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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dlg1
discs large MAGUK scaffold protein 1
MGI:107231
78 phenotypes from 8 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dlg1Gt(gt1.8geo)1Ber/Dlg1Gt(gt1.8geo)1Ber
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal kidney development J:114313
abnormal lens epithelium morphology J:86871
abnormal palatal shelf elevation J:67360
absent gastric milk in neonates J:67360
cleft secondary palate J:67360
curly tail J:67360
cyanosis J:67360
decreased body size J:67360
decreased embryo weight J:114313
decreased fetal size J:114313
decreased nephron number J:114313
decreased renal glomerulus number J:114313
distended abdomen J:67360
domed cranium J:67360
fetal growth retardation J:67360
kinked tail J:67360
mandible hypoplasia J:67360
meteorism J:67360
neonatal lethality, complete penetrance J:67360
premaxilla hypoplasia J:67360
short snout J:67360
small metanephros J:114313
Dlg1Gt(RRN196)Byg/Dlg1Gt(RRN196)Byg
involves: 129P2/OlaHsd * C57BL/6J 		neonatal lethality, complete penetrance J:191788
Dlg1tm1.1Agri/Dlg1tm1.1Agri
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		normal vision/eye phenotype J:151538
Dlg1tm1.1Agri/Dlg1tm1.1Agri
Tg(Cryaa-cre)10Mlr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal lens development J:151538
abnormal lens epithelium morphology J:151538
abnormal lens fiber morphology J:151538
abnormal lens morphology J:151538
cataract J:151538
disorganized lens bow J:151538
increased lens epithelium apoptosis J:151538
increased lens fiber apoptosis J:151538
Dlg1tm1.1Agri/Dlg1tm1.1Agri
Tg(Cryaa-cre,Tyr)39Mlr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal lens development J:151538
abnormal lens fiber morphology J:151538
abnormal lens morphology J:151538
disorganized lens bow J:151538
increased lens fiber apoptosis J:151538
Dlg1tm1.2Agri/Dlg1tm1.2Agri
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal craniofacial morphology J:151538
abnormal lens morphology J:151538
Dlg1tm1Jhm/Dlg1tm1Jhm
involves: 129 * C57BL/6J 		abnormal ureter development J:118250
abnormal ureter morphology J:118250
abnormal ureter smooth muscle morphology J:118250
abnormal ureteric bud morphology J:118250
decreased nephron number J:118250
dilated kidney collecting duct J:118250
hydronephrosis J:118250
hydroureter J:118250
impaired branching involved in ureteric bud morphogenesis J:118250
impaired smooth muscle contractility J:118250
impaired ureteric peristalsis J:118250
neonatal lethality, complete penetrance J:118250
renal hypoplasia J:118250
respiratory distress J:118250
short ureter J:118250
single kidney J:118250
Dlg1tm1Jhm/Dlg1tm1Jhm
Tg(Vil1-cre)997Gum/0
involves: 129 * C57BL/6 * SJL 		abnormal enterocyte morphology J:146174
Dlg1tm1Rlh/Dlg1tm1.1Rlh
Tg(Mpz-cre)26Mes/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac 		normal nervous system phenotype J:202688
Dlg1tm1Rlh/Dlg1tm1Rlh
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal dendrite morphology J:141127
Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal CD4-positive, alpha-beta T cell physiology J:191788
abnormal cytokine secretion J:191788
abnormal T-helper 1 physiology J:191788
abnormal T-helper 2 physiology J:191788
decreased interferon-gamma secretion J:191788
decreased interleukin-2 secretion J:191788
decreased tumor necrosis factor secretion J:191788
increased interleukin-4 secretion J:191788
increased interleukin-5 secretion J:191788
Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(CMV-cre)1Nagy/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal craniofacial morphology J:141127
neonatal lethality J:141127
Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Mpz-cre)26Mes/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac 		hypermyelination J:202688
Dlg1tm1Taki/Dlg1tm1Taki
involves: C57BL/6 * CBA 		abnormal intestine morphology J:121262
abnormal metanephric mesenchyme morphology J:121262
abnormal Mullerian duct morphology J:121262
abnormal reproductive system morphology J:121262
abnormal ureter development J:121262
abnormal ureter morphology J:121262
abnormal ureter urothelium morphology J:121262
abnormal uterus morphology J:121262
abnormal Wolffian duct morphology J:121262
absent seminal vesicle J:121262
absent vagina J:121262
bifid ureter J:121262
blind uterus J:121262
cleft palate J:121262
cryptorchism J:121262
decreased body length J:121262
decreased lung weight J:121262
dilated ureter J:121262
ectopic ovary J:121262
hydronephrosis J:121262
large ureter J:121262
neonatal lethality, complete penetrance J:121262
renal hypoplasia J:121262
ureter hypoplasia J:121262
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory