Il17a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il17a
interleukin 17A
MGI:107364

49 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm3(CAG-Il17a)Awai}/Gt(ROSA)26Sor⁺ Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal immune system physiology	J:144710
	abnormal neutrophil physiology	J:144710
	increased circulating interleukin-17 level	J:144710
	increased granulocyte number	J:144710
	increased interleukin-17 secretion	J:144710
Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}/Gt(ROSA)26Sor⁺ involves: BALB/c * C57BL/6	anemia	J:144710
	decreased hematocrit	J:144710
	decreased hemoglobin content	J:144710
	decreased mean corpuscular hemoglobin	J:144710
	decreased mean corpuscular volume	J:144710
	increased granulocyte number	J:144710
	increased interleukin-17 secretion	J:144710
	postnatal growth retardation	J:144710
	skin inflammation	J:144710
Il17a/Il17f^tm1.1Impr/Il17a/Il17f^tm1.1Impr involves: C57BL/6	abnormal effector T cell morphology	J:187400
	absent gamma-delta T cells	J:187400
	decreased interleukin-17 secretion	J:187400
	normal immune system phenotype	J:187400, J:189794
	increased gamma-delta T cell number	J:187400
	increased T cell proliferation	J:187400
Il17a^em1(IMPC)Mbp/Il17a^em1(IMPC)Mbp C57BL/6N-Il17a^em1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal spleen morphology	J:211773
	enlarged spleen	J:211773
	increased freezing behavior	J:211773
	small kidney	J:211773
	small liver	J:211773
Il17a^tm1Cdon/Il17a^tm1Cdon involves: C57BL/6	chronic inflammation	J:136279
	decreased CD4-positive, alpha-beta T cell number	J:136279
	decreased IgG1 level	J:136279
	decreased IgG2a level	J:136279
	decreased IgG2b level	J:136279
	decreased IgM level	J:136279
	decreased interleukin-17 secretion	J:136279
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:136279
	increased susceptibility to induced colitis	J:136279
Il17a^tm1Yiw/Il17a^tm1Yiw B6.129P2-Il17a^tm1Yiw	increased susceptibility to infection induced morbidity/mortality	J:160680
Il17a^tm1Yiw/Il17a^tm1Yiw involves: 129P2/OlaHsd	abnormal immune system physiology	J:144710
	decreased neutrophil cell number	J:193548
	decreased physiological sensitivity to xenobiotic	J:193548
	increased gamma-delta T cell number	J:193548
Il17a^tm1Yiw/Il17a^tm1Yiw involves: 129P2/OlaHsd * BALB/cA * C57BL/6J	abnormal interleukin level	J:79127
	abnormal Langerhans cell physiology	J:79127
	decreased IgE level	J:79127
	decreased IgG1 level	J:79127
	decreased immunoglobulin level	J:79127
	decreased susceptibility to type IV hypersensitivity reaction	J:79127
Il17a^tm1Yiw/Il17a^tm1Yiw involves: 129P2/OlaHsd * C57BL/6	increased susceptibility to bacterial infection	J:143719
Il17a^tm1Yiw/Il17a^tm1Yiw involves: 129P2/OlaHsd * C57BL/6J	decreased IgG level	J:79127
	decreased immunoglobulin level	J:79127
	decreased interferon-gamma secretion	J:79127
	decreased susceptibility to type IV hypersensitivity reaction	J:79127
Tg(Scgb1a1-Il17a)3Cdon/0 C57BL/6-Tg(Scgb1a1-Il17a)3Cdon	abnormal bronchiole morphology	J:112600
	abnormal chemokine level	J:112600
	abnormal lung epithelium morphology	J:112600
	lung inflammation	J:112600
	thick pulmonary interalveolar septum	J:112600

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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