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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl6
B cell leukemia/lymphoma 6
MGI:107187
77 phenotypes from 8 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl6tm1.1Dent/Bcl6tm1.1Dent
involves: 129S/SvEv * C57BL/6 * FVB/N 		no abnormal phenotype detected J:202372
Bcl6tm1.1Dent/Bcl6tm1.1Dent
Tg(Cd4-cre)1Cwi/0
involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N 		abnormal T follicular helper cell differentiation J:202372
decreased germinal center B cell number J:202372
decreased IgG level J:202372
decreased interleukin-4 secretion J:202372
decreased T follicular helper cell number J:202372
increased interleukin-10 secretion J:202372
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 * C57BL/6JJcl 		abnormal humoral immune response J:190943
abnormal memory B cell morphology J:190943
abnormal memory B cell physiology J:190943
abnormal somatic hypermutation frequency J:190943
decreased germinal center B cell number J:190943
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Cd79atm1(cre)Reth/Cd79a+
Tg(Cd4-cre)1Cwi/0
involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2 		decreased germinal center B cell number J:190943
normal immune system phenotype J:190943
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl 		decreased germinal center B cell number J:190943
normal immune system phenotype J:190943
Bcl6tm1.1Mtto/Bcl6tm1.1Mtto
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * C57BL/6JJcl * DBA/2 		abnormal humoral immune response J:190943
abnormal somatic hypermutation frequency J:190943
absent germinal center B cells J:190943
decreased germinal center B cell number J:190943
decreased T follicular helper cell number J:190943
Bcl6tm1.1Toka/Bcl6tm1.1Toka
involves: C57BL/6 * NZB 		abnormal Peyer's patch morphology J:174014
decreased germinal center B cell number J:174014
decreased T follicular helper cell number J:174014
normal immune system phenotype J:174014
Bcl6tm1Gdba/Bcl6tm1Gdba
Tg(ACTA1-rtTA,tetO-cre)102Monk/0
involves: C3H * C57BL/6 		increased body fat mass J:271078
increased white adipose tissue amount J:271078
increased white fat cell size J:271078
Bcl6tm1Gdba/Bcl6tm1Gdba
Tg(Adipoq-cre)1Evdr/0
involves: C57BL/6 * FVB/NJ 		abnormal gonadal fat pad morphology J:271078
abnormal lipid level J:271078
decreased adipocyte glucose uptake J:271078
decreased ceramide level J:271078
decreased circulating free fatty acids level J:271078
decreased circulating insulin level J:271078
decreased circulating triglyceride level J:271078
decreased fasting circulating glucose level J:271078
decreased liver triglyceride level J:271078
decreased liver weight J:271078
decreased respiratory quotient J:271078
decreased susceptibility to diet-induced hepatic steatosis J:271078
impaired gluconeogenesis J:271078
increased adipocyte glucose uptake J:271078
increased body fat mass J:271078
increased circulating adiponectin level J:271078
increased circulating leptin level J:271078
increased insulin sensitivity J:271078
increased lipogenesis J:271078
increased skeletal muscle cell glucose uptake J:271078
increased subcutaneous adipose tissue amount J:271078
increased susceptibility to diet-induced obesity J:271078
increased white fat cell size J:271078
white adipose tissue inflammation J:271078
Bcl6tm1Htno/Bcl6+
involves: 129S1/Sv * 129X1/SvJ 		abnormal apoptosis J:82037
Bcl6tm1Htno/Bcl6tm1Htno
involves: 129S1/Sv * 129X1/SvJ 		decreased fertilization frequency J:82037
increased male germ cell apoptosis J:82037
oligozoospermia J:82037
reduced male fertility J:82037
Bcl6tm1Htno/Bcl6tm1Htno
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal spleen morphology J:55952
cardiac interstitial fibrosis J:55952
decreased body size J:55952
decreased body weight J:55952
dilated heart ventricle J:55952
lung inflammation J:55952
myocardial fiber degeneration J:55952
myocarditis J:55952
postnatal lethality, incomplete penetrance J:55952
premature death J:55952
thin ventricular wall J:55952
Bcl6tm1Rdf/Bcl6tm1Rdf
involves: 129S1/Sv 		abnormal B cell physiology J:40769
abnormal humoral immune response J:40769
abnormal immune system morphology J:40769
abnormal immune system physiology J:40769
abnormal Peyer's patch germinal center morphology J:40769
abnormal T-helper 2 physiology J:40769
absent lymph node germinal center J:40769
absent spleen germinal center J:40769
decreased IgG level J:40769
decreased IgM level J:40769
heart inflammation J:40769
increased eosinophil cell number J:40769
increased inflammatory response J:40769
increased susceptibility to bacterial infection J:40769
liver inflammation J:40769
lung inflammation J:40769
postnatal growth retardation J:40769
small thymus J:40769
spleen hyperplasia J:40769
Bcl6tm1Sdt/Bcl6tm1Sdt
involves: 129/Sv * C57BL/6 		abnormal blood cell morphology/development J:123621
abnormal chemokine level J:123621
abnormal immune system physiology J:123621
decreased bone marrow cell number J:123621
postnatal growth retardation J:123621
postnatal lethality, incomplete penetrance J:123621
spleen hypoplasia J:123621
Bcl6tm2Rdf/Bcl6tm2Rdf
involves: 129S1/Sv 		abnormal B cell physiology J:40769
abnormal humoral immune response J:40769
abnormal immune system morphology J:40769
abnormal immune system physiology J:40769
abnormal Peyer's patch germinal center morphology J:40769
abnormal T-helper 2 physiology J:40769
absent lymph node germinal center J:40769
absent spleen germinal center J:40769
decreased B cell proliferation J:40769
decreased body size J:194821
decreased IgG level J:40769
decreased IgM level J:40769
heart inflammation J:40769
increased eosinophil cell number J:40769
increased inflammatory response J:40769
increased susceptibility to bacterial infection J:40769
liver inflammation J:40769
lung inflammation J:40769
postnatal growth retardation J:40769
prenatal lethality, incomplete penetrance J:194821
small thymus J:40769
spleen hyperplasia J:40769
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory