Hif1a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hif1a
hypoxia inducible factor 1, alpha subunit
MGI:106918

42 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Egln1^tm1.1Brei/Egln1^tm1.1Brei Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(CD68-icre)1Bwlx/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	domed cranium	J:194598
	normal hematopoietic system phenotype	J:194598
	hydrocephaly	J:194598
	increased hematocrit	J:194598
	postnatal lethality	J:194598
Egln1^tm1.1Fsl/Egln1⁺ Hif1a^tm3.1Rsjo/Hif1a⁺ B6.Cg-Egln1^tm1.1Fsl Hif1a^tm3.1Rsjo	increased hematocrit	J:202737
Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Hif1a^tm3Rsjo/Hif1a^tm3Rsjo B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Hif1a^tm3Rsjo	extramedullary hematopoiesis	J:202737
	increased erythropoietin level	J:202737
	increased hematocrit	J:202737
	increased spleen weight	J:202737
	premature death	J:202737
Egln2^tm1Pec/Egln2^tm1Pec Hif1a^tm1Pec/Hif1a⁺ involves: 129S/SvEv * Swiss	normal muscle phenotype	J:132630
Egln3^tm1Pjr/Egln3^tm1Pjr Hif1a^tm1Pec/Hif1a⁺ involves: 129S/SvEv * Swiss	abnormal neuron physiology	J:136034
	abnormal superior cervical ganglion morphology	J:136034
Epas1^tm1Mcs/Epas1^tm1Mcs Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S1/Sv * 129X1/SvJ * CD-1	decreased erythroid progenitor cell number	J:186085
	decreased trabecular bone volume	J:186085
	normal hematopoietic system phenotype	J:186085
Epas1^tm1Mcs/Epas1^tm1Mcs Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Vhl^tm1Jae/Vhl^tm1Jae Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1	decreased bone trabecula number	J:186085
	decreased circulating erythropoietin level	J:186085
	decreased trabecular bone volume	J:186085
	normal hematopoietic system phenotype	J:186085
Gt(ROSA)26Sor^tm1(rtTA)Awu/Gt(ROSA)26Sor⁺ Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(tetO-cre)LC1Bjd/0 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * 129X1/SvJ	abnormal cell migration	J:130751
Hif1a^tm1.1Mcs/Hif1a⁺ involves: 129S6/SvEvTac	abnormal embryo development	J:105812
	hemorrhage	J:105812
	pericardial effusion	J:105812
	prenatal lethality, incomplete penetrance	J:105812
Hif1a^tm1.1Mcs/Hif1a^tm1.1Mcs involves: 129S6/SvEvTac	abnormal developmental patterning	J:105812
	abnormal embryo development	J:105812
	abnormal embryonic epiblast morphology	J:105812
	embryonic growth arrest	J:105812
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:105812
Hif1a^tm1Rsjo/Hif1a^tm1Rsjo Hif1an^tm1.2Rsjo/Hif1an^tm1.2Rsjo involves: 129S1/Sv * 129X1/SvJ	normal cellular phenotype	J:160941
	decreased cell proliferation	J:160941
Hif1a^tm1Rsjo/Hif1a^tm1Rsjo Hif1an^tm1.2Rsjo/Hif1an^tm1.2Rsjo Vhl^tm1Jae/Vhl^tm1Jae involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	normal cellular phenotype	J:160941
Hif1a^tm2Mcs/Hif1a^tm2Mcs Not Specified	no abnormal phenotype detected	J:105812
Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Pck1-cre)Vhh}/Y involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	abnormal cell differentiation	J:130751
	decreased susceptibility to injury	J:130751
	kidney inflammation	J:130751
	renal fibrosis	J:130751
Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae involves: 129 * BALB/c * C57BL/6	abnormal kidney morphology	J:106705
	abnormal kidney vasculature morphology	J:106705
	abnormal vasodilation	J:97652
	hepatic steatosis	J:97652
	increased hemoglobin content	J:97652
	increased hepatic hemangioma incidence	J:97652
	increased vascular endothelial cell number	J:97652
	kidney cyst	J:106705
	kidney inflammation	J:106705
	polycythemia	J:97652
Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Vhl^tm1Jae/Vhl^tm1Jae Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129 * BALB/c * C57BL/6 * DBA	abnormal vasodilation	J:97652
	hepatic steatosis	J:97652
	increased vascular endothelial cell number	J:97652
Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Vhl^tm1Jae/Vhl^tm1Jae Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1	increased circulating erythropoietin level	J:186085
	increased hematocrit	J:186085

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