Polr2m Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Polr2m
polymerase (RNA) II (DNA directed) polypeptide M
MGI:107282

5 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Polr2m^tm1.1Rgr/Polr2m^tm1.1Rgr Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S2/SvPas * C57BL/6	increased hepatocyte karyomegaly	J:291184
	increased hepatocyte proliferation	J:291184
Polr2m^tm1.1Rgr/Polr2m^tm1.1Rgr Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S2/SvPas * C57BL/6 * DBA	abnormal hepatocyte morphology	J:291184
	abnormal liver morphology	J:291184
	increased hepatocyte apoptosis	J:291184
	increased hepatocyte proliferation	J:291184

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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