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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atm
ataxia telangiectasia mutated
MGI:107202
138 phenotypes from 18 alleles in 30 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atmm1Btlr/Atmm1Btlr
C57BL/6J-Atmm1Btlr 		decreased CD4-positive, alpha-beta T cell number J:265252
decreased CD8-positive, alpha-beta T cell number J:265252
decreased response to antigen J:265252
decreased single-positive T cell number J:265252
decreased T cell number J:265252
impaired humoral immune response J:265252
increased IgM level J:265252
Atmm2Btlr/Atmm2Btlr
C57BL/6J-Atmm2Btlr 		decreased CD4-positive, alpha-beta T cell number J:265253
decreased CD8-positive, naive alpha-beta T cell number J:265253
decreased single-positive T cell number J:265253
increased central memory CD8 positive, alpha-beta T cell number J:265253
increased effector memory CD4-positive, alpha-beta T cell number J:265253
Atmm3Btlr/Atmm3Btlr
C57BL/6J-Atmm3Btlr 		increased B-1a cell number J:272820
increased macrophage cell number J:272820
AtmM4Btlr/AtmM4Btlr
C57BL/6J-AtmM4Btlr 		abnormal CD8-positive, alpha-beta T cell differentiation J:272821
Atmm5Btlr/Atmm5Btlr
C57BL/6J-Atmm5Btlr 		abnormal lymphocyte morphology J:272824
decreased interleukin-1 beta secretion J:272824
impaired macrophage phagocytosis J:272824
increased B-1 B cell number J:272824
Atmm6Btlr/Atmm6Btlr
C57BL/6J-Atmm6Btlr 		abnormal CD4-positive T cell differentiation J:274964
abnormal CD8-positive, alpha-beta T cell differentiation J:274964
abnormal T cell differentiation J:274964
decreased CD4-positive, alpha-beta T cell number J:274964
decreased CD8-positive, naive alpha-beta T cell number J:274964
decreased T cell number J:274964
increased CD8-positive, alpha-beta memory T cell number J:274964
increased central memory CD4-positive, alpha-beta T cell number J:274964
increased central memory CD8 positive, alpha-beta T cell number J:274964
increased effector memory CD4-positive, alpha-beta T cell number J:274964
Atmtm1.1Mmpl/Atmtm1.1Mmpl
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J 		abnormal DNA repair J:226414
ataxia J:226414
decreased cell proliferation J:226414
decreased sensitivity to induced cell death J:226414
decreased T cell number J:226414
increased B cell number J:226414
increased T cell derived lymphoma incidence J:226414
lethality, incomplete penetrance J:226414
normal nervous system phenotype J:226414
Atmtm1.1Shzh/Atmtm1.1Shzh
involves: 129S4/SvJae * 129S6/SvEvTac 		embryonic lethality, complete penetrance J:191288
Atmtm1Awb/Atmtm1Awb
129S6/SvEvTac-Atmtm1Awb 		decreased body weight J:208539
increased T cell derived lymphoma incidence J:208539
normal mortality/aging J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
129S6/SvEvTac-Atmtm1Awb/J 		decreased single-positive T cell number J:226414
decreased T cell number J:226414
increased B cell number J:226414
increased double-positive T cell number J:226414
increased T cell derived lymphoma incidence J:226414
Atmtm1Awb/Atmtm1Awb
A.129S6-Atmtm1Awb 		abnormal tumor susceptibility J:208539
decreased body weight J:208539
increased hepatocellular carcinoma incidence J:208539
lethality, incomplete penetrance J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
A.129S6-Atmtm1Awb/J 		increased mortality induced by gamma-irradiation J:236776
Atmtm1Awb/Atmtm1Awb
B6.129S6-Atmtm1Awb 		abnormal tumor incidence J:208539
decreased body weight J:208539
lethality, incomplete penetrance J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
CByJ.129S6-Atmtm1Awb 		decreased body weight J:208539
increased T cell derived lymphoma incidence J:208539
normal mortality/aging J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
either: 129S6/SvEvTac-Atmtm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss) 		abnormal cell cycle J:34193
abnormal female reproductive system morphology J:34193
abnormal gametogenesis J:34193
abnormal lysosome morphology J:59933
abnormal male reproductive system morphology J:34193
abnormal Purkinje cell morphology J:57115
abnormal reproductive system physiology J:34193
abnormal seminiferous tubule morphology J:34193
abnormal uterus morphology J:34193
absent estrous cycle J:34193
absent estrus J:34193
absent oocytes J:34193
absent ovarian follicles J:34193
arrest of spermatogenesis J:34193
azoospermia J:34193
decreased activated T cell number J:34193
decreased body size J:34193
decreased body weight J:34193
decreased double-positive T cell number J:34193
decreased fibroblast proliferation J:34193
decreased locomotor activity J:34193
decreased T cell number J:34193
decreased vertical activity J:34193
female infertility J:34193
normal immune system phenotype J:34193
impaired coordination J:34193
increased cellular sensitivity to gamma-irradiation J:34193
increased double-positive T cell number J:34193
increased mortality induced by gamma-irradiation J:34193
increased T cell derived lymphoma incidence J:34193
male infertility J:34193
normal nervous system phenotype J:34193
oxidative stress J:57115
premature death J:34193
short stride length J:34193
small ovary J:34193
small testis J:34193
Atmtm1Awb/Atmtm1Awb
either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1 		decreased body weight J:208539
increased T cell derived lymphoma incidence J:208539
normal mortality/aging J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1 		decreased body weight J:208539
increased T cell derived lymphoma incidence J:208539
normal mortality/aging J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 		abnormal tumor incidence J:208539
decreased body weight J:208539
normal mortality/aging J:208539
premature death J:208539
Atmtm1Awb/Atmtm1Awb
involves: 129S6/SvEvTac 		abnormal cell cycle checkpoint function J:126920
abnormal chromosome morphology J:170462
abnormal class switch recombination J:150435
normal cellular phenotype J:126186
decreased body weight J:90941
decreased CD4-positive, alpha-beta T cell number J:90941
decreased CD8-positive, alpha-beta T cell number J:90941
normal immune system phenotype J:126920
increased mortality induced by gamma-irradiation J:90941
increased T cell derived lymphoma incidence J:90941
premature death J:90941
spontaneous chromosome breakage J:150435
Atmtm1Awb/Atmtm1Awb
involves: 129S6/SvEvTac * C57BL/6 		abnormal cell cycle checkpoint function J:103922
chromosome breakage J:103922
increased T cell derived lymphoma incidence J:103922
premature death J:103922
Atmtm1Bal/Atmtm1Bal
involves: 129S4/SvJae 		abnormal cell cycle checkpoint function J:42324
abnormal cerebellar granule cell morphology J:44190
abnormal cerebellar molecular layer J:44190
abnormal female meiosis J:35914
abnormal microglial cell physiology J:44190
abnormal T cell physiology J:35914
absent oocytes J:35914
absent ovarian follicles J:35914
arrest of male meiosis J:35914
normal behavior/neurological phenotype J:35914
decreased body weight J:35914
decreased fibroblast proliferation J:42324
decreased IgG2a level J:35914
decreased IgG2b level J:35914
decreased IgG3 level J:35914
decreased IgG level J:35914
decreased pre-B cell number J:35914
decreased thymocyte number J:35914
decreased tumor-free survival time J:35914
female infertility J:35914
increased cellular sensitivity to gamma-irradiation J:42324
increased T cell derived lymphoma incidence J:35914
male infertility J:35914
neuron degeneration J:44190
ovary degeneration J:35914
postnatal growth retardation J:35914
Purkinje cell degeneration J:44190
small thymus J:35914
Atmtm1Fwa/Atmtm1Fwa
involves: 129S4/SvJae 		abnormal class switch recombination J:191288
chromosomal instability J:191288
normal mortality/aging J:191288
Atmtm1Fwa/Atmtm1Fwa
involves: 129S4/SvJae * C57BL/6 		abnormal motor learning J:61201
abnormal Purkinje cell axon morphology J:61201
abnormal Purkinje cell dendrite morphology J:61201
decreased body weight J:61201
decreased immature B cell number J:61201
decreased locomotor activity J:61201
decreased lymphocyte cell number J:61201
decreased pre-B cell number J:61201
decreased splenocyte number J:61201
decreased T cell number J:61201
decreased thymocyte number J:61201
ectopic Purkinje cell J:61201
female infertility J:61201
increased cellular sensitivity to gamma-irradiation J:61201
increased T cell derived lymphoma incidence J:61201
male infertility J:61201
postnatal growth retardation J:61201
premature death J:61201
thin cerebellar molecular layer J:61201
Atmtm1Led/Atmtm1Led
involves: 129S6/SvEvTac * Black Swiss 		abnormal chromosome morphology J:69726
abnormal Purkinje cell morphology J:86894
abnormal T cell differentiation J:36561
abnormal testis morphology J:36561
azoospermia J:36561
chromosome breakage J:36561
decreased body size J:36561
decreased body weight J:36561
decreased CD4-positive, alpha-beta T cell number J:36561
increased cellular sensitivity to ionizing radiation J:69726
increased double-positive T cell number J:36561
increased T cell derived lymphoma incidence J:69726
increased thymoma incidence J:36561
male infertility J:36561
premature death J:69726
small testis J:36561
small thymus J:36561
thymus cortex hypoplasia J:36561
Atmtm1Mfl/Atm+
involves: 129T2/SvEms * C57BL/6J 		increased adenoma incidence J:78527
increased leukemia incidence J:78527
increased lymphoma incidence J:78527
increased ovary tumor incidence J:78527
increased sarcoma incidence J:78527
increased tumor incidence J:78527
Atmtm1Mfl/Atmtm1Mfl
involves: 129T2/SvEms * C57BL/6J 		abnormal chromosome morphology J:69726
abnormal gametogenesis J:69726
abnormal immune system cell morphology J:69726
abnormal immune system organ morphology J:69726
abnormal oogenesis J:69726
abnormal Purkinje cell morphology J:86894
abnormal spermatid morphology J:69726
abnormal spermatocyte morphology J:69726
abnormal spermatogenesis J:69726
abnormal T cell differentiation J:69726
abnormal testis development J:69726
decreased body size J:69726
decreased thymocyte number J:69726
enlarged spleen J:69726
increased cellular sensitivity to ionizing radiation J:69726
increased double-negative T cell number J:69726
increased single-positive T cell number J:69726
increased T cell derived lymphoma incidence J:69726
increased tumor incidence J:69726
normal nervous system phenotype J:69726
postnatal growth retardation J:69726
premature death J:69726
seminiferous tubule degeneration J:69726
small lymph nodes J:69726
small spleen J:69726
small thymus J:69726
Atmtm1Pmc/Atm+
B6.Cg-Atmtm1Pmc 		impaired glucose tolerance J:222034
insulin resistance J:222034
Atmtm1Pmc/Atmtm1Pmc
B6.Cg-Atmtm1Pmc 		abnormal adipose tissue distribution J:222034
abnormal cell cycle J:222034
abnormal fat cell differentiation J:222034
decreased circulating adiponectin level J:222034
decreased circulating leptin level J:222034
decreased subcutaneous adipose tissue amount J:222034
impaired glucose tolerance J:222034
increased food intake J:222034
insulin resistance J:222034
Atmtm1Pmc/Atmtm1Pmc
involves: 129X1/SvJ * C57BL/6 		decreased cellular sensitivity to ionizing radiation J:47752
increased lymphoma incidence J:47752
infertility J:47752
Atmtm1Pmc/Atmtm1Pmc
Not Specified 		abnormal cell cycle checkpoint function J:78491
decreased cellular sensitivity to gamma-irradiation J:78491
Atmtm1Shzh/Atmtm2.1Fwa
involves: 129S6/SvEvTac 		chromosomal instability J:191288
Atmtm1Shzh/Atmtm2.1Fwa
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
involves: 129 * 129S6/SvEvTac 		abnormal class switch recombination J:191288
chromosomal instability J:191288
Atmtm2.1Fwa/Atmtm2.1Fwa
Tg(VAV1-cre)1Graf/0
involves: 129S6/SvEvTac 		decreased B cell number J:277750
decreased T cell number J:277750
decreased thymocyte number J:277750
increased T cell derived lymphoma incidence J:277750
Atmtm2.1Mfgc/Atmtm2.1Mfgc
C57BL/6-Atmtm2.1Mfgc 		abnormal T cell differentiation J:316365
normal behavior/neurological phenotype J:316365
decreased survivor rate J:316365
decreased T cell number J:316365
increased thymoma incidence J:316365
premature death J:316365
Atmtm2Pmc/Atmtm2Pmc
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor * C57BL/6J 		decreased cellular sensitivity to ionizing radiation J:181920
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11/12/2024
MGI 6.24 		The Jackson Laboratory