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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
MGI:107170
24 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J 		normal immune system phenotype J:176519
Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6 		increased CD4-positive, alpha-beta T cell number J:176519
increased T cell proliferation J:176519
Ptpn22tm2Achn/Ptpn22tm2Achn
Ptprctm1Weis/Ptprctm1Weis
B6.Cg-Ptprctm1Weis Ptpn22tm2Achn 		abnormal B cell activation J:147129
abnormal double-positive T cell morphology J:147129
abnormal follicular B cell physiology J:147129
abnormal lymphocyte cell number J:147129
abnormal T cell activation J:147129
abnormal T cell subpopulation ratio J:147129
abnormal thymocyte activation J:147129
decreased body weight J:147129
decreased follicular B cell number J:147129
enlarged lymph nodes J:147129
glomerulonephritis J:147129
glomerulosclerosis J:147129
increased autoantibody level J:147129
increased memory T cell number J:147129
increased plasma cell number J:147129
increased transitional stage B cell number J:147129
increased urine protein level J:147129
liver inflammation J:147129
lung inflammation J:147129
pale kidney J:147129
premature death J:147129
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory