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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Srf
serum response factor
MGI:106658
67 phenotypes from 6 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Srftm1Nor/Srftm1Nor
involves: 129P2/OlaHsd 		abnormal gastrulation J:50876
absent mesoderm J:50876
decreased embryo size J:50876
embryonic growth retardation J:50876
embryonic lethality during organogenesis, complete penetrance J:50876
failure of primitive streak formation J:50876
Srftm1Rjs/Srftm1Rjs
involves: 129S7/SvEvBrd * C57BL/6 		abnormal gastrulation J:101311
embryonic lethality, complete penetrance J:101311
Srftm1Rjs/Srftm2.1Nor
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal fetal atrioventricular canal morphology J:101311
abnormal heart ventricle morphology J:101311
abnormal interventricular groove morphology J:101311
abnormal interventricular septum morphology J:101311
abnormal myocardium layer morphology J:101311
abnormal pericardium morphology J:101311
distended pericardium J:101311
embryonic growth arrest J:101311
embryonic lethality during organogenesis, complete penetrance J:101311
increased cardiomyocyte apoptosis J:101311
irregular heartbeat J:101311
pericardial effusion J:101311
Srftm1Rmn/Srftm1Rmn
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		absent thyroid gland J:144862
athymia J:144862
normal craniofacial phenotype J:144862
embryonic lethality, complete penetrance J:144862
normal hearing/vestibular/ear phenotype J:144862
mandible hypoplasia J:144862
persistent truncus arteriosus J:144862
ventricular septal defect J:144862
Srftm1Rmn/Srftm1Rmn
Tg(Tagln-cre)1Jomm/0
involves: CD-1 		abnormal myocardial fiber morphology J:94725
embryonic lethality during organogenesis, complete penetrance J:94725
vascular smooth muscle hypotrophy J:94725
Srftm1Zli/Srftm1Zli
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:91025
Srftm1Zli/Srftm1Zli
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129 * C57BL/6J * FVB/N 		abnormal cardiac muscle relaxation J:135043
abnormal intercalated disk morphology J:135043
abnormal myocardial fiber morphology J:135043
abnormal myocardium layer morphology J:135043
abnormal Z line morphology J:135043
cardiac fibrosis J:135043
cardiac hypertrophy J:135043
congestive heart failure J:135043
decreased heart left ventricle muscle contractility J:135043
dilated cardiomyopathy J:135043
dilated heart ventricle J:135043
increased heart left ventricle size J:135043
premature death J:135043
Srftm1Zli/Srftm1Zli
Tg(Myh7-cre)1Zli/0
involves: 129/Sv * C57BL/6 		abnormal apoptosis J:91025
abnormal heart shape J:91025
abnormal myocardial fiber morphology J:91025
disorganized myocardium J:91025
embryonic growth retardation J:91025
embryonic lethality, complete penetrance J:91025
internal hemorrhage J:91025
thin interventricular septum J:91025
thin myocardium J:91025
trabecula carnea hypoplasia J:91025
Srftm2.1Nor/Srftm2.1Nor
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal skeletal muscle fiber morphology J:96122
lethargy J:96122
postnatal growth retardation J:96122
postnatal lethality, complete penetrance J:96122
Srftm2.1Nor/Srftm2.1Nor
Tg(Myog-cre)1Eno/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal diaphragm morphology J:96122
abnormal skeletal muscle fiber morphology J:96122
normal cardiovascular system phenotype J:96122
cyanosis J:96122
decreased birth weight J:96122
decreased skeletal muscle mass J:96122
kyphosis J:96122
neonatal lethality, complete penetrance J:96122
no spontaneous movement J:96122
respiratory failure J:96122
Srftm2Nor/Srftm2Nor
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:75123
Srftm2Nor/Srftm2Nor
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd 		abnormal mature B cell morphology J:124767
absent marginal zone B cells J:124767
decreased B cell number J:124767
decreased B-1 B cell number J:124767
Srftm2Nor/Srftm2Nor
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:124767
decreased CD8-positive, alpha-beta T cell number J:124767
decreased T cell number J:124767
decreased thymocyte number J:124767
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory