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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdc42
cell division cycle 42
MGI:106211
153 phenotypes from 8 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdc42Gt(Ex160)Byg/Cdc42Gt(Ex160)Byg
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality between implantation and somite formation, complete penetrance J:70273
Cdc42tm1.1Ayam/Cdc42tm1.1Ayam
Tg(Mpz-cre)94Imeg/0
Not Specified 		abnormal craniofacial bone morphology J:250065
abnormal frontal bone morphology J:250065
abnormal mandible morphology J:250065
abnormal medial nasal prominence morphology J:250065
abnormal nasal bone morphology J:250065
abnormal nasal septum morphology J:250065
abnormal premaxilla morphology J:250065
abnormal secondary palate development J:250065
absent gastric milk in neonates J:250065
absent palatal shelf J:250065
cleft palate J:250065
facial cleft J:250065
failure of palatal shelf elevation J:250065
intracranial hemorrhage J:250065
maxillary shelf hypoplasia J:250065
neonatal lethality, incomplete penetrance J:250065
palatine bone horizontal plate hypoplasia J:250065
short maxilla J:250065
short premaxilla J:250065
short snout J:250065
Cdc42tm1.1Ayam/Cdc42tm1.1Ayam
Tg(Prrx1-cre)1Cjt/0
involves: 129P2/OlaHsd * C57BL/6 * ICR * SJL 		abnormal autopod joint morphology J:184022
abnormal autopod morphology J:184022
abnormal cartilage development J:184022
abnormal interdigital cell death J:184022
abnormal intramembranous bone ossification J:184022
abnormal joint morphology J:184022
abnormal limb bone morphology J:184022
abnormal limb morphology J:184022
abnormal long bone epiphyseal plate morphology J:184022
abnormal palatal shelf morphology J:184022
abnormal suckling behavior J:184022
abnormal xiphoid process morphology J:184022
brachydactyly J:184022
cleft palate J:184022
decreased birth body size J:184022
decreased body length J:184022
delayed fontanelle closure J:184022
disorganized long bone epiphyseal plate J:184022
fused metacarpal bones J:184022
fused phalanges J:184022
increased width of hypertrophic chondrocyte zone J:184022
interdigital webbing J:184022
neonatal lethality, incomplete penetrance J:184022
postnatal lethality, incomplete penetrance J:184022
short limbs J:184022
split sternum J:184022
syndactyly J:184022
weakness J:184022
Cdc42tm1.1Rac/Cdc42tm1.1Rac
involves: 129P2/OlaHsd * FVB/N 		no abnormal phenotype detected J:197886
Cdc42tm1.1Rac/Cdc42tm1.1Rac
Tg(GFAP-cre)25Mes/0
involves: 129P2/OlaHsd * FVB/N 		abnormal brain ependyma morphology J:197886
abnormal brain ventricle morphology J:197886
absent brain ependyma motile cilia J:197886
domed cranium J:197886
enlarged lateral ventricles J:197886
enlarged third ventricle J:197886
hydrocephaly J:197886
premature death J:197886
thin cerebral cortex J:197886
Cdc42tm1.1Rac/Cdc42tm1.1Rac
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		abnormal brain ependyma morphology J:197886
abnormal cell nucleus morphology J:197886
abnormal cerebral aqueduct morphology J:197886
abnormal cerebral cortex morphology J:197886
abnormal cortical plate morphology J:197886
abnormal cortical ventricular zone morphology J:197886
abnormal glial cell morphology J:197886
abnormal lateral ventricle morphology J:197886
abnormal neocortex morphology J:197886
abnormal neuronal precursor proliferation J:197886
abnormal spinal cord central canal morphology J:197886
abnormal third ventricle morphology J:197886
absent gastric milk in neonates J:197886
cerebral aqueductal stenosis J:197886
decreased cortical ventricular zone cell density J:197886
decreased locomotor activity J:197886
decreased neuronal precursor cell number J:197886
enlarged brain ventricles J:197886
intraventricular hemorrhage J:197886
postnatal lethality, complete penetrance J:197886
respiratory distress J:197886
small olfactory bulb J:197886
thin cerebral cortex J:197886
Cdc42tm1.1Yizh/Cdc42+
Not Specified 		decreased heart ventricle muscle contractility J:174208
Cdc42tm1b(EUCOMM)Hmgu/Cdc42+
C57BL/6N-Cdc42tm1b(EUCOMM)Hmgu/H 		abnormal cranium morphology J:211773
abnormal retina morphology J:211773
cornea opacity J:211773
decreased circulating serum albumin level J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin concentration J:211773
enlarged kidney J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
Cdc42tm1b(EUCOMM)Hmgu/Cdc42tm1b(EUCOMM)Hmgu
C57BL/6N-Cdc42tm1b(EUCOMM)Hmgu/H 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Cdc42tm1Brak/Cdc42tm1Brak
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * C57BL/6 		abnormal crypts of Lieberkuhn morphology J:184563
absent Paneth cells J:184563
Cdc42tm1Brak/Cdc42tm1Brak
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * C57BL/6J 		abnormal kidney cortex morphology J:195266
abnormal kidney development J:195266
abnormal kidney papilla morphology J:195266
abnormal nephrogenic zone morphology J:195266
abnormal proximal convoluted tubule morphology J:195266
anuria J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
postnatal lethality, complete penetrance J:195266
renal hypoplasia J:195266
Cdc42tm1Brak/Cdc42tm1Brak
Tg(KRT5-cre)5132Jlj/0
involves: C57BL/6J * DBA/2J 		abnormal epidermal layer morphology J:105811
abnormal epidermis stratum corneum morphology J:105811
abnormal hair follicle matrix region morphology J:105811
abnormal hair follicle morphology J:105811
abnormal hair shaft morphology J:105811
abnormal keratinocyte morphology J:105811
absent hair follicle inner root sheath J:105811
dermal cyst J:105811
epidermal hyperplasia J:105811
hyperkeratosis J:105811
postnatal growth retardation J:105811
Cdc42tm1Brak/Cdc42tm1Brak
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)LC1Bjd/0
involves: BALB/c * C57BL/6 * DBA 		abnormal renal tubule epithelium morphology J:221423
increased susceptibility to kidney reperfusion injury J:221423
Cdc42tm1Brak/Cdc42tm1Brak
Tg(Pf4-icre)Q3Rsko/0
involves: 129 * C57BL/6 		abnormal platelet activation J:160792
abnormal platelet dense granule physiology J:160792
abnormal platelet morphology J:160792
abnormal platelet physiology J:160792
increased bleeding time J:160792
increased platelet aggregation J:160792
increased susceptibility to induced thrombosis J:160792
thrombocytopenia J:160792
Cdc42tm1Brak/Cdc42tm1Brak
Tg(Plp1-cre/ERT2)1Ueli/0
involves: C57BL/6 * DBA/2 		abnormal myelin sheath morphology J:190437
Cdc42tm1Brak/Cdc42tm1Brak
Tg(Vil1-cre)997Gum/0
involves: C57BL/6J * SJL 		abnormal anus morphology J:184563
abnormal crypts of Lieberkuhn morphology J:184563
abnormal defecation J:184563
abnormal enterocyte morphology J:184563
abnormal intestinal enteroendocrine cell morphology J:184563
abnormal intestinal epithelium morphology J:184563
abnormal intestinal goblet cell morphology J:184563
abnormal intestine morphology J:184563
abnormal intestine physiology J:184563
abnormal small intestinal crypt cell physiology J:184563
decreased body size J:184563
decreased Paneth cell number J:184563
increased small intestinal crypt cell apoptosis J:184563
intestinal edema J:184563
postnatal growth retardation J:184563
premature death J:184563
Cdc42tm1Fwa/Cdc42tm1Fwa
involves: 129S6/SvEvTac 		abnormal actin cytoskeleton morphology J:63261
absent embryonic epiblast J:63261
decreased embryo size J:63261
disorganized embryonic tissue J:63261
embryonic lethality between implantation and somite formation, complete penetrance J:63261
Cdc42tm1Yizh/Cdc42tm1Yizh
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd 		abnormal embryonic neuroepithelium morphology J:116100
abnormal eye development J:116100
abnormal folding of telencephalic vesicles J:116100
abnormal telencephalon development J:116100
holoprosencephaly J:116100
lethality throughout fetal growth and development, complete penetrance J:116100
small embryonic telencephalon J:116100
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory