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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccr5
C-C motif chemokine receptor 5
MGI:107182
54 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccr5tm1Blck/Ccr5tm1Blck
B6.129P2-Ccr5tm1Blck 		abnormal cellular extravasation J:104744
abnormal leukocyte adhesion J:104744
abnormal response to cardiac infarction J:104744
increased length of allograft survival J:105072
Ccr5tm1Brv/Ccr5tm1Brv
either: (involves: 129S1/Sv * ICR) or (involves: 129S1/Sv * 129X1/SvJ * ICR) 		abnormal cytokine secretion J:46941
decreased interleukin-1 beta secretion J:46941
decreased interleukin-6 secretion J:46941
decreased susceptibility to endotoxin shock J:46941
increased IgG1 level J:46941
increased interferon-gamma secretion J:46941
increased interleukin-4 secretion J:46941
increased susceptibility to bacterial infection J:46941
increased susceptibility to type IV hypersensitivity reaction J:46941
Ccr5tm1Kuz/Ccr5+
involves: 129P2/OlaHsd 		normal reproductive system phenotype J:119074
Ccr5tm1Kuz/Ccr5tm1Kuz
B6.129P2-Ccr5tm1Kuz 		abnormal conditioned taste aversion behavior J:102583
normal behavior/neurological phenotype J:84037
bronchiolitis J:162707
cornea vascularization J:118018
increased alcohol consumption J:102583
increased fluid intake J:102583
increased susceptibility to Coronaviridae infection J:162707
normal mortality/aging J:84037
normal nervous system phenotype J:84037
Ccr5tm1Kuz/Ccr5tm1Kuz
B6.129P2-Ccr5tm1Kuz/J 		decreased skeletal muscle glycogen level J:264446
impaired exercise endurance J:264446
Ccr5tm1Kuz/Ccr5tm1Kuz
involves: 129P2/OlaHsd 		abnormal cardiovascular system physiology J:227458
abnormal heart size J:227458
decreased inflammatory response J:227458
decreased right ventricle systolic pressure J:227458
decreased susceptibility to injury J:227458
Ccr5tm1Kuz/Ccr5tm1Kuz
involves: 129P2/OlaHsd * C57BL/6 		abnormal astrocyte physiology J:153059
abnormal CD4-positive, alpha beta T cell morphology J:110814
abnormal CD8-positive, alpha beta T cell morphology J:110814
abnormal cytokine level J:110814
abnormal glial cell physiology J:153059
abnormal hepatocyte physiology J:100869
abnormal Ito cell morphology J:152548
abnormal Kupffer cell morphology J:152548
abnormal locomotor behavior J:110814
abnormal long-term spatial reference memory J:153059
abnormal nervous system physiology J:132342
abnormal NK T cell physiology J:100869
abnormal spatial learning J:153059
decreased microglial cell activation J:153059
decreased NK cell number J:135308
decreased susceptibility to induced colitis J:110814
decreased susceptibility to Retroviridae infection J:132342
impaired macrophage chemotaxis J:64293, J:84243, J:153059
increased NK T cell number J:110814
increased susceptibility to fungal infection J:64293
liver failure J:100869
Ccr5tm1Kuz/Ccr5tm1Kuz
Tg(CAG-EGFP)1Osb/?
involves: 129P2/OlaHsd * C3H * C57BL/6 		decreased metastatic potential J:97833
Ccr5tm1Sush/Ccr5tm1Sush
B6.129P2-Ccr5tm1Sush 		abnormal leukocyte physiology J:94937
decreased T cell proliferation J:94937
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory