Ptpn22 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
MGI:107170

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: C57BL/6 * C57BL/6J * DBA/2J	normal immune system phenotype	J:176519
Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas Tg(TcraTcrb)425Cbn/0 involves: BALB/c * C57BL/6	increased CD4-positive, alpha-beta T cell number	J:176519
	increased T cell proliferation	J:176519
Ptpn22^tm2Achn/Ptpn22^tm2Achn Ptprc^tm1Weis/Ptprc^tm1Weis B6.Cg-Ptprc^tm1Weis Ptpn22^tm2Achn	abnormal B cell activation	J:147129
	abnormal double-positive T cell morphology	J:147129
	abnormal follicular B cell physiology	J:147129
	abnormal lymphocyte cell number	J:147129
	abnormal T cell activation	J:147129
	abnormal T cell subpopulation ratio	J:147129
	abnormal thymocyte activation	J:147129
	decreased body weight	J:147129
	decreased follicular B cell number	J:147129
	enlarged lymph nodes	J:147129
	glomerulonephritis	J:147129
	glomerulosclerosis	J:147129
	increased autoantibody level	J:147129
	increased memory T cell number	J:147129
	increased plasma cell number	J:147129
	increased transitional stage B cell number	J:147129
	increased urine protein level	J:147129
	liver inflammation	J:147129
	lung inflammation	J:147129
	pale kidney	J:147129
	premature death	J:147129

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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