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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rfx2
regulatory factor X, 2 (influences HLA class II expression)
MGI:106583
30 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rfx2Gt(IST10638H11)Tigm/Rfx2Gt(IST10638H11)Tigm
either: C57BL/6N-Rfx2Gt(IST10638H11)Tigm or (involves: C57BL/6N * CD-1) 		abnormal spermatid morphology J:227136
abnormal spermatogenesis J:227136
abnormal spermiogenesis J:227136
normal behavior/neurological phenotype J:227136
normal embryo phenotype J:227136
increased Leydig cell number J:227136
Leydig cell hypertrophy J:227136
male infertility J:227136
multinucleated giant male germ cells J:227136
Rfx2tm1.1Wrth/Rfx2tm1.1Wrth
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal acrosome assembly J:228765
abnormal acrosome morphology J:228765
abnormal cauda epididymis morphology J:228765
abnormal ectoplasmic specialization morphology J:228765
abnormal Golgi apparatus morphology J:228765
abnormal sperm axoneme morphology J:228765
arrest of spermiogenesis J:228765
normal cellular phenotype J:228765
detached acrosome J:228765
ectopic manchette J:228765
normal embryo phenotype J:228765
male infertility J:228765
multinucleated giant male germ cells J:228765
normal reproductive system phenotype J:228765
small testis J:228765
Rfx2tm1.2Wrth/Rfx2tm1.2Wrth
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal acrosome assembly J:228765
abnormal acrosome morphology J:228765
abnormal cauda epididymis morphology J:228765
abnormal ectoplasmic specialization morphology J:228765
abnormal Golgi apparatus morphology J:228765
abnormal sperm axoneme morphology J:228765
arrest of spermiogenesis J:228765
normal cellular phenotype J:228765
detached acrosome J:228765
ectopic manchette J:228765
normal embryo phenotype J:228765
male infertility J:228765
multinucleated giant male germ cells J:228765
normal reproductive system phenotype J:228765
small testis J:228765
Rfx2tm1Hncs/Rfx2tm1Hncs
involves: 129S6/SvEvTac * C57BL/6 		abnormal acrosome morphology J:230575
abnormal epididymis morphology J:230575
abnormal manchette morphology J:230575
abnormal sperm axoneme morphology J:230575
abnormal spermatid morphology J:230575
abnormal spermatogenesis J:230575
arrest of spermatogenesis J:230575
arrest of spermiogenesis J:230575
azoospermia J:230575
decreased body size J:230575
normal growth/size/body region phenotype J:230575
increased male germ cell apoptosis J:230575
male infertility J:230575
multinucleated giant male germ cells J:230575
postnatal growth retardation J:230575
premature death J:230575
normal reproductive system phenotype J:230575
small testis J:230575
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory