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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atm
ataxia telangiectasia mutated
MGI:107202
66 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aptxtm1Pmc/Aptx+
Atmtm2.1Mfgc/Atmtm2.1Mfgc
involves: 129 * C57BL/6 		decreased survivor rate J:316365
increased thymoma incidence J:316365
Aptxtm1Pmc/Aptxtm1Pmc
Atmtm2.1Mfgc/Atmtm2.1Mfgc
involves: 129 * C57BL/6 		abnormal CD4-positive helper T cell morphology J:316365
abnormal gait J:316365
abnormal motor coordination/balance J:316365
abnormal nervous system electrophysiology J:316365
abnormal Purkinje cell dendrite morphology J:316365
abnormal Purkinje cell morphology J:316365
abnormal synaptic physiology J:316365
abnormal T cell differentiation J:316365
ataxia J:316365
cerebellum atrophy J:316365
decreased body weight J:316365
decreased survivor rate J:316365
decreased T cell number J:316365
impaired coordination J:316365
impaired neuron physiology J:316365
impaired righting response J:316365
increased CD8-positive, alpha-beta T cell number J:316365
increased excitatory postsynaptic current frequency J:316365
increased thymoma incidence J:316365
neurodegeneration J:316365
slow postnatal weight gain J:316365
thin cerebellar molecular layer J:316365
Atmtm1Awb/Atm+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		abnormal seminiferous tubule morphology J:209141
abnormal testis size J:209141
normal hematopoietic system phenotype J:209141
normal nervous system phenotype J:209141
Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		anemia J:103922
decreased macrophage cell number J:103922
increased lymphoma incidence J:103922
premature death J:103922
Atmtm1Awb/Atmtm1Awb
Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		thin cerebral cortex J:224364
Atmtm1Awb/Atmtm1Awb
Nbntm1Jpt/Nbntm1Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		embryonic lethality, complete penetrance J:75956
Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129S6/SvEvTac * 129/Sv 		decreased cellular sensitivity to ionizing radiation J:129762
Atmtm1Awb/Atmtm1Awb
Paxxem1Spj/Paxxem1Spj
involves: A/J * C57BL/6NTac 		abnormal class switch recombination J:236776
decreased B cell number J:236776
decreased splenocyte number J:236776
decreased T cell number J:236776
normal mortality/aging J:236776
Atmtm1Awb/Atmtm1Awb
Pim1tm1Mjn/Pim1+
involves: 129 * 129S6/SvEvTac * C57BL/6J 		normal cellular phenotype J:194229
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129 * C57BL * FVB/N * SJL 		increased tumor incidence J:120284
premature death J:120284
Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle checkpoint function J:103922
anemia J:103922
normal cellular phenotype J:103922
chromosome breakage J:103922
increased lymphoma incidence J:103922
premature death J:103922
Atmtm1Awb/Atmtm1Awb
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 		increased tumor latency J:209141
Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
involves: 129P2/OlaHsd * 129S6/SvEvTac 		decreased body weight J:90941
decreased CD4-positive, alpha-beta T cell number J:90941
decreased CD8-positive, alpha-beta T cell number J:90941
decreased lymphoma incidence J:90941
increased mortality induced by gamma-irradiation J:90941
increased T cell derived lymphoma incidence J:90941
premature death J:90941
Atmtm1Fwa/Atmtm1Fwa
H2axtm1Fwa/H2axtm1Fwa
involves: 129S4/SvJae * 129S6/SvEvTac 		chromosomal instability J:138190
embryonic lethality during organogenesis, complete penetrance J:138190
increased cell death J:138190
spontaneous chromosome breakage J:138190
Atmtm1Fwa/Atmtm1Fwa
Pknox1tm1Fbla/Pknox1+
involves: 129S4/SvJae * C57BL/6 		embryonic growth retardation J:165811
Atmtm1Fwa/Atmtm1Fwa
Pknox1tm1Fbla/Pknox1tm1Fbla
involves: 129S4/SvJae * C57BL/6 		abnormal pluripotent precursor cell morphology J:165811
embryonic growth retardation J:165811
embryonic lethality between implantation and somite formation, incomplete penetrance J:165811
Atmtm1Led/Atm+
Kat8tm2Thl/Kat8+
involves: 129S1/Sv * 129S6/SvEvTac 		premature death J:128936
Atmtm1Led/Atmtm1Led
Kat8tm2Thl/Kat8+
involves: 129S1/Sv * 129S6/SvEvTac 		decreased body weight J:128936
premature death J:128936
Atmtm1Pmc/Atm+
Lig4tm1Icrf/Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:65540
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Icrf/Lig4+
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:65540
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Icrf/Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		decreased body size J:65540
decreased neuron apoptosis J:65540, J:111068
neonatal lethality, complete penetrance J:65540, J:111068
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Icrf/Lig4tm1Icrf
involves: 129 		decreased cellular sensitivity to ionizing radiation J:144172
perinatal lethality J:144172
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * C57BL/6 * SJL 		ataxia J:144172
normal nervous system phenotype J:144172
Atmtm1Pmc/Atmtm1Pmc
Trp73tm2Mak/Trp73tm2Mak
involves: 129P2/OlaHsd * C57BL/6J 		decreased cellular sensitivity to gamma-irradiation J:157905
decreased thymocyte apoptosis J:157905
Atmtm2Pmc/Atmtm2Pmc
Atrtm2Bal/Atrtm2Bal
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal nervous system morphology J:181920
abnormal neuron apoptosis J:181920
decreased cellular sensitivity to ionizing radiation J:181920
Atmtm2Pmc/Atmtm2Pmc
Pnkptm1.1Pmc/Pnkptm1.1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal brain interneuron morphology J:226703
increased brain apoptosis J:226703
intracranial hemorrhage J:226703
Xrcc2tm1Pmc/Xrcc2tm1Pmc
Atmtm1Pmc/Atmtm1Pmc
involves: 129S1/Sv 		embryonic lethality during organogenesis, complete penetrance J:111068
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory