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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
MGI:107164
25 phenotypes from 2 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ppp3catm1Jse/Ppp3ca+
involves: 129S4/SvJae 		abnormal urine osmolality J:110350
Ppp3catm1Jse/Ppp3catm1Jse
either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6) 		decreased interferon-gamma secretion J:71750
decreased interleukin-2 secretion J:71750
decreased interleukin-4 secretion J:71750
decreased T cell proliferation J:71750
Ppp3catm1Jse/Ppp3catm1Jse
involves: 129S4/SvJae 		abnormal skeletal muscle fiber type ratio J:110822
decreased body weight J:110350, J:110822
decreased circulating calcium level J:110350
decreased circulating glucose level J:110350
decreased skeletal muscle fiber number J:110822
decreased urine creatinine level J:110350
decreased urine osmolality J:110350
increased blood urea nitrogen level J:110350
increased circulating creatinine level J:110350
increased skeletal muscle fiber diameter J:110822
premature death J:110350
Ppp3catm1Jse/Ppp3catm1Jse
involves: 129S4/SvJae * Black Swiss 		abnormal hippocampal mossy fiber morphology J:39103
Tg(Myh6-Ppp3ca)37Eno/0
involves: C57BL/6 * FVB 		cardiac hypertrophy J:227485
premature death J:227485
Tg(Myh6-Ppp3ca)37Eno/0
involves: FVB 		cardiac hypertrophy J:93176, J:94665, J:213308
cardiac interstitial fibrosis J:93176
dilated heart left ventricle J:93176
dilated heart right ventricle J:93176
increased heart weight J:109586, J:213308
increased myocardial fiber size J:94665
myocardial fiber disarray J:93176
premature death J:93176
pulmonary edema J:93176
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory