Mttp Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mttp
microsomal triglyceride transfer protein
MGI:106926

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mttp^tm1Chan/Mttp^tm1Chan involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal circulating cholesterol level	J:53390
	abnormal triglyceride level	J:53390
	decreased circulating HDL cholesterol level	J:53390
	decreased circulating LDL cholesterol level	J:53390
	decreased circulating VLDL cholesterol level	J:53390
	decreased circulating VLDL triglyceride level	J:53390
Mttp^tm1Sgy/Mttp⁺ involves: 129S4/SvJae	abnormal circulating cholesterol level	J:48934
	abnormal circulating lipid level	J:48934
	abnormal lipid homeostasis	J:48934
	abnormal lipid level	J:48934
	abnormal visceral yolk sac endoderm morphology	J:48934
	decreased circulating cholesterol level	J:48934
	decreased circulating LDL cholesterol level	J:48934
	decreased circulating VLDL cholesterol level	J:48934
	hepatic steatosis	J:48934
	increased liver cholesterol level	J:48934
	increased liver triglyceride level	J:48934
Mttp^tm1Sgy/Mttp^tm1Sgy involves: 129S4/SvJae	abnormal lipid homeostasis	J:48934
	abnormal visceral yolk sac blood island morphology	J:48934
	abnormal visceral yolk sac endoderm morphology	J:48934
	decreased erythrocyte cell number	J:48934
	embryo tissue necrosis	J:48934
	embryonic growth retardation	J:48934
	embryonic lethality during organogenesis, incomplete penetrance	J:48934
	exencephaly	J:48934
	hemorrhage	J:48934
	incomplete rostral neuropore closure	J:48934
	pale yolk sac	J:48934
Mttp^tm2Sgy/Mttp^tm2Sgy Tg(Mx1-cre)1Cgn/Tg(Mx1-cre)1Cgn involves: 129S4/SvJae * C57BL/6 * CBA	abnormal circulating protein level	J:83459
	abnormal liver physiology	J:83459
	decreased circulating cholesterol level	J:83459
	decreased circulating HDL cholesterol level	J:83459
	decreased circulating LDL cholesterol level	J:83459
	decreased circulating triglyceride level	J:83459
	decreased circulating VLDL cholesterol level	J:83459
	increased liver cholesterol level	J:83459
	increased liver triglyceride level	J:83459
	increased liver weight	J:83459

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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