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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fosl1
fos-like antigen 1
MGI:107179
62 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+
Tg(Cebpb-tTA)5Bjd/0
involves: 129S4/SvJae * C57BL/6 * NMRI 		abnormal liver morphology J:210545
decreased circulating alanine transaminase level J:210545, J:213764
decreased circulating cholesterol level J:213764
decreased circulating interleukin-6 level J:210545
decreased liver triglyceride level J:210545
decreased liver weight J:210545
decreased susceptibility to diet-induced hepatic steatosis J:210545
decreased susceptibility to injury J:213764
impaired glucose tolerance J:210545
increased bile salt level J:213764
increased circulating cholesterol level J:210545
increased circulating triglyceride level J:210545
increased liver weight J:213764
insulin resistance J:210545
liver inflammation J:210545
normal liver/biliary system phenotype J:213764
normal mortality/aging J:213764
Fosl1tm1Wag/Fosl1tm1Wag
either: 129/Sv or (involves: 129/Sv * C57BL/6) 		abnormal chorionic plate morphology J:65292
abnormal embryonic erythrocyte morphology J:65292
abnormal parietal yolk sac morphology J:65292
abnormal placenta labyrinth morphology J:65292
abnormal placenta morphology J:65292
abnormal placenta vasculature J:65292
abnormal placental labyrinth vasculature morphology J:65292
abnormal visceral endoderm morphology J:65292
abnormal visceral yolk sac endoderm morphology J:65292
abnormal visceral yolk sac morphology J:65292
abnormal vitelline vasculature morphology J:65292
decreased embryo size J:65292
embryonic lethality during organogenesis, complete penetrance J:65292
enlarged pericardium J:65292
Fosl1tm2.1Wag/Fosl1tm2.1Wag
involves: 129P2/OlaHsd 		prenatal lethality, complete penetrance J:93053
Fosl1tm2Wag/Fosl1tm2Wag
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:93053
Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal osteoblast physiology J:93053
normal cardiovascular system phenotype J:95691
decreased bone mass J:93053
normal liver/biliary system phenotype J:213764
osteoporosis J:93053
Tg(H2-K-Fosl1)1Wag/0
involves: C57BL/6 * CBA 		abnormal bone mineralization J:64494
abnormal bone structure J:64494
abnormal cranium morphology J:64494
abnormal long bone metaphysis morphology J:64494
abnormal long bone morphology J:64494
abnormal neurocranium morphology J:64494
abnormal osteoblast physiology J:64494
abnormal rib morphology J:64494
abnormal skeleton physiology J:64494
abnormal vertebral body morphology J:64494
anemia J:64494
decreased cardiac muscle contractility J:95691
enhanced osteoblast differentiation J:64494
enlarged spleen J:64494
extramedullary hematopoiesis J:64494
increased bone mass J:64494
increased compact bone thickness J:64494
increased susceptibility to induced morbidity/mortality J:95691
increased tumor incidence J:64494
kyphosis J:64494
liver cirrhosis J:64494
osteosclerosis J:64494
postnatal growth retardation J:64494
premature death J:64494
short femur J:64494
thick neurocranium J:64494
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory