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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pon3
paraoxonase 3
MGI:106686
41 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pon3tm1b(KOMP)Wtsi/Pon3tm1b(KOMP)Wtsi
C57BL/6N-Pon3tm1b(KOMP)Wtsi/Kmpc 		increased circulating triglyceride level J:211773
Pon3tm1Dmsh/Pon3tm1Dmsh
B6J.129X1-Pon3tm1Dmsh 		abnormal bile composition J:234615
abnormal bile salt homeostasis J:234615
abnormal lipid level J:234615
abnormal mitochondrial ATP synthesis coupled electron transport J:234615
abnormal protein level J:234615
decreased bile salt level J:234615
decreased circulating free fatty acids level J:234615
decreased circulating HDL cholesterol level J:234615
decreased circulating triglyceride level J:234615
decreased fatty acid oxidation J:234615
decreased liver triglyceride level J:234615
decreased oxygen consumption J:234615
gallstones J:234615
increased bile salt level J:234615
increased body weight J:234615
increased circulating alanine transaminase level J:234615
increased circulating aspartate transaminase level J:234615
increased circulating bilirubin level J:234615
increased circulating cholesterol level J:234615
increased circulating LDL cholesterol level J:234615
increased circulating triglyceride level J:234615
increased gonadal fat pad weight J:234615
increased hepatocyte apoptosis J:234615
increased liver cholesterol level J:234615
increased retroperitoneal fat pad weight J:234615
increased subcutaneous adipose tissue amount J:234615
increased susceptibility to atherosclerosis J:234615
increased susceptibility to diet-induced obesity J:234615
increased susceptibility to induced morbidity/mortality J:234615
increased white fat cell lipid droplet size J:234615
increased white fat cell size J:234615
jaundice J:234615
liver inflammation J:234615
normal mortality/aging J:234615
oxidative stress J:234615
Pon3tm1Lus/Pon3tm1Lus
involves: 129X1/SvJ 		decreased glutathione level J:204799
oxidative stress J:204799
Pon3tm1Tigm/Pon3+
Not Specified 		decreased fetal weight J:184656
decreased placenta weight J:184656
Pon3tm1Tigm/Pon3tm1Tigm
Not Specified 		embryonic lethality during organogenesis, incomplete penetrance J:184656
lethality throughout fetal growth and development, incomplete penetrance J:184656
postnatal lethality, incomplete penetrance J:184656
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory