About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl6
B cell leukemia/lymphoma 6
MGI:107187
77 phenotypes from 8 alleles in 13 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl6tm1.1Dent/Bcl6tm1.1Dent
involves: 129S/SvEv * C57BL/6 * FVB/N 		no abnormal phenotype detected J:202372
Bcl6tm1.1Dent/Bcl6tm1.1Dent
Tg(Cd4-cre)1Cwi/0
involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N 		abnormal T follicular helper cell differentiation J:202372
decreased germinal center B cell number J:202372
decreased IgG level J:202372
decreased interleukin-4 secretion J:202372
decreased T follicular helper cell number J:202372
increased interleukin-10 secretion J:202372
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 * C57BL/6JJcl 		abnormal humoral immune response J:190943
abnormal memory B cell morphology J:190943
abnormal memory B cell physiology J:190943
abnormal somatic hypermutation frequency J:190943
decreased germinal center B cell number J:190943
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0
involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2 		decreased germinal center B cell number J:190943
normal immune system phenotype J:190943
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl 		decreased germinal center B cell number J:190943
normal immune system phenotype J:190943
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * C57BL/6JJcl * DBA/2 		abnormal humoral immune response J:190943
abnormal somatic hypermutation frequency J:190943
absent germinal center B cells J:190943
decreased germinal center B cell number J:190943
decreased T follicular helper cell number J:190943
Bcl6tm1.1Toka/Bcl6tm1.1Toka
involves: C57BL/6 * NZB 		abnormal Peyer's patch morphology J:174014
decreased germinal center B cell number J:174014
decreased T follicular helper cell number J:174014
normal immune system phenotype J:174014
Bcl6tm1Gdba/Bcl6tm1Gdba
Tg(ACTA1-rtTA,tetO-cre)102Monk/0
involves: C3H * C57BL/6 		increased body fat mass J:271078
increased white adipose tissue amount J:271078
increased white fat cell size J:271078
Bcl6tm1Gdba/Bcl6tm1Gdba
Tg(Adipoq-cre)1Evdr/0
involves: C57BL/6 * FVB/NJ 		abnormal gonadal fat pad morphology J:271078
abnormal lipid level J:271078
decreased adipocyte glucose uptake J:271078
decreased ceramide level J:271078
decreased circulating free fatty acids level J:271078
decreased circulating insulin level J:271078
decreased circulating triglyceride level J:271078
decreased fasting circulating glucose level J:271078
decreased liver triglyceride level J:271078
decreased liver weight J:271078
decreased respiratory quotient J:271078
decreased susceptibility to diet-induced hepatic steatosis J:271078
impaired gluconeogenesis J:271078
increased adipocyte glucose uptake J:271078
increased body fat mass J:271078
increased circulating adiponectin level J:271078
increased circulating leptin level J:271078
increased insulin sensitivity J:271078
increased lipogenesis J:271078
increased skeletal muscle cell glucose uptake J:271078
increased subcutaneous adipose tissue amount J:271078
increased susceptibility to diet-induced obesity J:271078
increased white fat cell size J:271078
white adipose tissue inflammation J:271078
Bcl6tm1Htno/Bcl6+
involves: 129S1/Sv * 129X1/SvJ 		abnormal apoptosis J:82037
Bcl6tm1Htno/Bcl6tm1Htno
involves: 129S1/Sv * 129X1/SvJ 		decreased fertilization frequency J:82037
increased male germ cell apoptosis J:82037
oligozoospermia J:82037
reduced male fertility J:82037
Bcl6tm1Htno/Bcl6tm1Htno
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal spleen morphology J:55952
cardiac interstitial fibrosis J:55952
decreased body size J:55952
decreased body weight J:55952
dilated heart ventricle J:55952
lung inflammation J:55952
myocardial fiber degeneration J:55952
myocarditis J:55952
postnatal lethality, incomplete penetrance J:55952
premature death J:55952
thin ventricular wall J:55952
Bcl6tm1Rdf/Bcl6tm1Rdf
involves: 129S1/Sv 		abnormal B cell physiology J:40769
abnormal humoral immune response J:40769
abnormal immune system morphology J:40769
abnormal immune system physiology J:40769
abnormal Peyer's patch germinal center morphology J:40769
abnormal T-helper 2 physiology J:40769
absent lymph node germinal center J:40769
absent spleen germinal center J:40769
decreased IgG level J:40769
decreased IgM level J:40769
heart inflammation J:40769
increased eosinophil cell number J:40769
increased inflammatory response J:40769
increased susceptibility to bacterial infection J:40769
liver inflammation J:40769
lung inflammation J:40769
postnatal growth retardation J:40769
small thymus J:40769
spleen hyperplasia J:40769
Bcl6tm1Sdt/Bcl6tm1Sdt
involves: 129/Sv * C57BL/6 		abnormal blood cell morphology/development J:123621
abnormal chemokine level J:123621
abnormal immune system physiology J:123621
decreased bone marrow cell number J:123621
postnatal growth retardation J:123621
postnatal lethality, incomplete penetrance J:123621
spleen hypoplasia J:123621
Bcl6tm2Rdf/Bcl6tm2Rdf
involves: 129S1/Sv 		abnormal B cell physiology J:40769
abnormal humoral immune response J:40769
abnormal immune system morphology J:40769
abnormal immune system physiology J:40769
abnormal Peyer's patch germinal center morphology J:40769
abnormal T-helper 2 physiology J:40769
absent lymph node germinal center J:40769
absent spleen germinal center J:40769
decreased B cell proliferation J:40769
decreased body size J:194821
decreased IgG level J:40769
decreased IgM level J:40769
heart inflammation J:40769
increased eosinophil cell number J:40769
increased inflammatory response J:40769
increased susceptibility to bacterial infection J:40769
liver inflammation J:40769
lung inflammation J:40769
postnatal growth retardation J:40769
prenatal lethality, incomplete penetrance J:194821
small thymus J:40769
spleen hyperplasia J:40769
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory