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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI:106299
61 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slx4m1Btlr/Slx4m1Btlr
C57BL/6J-Slx4m1Btlr 		decreased body weight J:236683
Slx4tm1.2Jrou/Slx4tm1.2Jrou
B6.129P2-Slx4tm1.2Jrou 		abnormal DNA repair J:204996
embryonic lethality, incomplete penetrance J:204996
increased sensitivity to induced cell death J:204996
induced chromosome breakage J:204996
preweaning lethality, incomplete penetrance J:204996
small testis J:204996
Slx4tm1.2Jrou/Slx4tm1.2Jrou
involves: 129P2/OlaHsd * C57BL/6 		preweaning lethality, complete penetrance J:204996
Slx4tm1a(EUCOMM)Wtsi/Slx4+
B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi 		increased bone mineral density J:165965
Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi 		abnormal cornea morphology J:165965
abnormal cranium morphology J:175295
abnormal eye morphology J:165965
abnormal eye size J:165965, J:175295
abnormal placement of pupils J:165965
anophthalmia J:175295
cornea opacity J:165965
decreased body weight J:165965
thrombocytopenia J:165965
Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
C57BL/6N-Slx4tm1a(EUCOMM)Wtsi 		abnormal cerebral cortex morphology J:168567
abnormal cornea morphology J:168567
abnormal cranium morphology J:168567
abnormal eye morphology J:168567
abnormal eyelid aperture J:168567
abnormal iris morphology J:168567
abnormal lymphopoiesis J:168567
abnormal male germ cell apoptosis J:168567
abnormal primordial germ cell morphology J:168567
abnormal pupil morphology J:168567
abnormal retina vasculature morphology J:168567
abnormal spermatogenesis J:168567
abnormal spine curvature J:168567
abnormal third ventricle morphology J:168567
abnormal tooth morphology J:168567
absent corpus luteum J:168567
absent mature ovarian follicles J:168567
absent oocytes J:168567
absent optic nerve J:168567
anophthalmia J:168567
azoospermia J:168567
chromosomal instability J:168567
cornea opacity J:168567
decreased body size J:168567
decreased body weight J:168567
decreased common myeloid progenitor cell number J:168567
decreased leukocyte cell number J:168567
decreased litter size J:168567
dilated lateral ventricle J:168567
domed cranium J:168567
early cellular replicative senescence J:168567
enlarged cranium J:168567
hydrocephaly J:168567
impaired glucose tolerance J:168567
increased caudal vertebrae number J:168567
increased circulating glucose level J:168567
increased erythrocyte cell number J:168567
increased physiological sensitivity to xenobiotic J:188123
increased sensitivity to induced cell death J:188123
lethality throughout fetal growth and development, incomplete penetrance J:168567
microphthalmia J:168567
normal nervous system phenotype J:168567
obstructive hydrocephaly J:168567
oligozoospermia J:168567
perinatal lethality, incomplete penetrance J:168567
postnatal growth retardation J:168567
reduced female fertility J:168567
reduced male fertility J:168567
thin cerebral cortex J:168567
thrombocytopenia J:168567
vertebral fusion J:168567
Slx4tm1Jrou/Slx4tm1Jrou
Not Specified 		abnormal telomere morphology J:202845
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory