Dnm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnm1
dynamin 1
MGI:107384

31 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dnm1^Ftfl/Dnm1⁺ C57BL/6J-Dnm1^Ftfl	abnormal kindling response	J:163311
	abnormal seizure response to electrical stimulation	J:163311
	tonic seizures	J:163311
Dnm1^Ftfl/Dnm1⁺ FVB.B6-Dnm1^Ftfl/Frk	seizures	J:235711
Dnm1^Ftfl/Dnm1^Ftfl C57BL/6J-Dnm1^Ftfl	abnormal auditory brainstem response waveform shape	J:163311
	abnormal gait	J:163311
	abnormal Purkinje cell dendrite morphology	J:163311
	ataxia	J:163311
	convulsive seizures	J:163311
	impaired limb coordination	J:163311
	increased or absent threshold for auditory brainstem response	J:163311
	postnatal lethality, complete penetrance	J:163311
	tonic-clonic seizures	J:163311
Dnm1^Ftfl/Dnm1^Ftfl Tg(Pvalb-EGFP)B20Zjh/0 involves: C57BL/6 * C57BL/6J * FVB	abnormal Purkinje cell dendrite morphology	J:163311
Dnm1^Ftfl/Dnm1^tm1.2Frk involves: 129 * C57BL/6J * FVB	abnormal brain wave pattern	J:235711
	premature death	J:235711
	seizures	J:235711
Dnm1^Ftfl/Dnm1^tm1Pdc involves: C57BL/6J	abnormal motor capabilities/coordination/movement	J:163311
	hunched posture	J:163311
	tremors	J:163311
Dnm1^Ftfl/Dnm1^tm2.2Frk involves: 129 * C57BL/6J * FVB	seizures	J:235711
Dnm1^{tm1.1(KOMP)Vlcg}/Dnm1⁺ C57BL/6N-Dnm1^{tm1.1(KOMP)Vlcg}/Ucd	hemorrhage	J:211773
	spina bifida	J:211773
Dnm1^{tm1.1(KOMP)Vlcg}/Dnm1^{tm1.1(KOMP)Vlcg} C57BL/6N-Dnm1^{tm1.1(KOMP)Vlcg}/Ucd	hemorrhage	J:211773
	preweaning lethality, complete penetrance	J:211773
	spina bifida	J:211773
Dnm1^tm1.2Frk/Dnm1^tm1.2Frk B6.129(Cg)-Dnm1^tm1.2Frk	normal nervous system phenotype	J:235711
Dnm1^tm1Pdc/Dnm1^tm1Pdc involves: 129X1/SvJ * C57BL/6	abnormal CNS synaptic transmission	J:121111
	abnormal inhibitory postsynaptic currents	J:121111
	abnormal miniature excitatory postsynaptic currents	J:121111
	abnormal motor capabilities/coordination/movement	J:121111
	abnormal neuron morphology	J:121111
	abnormal suckling behavior	J:121111
	abnormal synaptic vesicle morphology	J:121111
	abnormal synaptic vesicle number	J:121111
	abnormal synaptic vesicle recycling	J:121111
	postnatal lethality, complete penetrance	J:121111
Dnm1^tm2.1Pdc/Dnm1^tm2.1Pdc involves: 129S1/SvImJ * C57BL/6	no abnormal phenotype detected	J:161127
Dnm1^tm2.2Frk/Dnm1^tm2.2Frk B6.129(Cg)-Dnm1^tm2.2Frk	normal nervous system phenotype	J:235711

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24