Aurkb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aurkb
aurora kinase B
MGI:107168

28 phenotypes from 5 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aurkb^tm1.1Mama/Aurkb^tm1.1Mama involves: 129/Sv * C57BL/6 * CD-1 * SJL	abnormal cell morphology	J:173575
	abnormal cell nucleus morphology	J:173575
	abnormal mitosis	J:173575
	abnormal mitotic spindle morphology	J:173575
	increased cell nucleus count	J:173575
	increased fibroblast apoptosis	J:173575
	polyploidy	J:173575
Aurkb^tm1.2Mama/Aurkb⁺ involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	increased adenocarcinoma incidence	J:173575
	increased liver adenocarcinoma incidence	J:173575
	increased skin papilloma incidence	J:173575
	increased tumor incidence	J:173575
	oligozoospermia	J:173575
	premature death	J:173575
Aurkb^tm1.2Mama/Aurkb^tm2.2Mama involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	abnormal ectoplacental cone morphology	J:173575
	abnormal embryonic tissue morphology	J:173575
	abnormal inner cell mass morphology	J:173575
	abnormal mitosis	J:173575
	abnormal mitotic spindle morphology	J:173575
	abnormal trophoblast giant cell morphology	J:173575
	decreased embryo size	J:173575
	decreased trophoblast giant cell number	J:173575
	edema	J:173575
	embryonic lethality	J:173575
	hemorrhage	J:173575
	increased embryonic tissue cell apoptosis	J:173575
	polyploidy	J:173575
Tg(B4galt1-Aurkb)1Saco/0 involves: 129/Sv * C57BL/6J * SJL	no abnormal phenotype detected	J:142947
Tg(B4galt1-AurkbK111RL323I)1Saco/0 involves: 129/Sv * C57BL/6J * SJL	abnormal male meiosis	J:142947
	abnormal spermatid morphology	J:142947
	abnormal spermatogenesis	J:142947
	oligozoospermia	J:142947
	reduced male fertility	J:142947

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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