfu/Nrp1^tm1Hfu involves: CD-1 * JF1	abnormal facial motor nucleus morphology	J:94050
	abnormal facial nerve morphology	J:94050
	abnormal trigeminal nerve morphology	J:94050
	delayed neuronal migration	J:94050
Nrp1^tm1Hfu/Nrp1^tm2Ddg Tg(Tek-cre)1Ywa/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	abnormal brain vasculature morphology	J:175836
	decreased gonadotropin-releasing hormone neuron number	J:175836
Nrp1^tm2.1Ddg/Nrp1^tm2.1Ddg involves: 129 * C57BL/6	abnormal spinal nerve morphology	J:93799
Nrp1^tm2.1Ddg/Nrp1^tm2.1Ddg involves: 129 * C57BL/6	abnormal trigeminal nerve morphology	J:93799
Nrp1^tm2Ddg/Nrp1^tm2.1Ddg Tg(Gucy2g-cre,-EGFP)52Irod/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal accessory olfactory bulb morphology	J:185650
	normal nervous system phenotype	J:185650
Nrp1^tm2Ddg/Nrp1^tm2.1Ddg Tg(Tek-cre)1Ywa/0 involves: 129 * C57BL/6	abnormal blood vessel morphology	J:93799
	dilated heart atrium	J:93799
	failure of vascular branching	J:93799
	persistent truncus arteriosus	J:93799
	prenatal lethality, complete penetrance	J:93799
Nrp1^tm2Ddg/Nrp1^tm2Ddg Tg(Tek-cre)1Ywa/0 involves: 129 * C57BL/6	abnormal cardiovascular system morphology	J:93799
	abnormal coronary vessel morphology	J:93799
	perinatal lethality, complete penetrance	J:93799
	persistent truncus arteriosus	J:93799
	ventricular septal defect	J:93799

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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