Zranb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Zranb1
zinc finger, RAN-binding domain containing 1
MGI:106441

18 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Zranb1^em1Shios/Zranb1^em1Shios involves: C57BL/6	abnormal colon goblet cell morphology	J:333468
	decreased body size	J:333468
	decreased body weight	J:333468
	decreased intestinal mucosa thickness	J:333468
	normal digestive/alimentary phenotype	J:333468
	normal embryo phenotype	J:333468
	increased susceptibility to colitis induced morbidity/mortality	J:333468
Zranb1^{tm1a(EUCOMM)Hmgu}/Zranb1^{tm1a(EUCOMM)Hmgu} C57BL/6N-Zranb1^{tm1a(EUCOMM)Hmgu}/Ics	increased lean body mass	J:211773
	thrombocytosis	J:211773
Zranb1^{tm1b(EUCOMM)Hmgu}/Zranb1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Zranb1^{tm1b(EUCOMM)Hmgu}/Ics	preweaning lethality, incomplete penetrance	J:211773
Zranb1^{tm1c(EUCOMM)Hmgu}/Zranb1^{tm1c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2	normal immune system phenotype	J:235701
Zranb1^{tm1c(EUCOMM)Hmgu}/Zranb1^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0 involves: 129S4/SvJaeSor * C57BL/6N * CBA	abnormal dendritic cell physiology	J:235701
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:235701
	decreased T helper 1 cell number	J:235701
	decreased T-helper 17 cell number	J:235701
	normal immune system phenotype	J:235701
Zranb1^{tm1d(EUCOMM)Hmgu}/Zranb1^{tm1d(EUCOMM)Hmgu} involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N	decreased CD4-positive, alpha-beta T cell number	J:235701
	decreased circulating interferon-gamma level	J:235701
	decreased circulating interleukin-17 level	J:235701
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:235701
	decreased T helper 1 cell number	J:235701
	decreased T-helper 17 cell number	J:235701
	normal immune system phenotype	J:235701

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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