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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
MGI:107170
62 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 		enlarged spleen J:201448
expanded mesangial matrix J:201448
glomerulonephritis J:201448
increased anti-double stranded DNA antibody level J:201448
increased autoantibody level J:201448
increased B cell number J:201448
increased germinal center B cell number J:201448
spleen hyperplasia J:201448
Ptpn22tm1.1Draw/Ptpn22+
involves: 129 * C57BL/6 		abnormal B cell differentiation J:201448
abnormal B cell morphology J:201448
abnormal B cell number J:201448
abnormal B cell physiology J:201448
abnormal T cell morphology J:201448
abnormal T cell number J:201448
abnormal T cell physiology J:201448
abnormal thymus morphology J:201448
autoimmune response J:201448
decreased B cell apoptosis J:201448
decreased follicular B cell number J:201448
decreased mature B cell number J:201448
enlarged spleen J:201448
increased anti-double stranded DNA antibody level J:201448
increased B cell number J:201448
increased B cell proliferation J:201448
increased CD4-positive, alpha-beta memory T cell number J:201448
increased double-positive T cell number J:201448
increased germinal center B cell number J:201448
increased IgG1 level J:201448
increased interleukin-2 secretion J:201448
increased regulatory T cell number J:201448
increased spleen germinal center size J:201448
increased T cell proliferation J:201448
increased transitional stage T1 B cell number J:201448
spleen hyperplasia J:201448
thymus hyperplasia J:201448
Ptpn22tm1.1Draw/Ptpn22tm1.1Draw
involves: 129 * C57BL/6 		abnormal B cell activation J:201448
abnormal B cell differentiation J:201448
abnormal B cell morphology J:201448
abnormal B cell physiology J:201448
abnormal lung morphology J:201448
abnormal salivary gland morphology J:201448
abnormal T cell differentiation J:201448
abnormal T cell morphology J:201448
abnormal T cell physiology J:201448
abnormal thymus morphology J:201448
autoimmune response J:201448
decreased B cell apoptosis J:201448
decreased follicular B cell number J:201448
decreased mature B cell number J:201448
enlarged spleen J:201448
glomerulonephritis J:201448
normal immune system phenotype J:201448
increased anti-double stranded DNA antibody level J:201448
increased anti-insulin autoantibody level J:201448
increased B cell number J:201448
increased B cell proliferation J:201448
increased double-positive T cell number J:201448
increased effector memory CD4-positive, alpha-beta T cell number J:201448
increased effector memory CD8-positive, alpha-beta T cell number J:201448
increased germinal center B cell number J:201448
increased IgE level J:201448
increased IgG1 level J:201448
increased IgG3 level J:201448
increased IgM level J:201448
increased inflammatory response J:201448
increased interleukin-2 secretion J:201448
increased physiological sensitivity to xenobiotic J:201448
increased regulatory T cell number J:201448
increased spleen germinal center size J:201448
increased T cell proliferation J:201448
increased transitional stage T1 B cell number J:201448
premature death J:201448
spleen hyperplasia J:201448
thymus hyperplasia J:201448
vascular inflammation J:201448
Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
involves: C57BL/6 		abnormal dendritic cell physiology J:176519
enlarged spleen J:176519
enlarged thymus J:176519
normal immune system phenotype J:176519
increased B cell proliferation J:176519
increased CD4-positive, alpha-beta T cell number J:176519
increased CD8-positive, alpha-beta T cell number J:176519
increased dendritic cell number J:176519
increased IgG2a level J:176519
increased IgG3 level J:176519
increased IgM level J:176519
increased interleukin-12 secretion J:176519
increased spleen germinal center number J:176519
increased spleen germinal center size J:176519
increased T cell number J:176519
increased T cell proliferation J:176519
Ptpn22tm1Achn/Ptpn22tm1Achn
involves: C57BL/6 		abnormal Peyer's patch germinal center morphology J:90029
abnormal T cell physiology J:90029
enlarged lymph nodes J:90029
enlarged spleen J:90029
increased B cell number J:90029
increased follicular B cell number J:90029
increased IgE level J:90029
increased IgG1 level J:90029
increased IgG2a level J:90029
increased spleen germinal center number J:90029
Ptpn22tm2Achn/Ptpn22tm2Achn
B6.Cg-Ptpn22tm2Achn 		abnormal double-positive T cell morphology J:147129
abnormal T cell activation J:147129
abnormal T cell subpopulation ratio J:147129
abnormal thymocyte activation J:147129
enlarged lymph nodes J:147129
increased memory T cell number J:147129
Ptpn22tm2Achn/Ptpn22tm2Achn
involves: C57BL/6 		abnormal Peyer's patch germinal center morphology J:90029
abnormal T cell physiology J:90029
enlarged lymph nodes J:90029
enlarged spleen J:90029
increased B cell number J:90029
increased follicular B cell number J:90029
increased IgE level J:90029
increased IgG1 level J:90029
increased IgG2a level J:90029
increased spleen germinal center number J:90029
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory