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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
MGI:106677
60 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir
Slc6a4tm1(cre)Xz/Slc6a4+
involves: 129S1/Sv * C57BL/6J 		abnormal catecholamine level J:197966
abnormal emotion/affect behavior J:197966
decreased anxiety-related response J:197966
decreased locomotor activity J:197966
decreased serotonin level J:197966
normal nervous system phenotype J:197966
postnatal lethality, incomplete penetrance J:197966
Slc18a2tm1Edw/Slc18a2+
involves: 129X1/SvJ * C57BL/6 		abnormal noradrenaline level J:45183
abnormal serotonin level J:45183
decreased dopamine level J:45183
Slc18a2tm1Edw/Slc18a2tm1Edw
involves: 129X1/SvJ 		abnormal dopaminergic neuron morphology J:96932
abnormal neurotransmitter secretion J:96932
abnormal synaptic vesicle morphology J:96932
decreased dopamine level J:96932
Slc18a2tm1Edw/Slc18a2tm1Edw
involves: 129X1/SvJ * C57BL/6 		abnormal neurotransmitter secretion J:45183
abnormal noradrenaline level J:45183
abnormal serotonin level J:45183
absent gastric milk in neonates J:45183
bradykinesia J:45183
decreased body size J:45183
decreased body weight J:45183
decreased dopamine level J:45183
postnatal lethality, complete penetrance J:45183
Slc18a2tm1Kmo/Slc18a2tm1Kmo
involves: 129P2/OlaHsd * C57BL/6 		neonatal lethality, complete penetrance J:70606
Slc18a2tm1Mca/Slc18a2+
B6.129X1-Slc18a2tm1Mca 		abnormal associative learning J:125273
abnormal corticosterone level J:125273
abnormal liquid preference J:125273
normal behavior/neurological phenotype J:125273
decreased coping response J:125273
decreased locomotor activity J:125273
decreased vertical activity J:125273
enhanced long-term potentiation J:89778
Slc18a2tm1Mca/Slc18a2+
involves: 129X1/SvJ 		abnormal neurotransmitter secretion J:45184
abnormal neurotransmitter uptake J:45184
decreased dopamine level J:45184
decreased physiological sensitivity to xenobiotic J:45184
enhanced behavioral response to addictive substance J:45184
impaired behavioral response to cocaine J:45184
Slc18a2tm1Mca/Slc18a2+
involves: 129X1/SvJ * C57BL/6J 		abnormal liquid preference J:124481
normal behavior/neurological phenotype J:124481
decreased alcohol consumption J:124481
impaired conditioned place preference behavior J:124481
Slc18a2tm1Mca/Slc18a2tm1Mca
involves: 129X1/SvJ 		abnormal dopamine level J:45184
abnormal enzyme/coenzyme activity J:45184
abnormal synaptic neurotransmitter level J:45184
decreased birth body size J:45184
decreased body temperature J:45184
decreased locomotor activity J:45184
postnatal growth retardation J:45184
postnatal lethality, complete penetrance J:45184
Slc18a2tm1Uhl/Slc18a2+
involves: 129S7/SvEvBrd * C57BL/6J 		enhanced behavioral response to addictive substance J:42811
impaired conditioned place preference behavior J:42811
increased susceptibility to dopaminergic neuron neurotoxicity J:42811
premature death J:42811, J:57671
prolonged QT interval J:57671
Slc18a2tm1Uhl/Slc18a2tm1Uhl
involves: 129S7/SvEvBrd * C57BL/6J 		neonatal lethality, incomplete penetrance J:42811
postnatal lethality, complete penetrance J:42811
Slc18a2tm2Kmo/Slc18a2tm2Kmo
involves: 129P2/OlaHsd * C57BL/6 		abnormal circadian behavior J:150414
abnormal emotion/affect behavior J:150414
abnormal motor capabilities/coordination/movement J:150414
abnormal nervous system physiology J:150414
abnormal noradrenaline level J:70606, J:150414
abnormal response to new environment J:70606
abnormal response to novel odor J:150414
abnormal response to novelty J:150414
abnormal sleep pattern J:150414
alpha-synuclein inclusion body J:123245
decreased body weight J:70606
decreased coping response J:150414
decreased dopamine level J:70606, J:123245, J:150414
decreased dopaminergic neuron number J:123245
decreased locomotor activity J:123245, J:150414
decreased serotonin level J:70606, J:150414
impaired coordination J:70606
impaired gastric peristalsis J:150414
impaired olfaction J:150414
increased anxiety-related response J:150414
increased defecation amount J:150414
increased susceptibility to dopaminergic neuron neurotoxicity J:70606
normal muscle phenotype J:150414
neuron degeneration J:123245
stereotypic behavior J:70606
normal vision/eye phenotype J:150414
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12/17/2024
MGI 6.24 		The Jackson Laboratory