Aqp4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aqp4
aquaporin 4
MGI:107387

41 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aqp4^tm1.1Geno/Aqp4^tm1.1Geno Tg(GFAP-cre)25Mes/0 involves: C57BL/6J * FVB/N	abnormal blood-brain barrier function	J:177412
Aqp4^tm1.1Lmno/Aqp4^tm1.1Lmno B6.Cg-Aqp4^tm1.1Lmno	abnormal astrocyte physiology	J:168686
	abnormal blood-brain barrier function	J:177412
	cerebral edema	J:193622
	increased susceptibility to parasitic infection	J:193622
	increased susceptibility to parasitic infection induced morbidity/mortality	J:193622
Aqp4^tm1.1Mysi/Aqp4^tm1.1Mysi involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj	abnormal microglial cell physiology	J:214906
Aqp4^tm1.1Tsna/Aqp4^tm1.1Tsna involves: C57BL/6 * CBA	abnormal glial cell physiology	J:149545
Aqp4^tm1Ask/Aqp4^tm1Ask B6.Cg-Aqp4^tm1Ask	abnormal eye electrophysiology	J:109783
	deafness	J:71154
	retina ischemia	J:109783
Aqp4^tm1Ask/Aqp4^tm1Ask involves: C57BL/6J	abnormal eye electrophysiology	J:74263
	abnormal renal water transport	J:46296
	decreased urine osmolality	J:42704, J:46296
	normal endocrine/exocrine gland phenotype	J:56302
Aqp4^tm1Ask/Aqp4^tm1Ask involves: C57BL/6J * CD-1	abnormal auditory brainstem response waveform shape	J:71154
	abnormal fluid regulation	J:111923
	normal behavior/neurological phenotype	J:111923
	normal cardiovascular system phenotype	J:111923
	decreased susceptibility to induced morbidity/mortality	J:111923
	decreased susceptibility to ischemic brain injury	J:111923
	normal digestive/alimentary phenotype	J:63987
	normal homeostasis/metabolism phenotype	J:63987, J:111923
	impaired hearing	J:71154
	increased or absent threshold for auditory brainstem response	J:71154, J:79863
	normal nervous system phenotype	J:111923
	retina ischemia	J:109783
	unilateral deafness	J:79863
	normal vision/eye phenotype	J:62579, J:109783
Aqp4^tm1Gghu/Aqp4^tm1Gghu involves: 129P2/OlaHsd	abnormal uterus physiology	J:323125
	decreased corpora lutea number	J:323125
	decreased litter size	J:323125
	decreased ovary weight	J:323125
	decreased superovulation rate	J:323125
	decreased tertiary ovarian follicle number	J:323125
	decreased uterus weight	J:323125
	impaired ovarian folliculogenesis	J:323125
	reduced female fertility	J:323125
	small uterus	J:323125
	thin endometrium	J:323125
Aqp4^tm1Gghu/Aqp4^tm1Gghu involves: 129P2/OlaHsd * C57BL/6J	abnormal nervous system physiology	J:111202
	decreased physiological sensitivity to xenobiotic	J:111202
	impaired behavioral response to cocaine	J:111202
	increased dopamine level	J:111202

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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