Ppp3cb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppp3cb
protein phosphatase 3, catalytic subunit, beta isoform
MGI:107163

38 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppp3cb^{em1(IMPC)Ccpcz}/Ppp3cb^{em1(IMPC)Ccpcz} C57BL/6NCrl-Ppp3cb^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart left ventricle morphology	J:211773
	abnormal kidney morphology	J:211773
	decreased CD4-positive NK T cell number	J:211773
	decreased CD4-positive, alpha-beta T cell number	J:211773
	decreased CD8-positive, alpha-beta T cell number	J:211773
	decreased memory-marker CD4-positive NK T cell number	J:211773
	decreased NK T cell number	J:211773
	decreased T-helper cell number	J:211773
	immune system phenotype	J:211773
	increased effector memory CD8-positive, alpha-beta T cell number	J:211773
	increased effector memory T-helper cell number	J:211773
Ppp3cb^M1Btlr/Ppp3cb⁺ C57BL/6J-Ppp3cb^M1Btlr	abnormal CD4-positive, alpha-beta T cell physiology	J:236670
	abnormal CD8-positive, alpha-beta T cell physiology	J:236670
	abnormal NK cell physiology	J:236670
	increased CD8-positive, alpha-beta memory T cell proliferation	J:236670
Ppp3cb^M1Btlr/Ppp3cb^M1Btlr C57BL/6J-Ppp3cb^M1Btlr	abnormal CD4-positive, alpha-beta T cell physiology	J:236670
	abnormal CD8-positive, alpha-beta T cell physiology	J:236670
	abnormal NK cell physiology	J:236670
	increased CD8-positive, alpha-beta memory T cell proliferation	J:236670
Ppp3cb^m2Btlr/Ppp3cb⁺ C57BL/6J-Ppp3cb^m2Btlr	abnormal CD4-positive, alpha-beta T cell physiology	J:236671
	abnormal CD8-positive, alpha-beta T cell physiology	J:236671
	increased CD8-positive, alpha-beta memory T cell proliferation	J:236671
Ppp3cb^m2Btlr/Ppp3cb^m2Btlr C57BL/6J-Ppp3cb^m2Btlr	abnormal CD4-positive, alpha-beta T cell physiology	J:236671
	abnormal CD8-positive, alpha-beta T cell physiology	J:236671
	abnormal NK cell physiology	J:236671
	decreased response to antigen	J:236671
	increased CD8-positive, alpha-beta memory T cell proliferation	J:236671
Ppp3cb^M3Btlr/Ppp3cb⁺ C57BL/6J-Ppp3cb^M3Btlr	decreased CD8-positive, alpha-beta memory T cell number	J:254889
Ppp3cb^M3Btlr/Ppp3cb⁺ C57BL/6J-Ppp3cb^M3Btlr	increased central memory CD4-positive, alpha-beta T cell number	J:254889
Ppp3cb^M3Btlr/Ppp3cb^M3Btlr C57BL/6J-Ppp3cb^M3Btlr	decreased CD8-positive, alpha-beta memory T cell number	J:254889
	decreased CD8-positive, naive alpha-beta T cell number	J:254889
	increased central memory CD4-positive, alpha-beta T cell number	J:254889
	increased central memory CD8 positive, alpha-beta T cell number	J:254889
Ppp3cb^M4Btlr/Ppp3cb⁺ C57BL/6J-Ppp3cb^M4Btlr	decreased CD8-positive, alpha-beta memory T cell number	J:254905
Ppp3cb^M4Btlr/Ppp3cb⁺ C57BL/6J-Ppp3cb^M4Btlr	increased central memory CD8 positive, alpha-beta T cell number	J:254905
Ppp3cb^M4Btlr/Ppp3cb^M4Btlr C57BL/6J-Ppp3cb^M4Btlr	decreased CD8-positive, alpha-beta memory T cell number	J:254905
Ppp3cb^M4Btlr/Ppp3cb^M4Btlr C57BL/6J-Ppp3cb^M4Btlr	increased central memory CD8 positive, alpha-beta T cell number	J:254905
Ppp3cb^m5Btlr/Ppp3cb^m5Btlr C57BL/6J-Ppp3cb^m5Btlr	abnormal T cell morphology	J:272839
Ppp3cb^m5Btlr/Ppp3cb^m5Btlr C57BL/6J-Ppp3cb^m5Btlr	decreased CD8-positive, alpha-beta T cell number	J:272839
Ppp3cb^M6Btlr/Ppp3cb^M6Btlr C57BL/6J-Ppp3cb^M6Btlr	abnormal lymphocyte morphology	J:272840
	decreased alpha-beta T cell number	J:272840
	decreased CD4-positive, alpha-beta T cell number	J:272840
	decreased CD8-positive, alpha-beta T cell number	J:272840
Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk involves: 129S6/SvEvTac	abnormal cytokine secretion	J:109586
	abnormal skeletal muscle fiber type ratio	J:110822
	decreased body weight	J:110822
	decreased skeletal muscle fiber diameter	J:110822
	decreased susceptibility to injury	J:109586
	decreased T cell proliferation	J:109586
	increased skeletal muscle fiber number	J:110822
Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk involves: 129S6/SvEvTac * C57BL/6	abnormal T cell differentiation	J:77729
	normal cardiovascular system phenotype	J:75775
	decreased body weight	J:75775
	decreased response of heart to induced stress	J:75775
	decreased single-positive T cell number	J:77729
	decreased T cell number	J:77729
	decreased T cell proliferation	J:77729
	decreased thymus weight	J:75775
	small heart	J:75775
	thymus hypoplasia	J:77729

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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