Tbr1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbr1
T-box brain transcription factor 1
MGI:107404

41 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tbr1^{tm1.1(KOMP)Mbp}/Tbr1⁺ C57BL/6N-Tbr1^{tm1.1(KOMP)Mbp}/Ucd	decreased blood urea nitrogen level	J:211773
	decreased circulating creatinine level	J:211773
	decreased circulating glucose level	J:211773
	hemorrhage	J:211773
	spina bifida	J:211773
Tbr1^{tm1.1(KOMP)Mbp}/Tbr1^{tm1.1(KOMP)Mbp} C57BL/6N-Tbr1^{tm1.1(KOMP)Mbp}/Ucd	hemorrhage	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	spina bifida	J:211773
Tbr1^tm1.1Csbd/Tbr1⁺ involves: C57BL/6J	abnormal brain interneuron morphology	J:281878
	abnormal habituation to a new environment	J:281878
	abnormal social/conspecific interaction behavior	J:281878
	decreased thigmotaxis	J:281878
	increased anxiety-related response	J:281878
	increased excitatory postsynaptic current frequency	J:281878
	increased grooming behavior	J:281878
	increased locomotor activity	J:281878
	increased miniature inhibitory postsynaptic current frequency	J:281878
	increased vertical activity	J:281878
Tbr1^tm1.1Csbd/Tbr1^tm1.1Csbd involves: C57BL/6J	preweaning lethality, complete penetrance	J:281878
Tbr1^tm1Jlr/Tbr1⁺ B6.129X1-Tbr1^tm1Jlr	abnormal amygdala morphology	J:208050
	abnormal anterior commissure morphology	J:208050
	abnormal conditioned taste aversion behavior	J:208050
	abnormal cued conditioning behavior	J:208050
	abnormal innervation	J:208050
	abnormal neuron physiology	J:208050
	abnormal social investigation	J:208050
	cognitive inflexibility	J:208050
	decreased vocalization	J:208050
	impaired social transmission of food preference	J:208050
Tbr1^tm1Jlr/Tbr1^tm1Jlr involves: 129X1/SvJ	abnormal forebrain morphology	J:51888
	abnormal mitral cell morphology	J:51888
	abnormal olfactory bulb development	J:51888
	abnormal olfactory bulb external plexiform layer morphology	J:51888
	abnormal olfactory bulb glomerular layer morphology	J:51888
	abnormal olfactory bulb interneuron morphology	J:51888
	abnormal olfactory bulb mitral cell layer morphology	J:51888
	abnormal olfactory bulb tufted cell morphology	J:51888
	abnormal olfactory cortex morphology	J:51888
	abnormal olfactory tract morphology	J:51888
	aphagia	J:51888
	decreased brain size	J:51888
	olfactory bulb hypoplasia	J:51888
	postnatal lethality, complete penetrance	J:51888
Tbr1^tm1Jlr/Tbr1^tm1Jlr Tg(Mbp-MAPT/EGFP)#Eja/0 involves: 129X1/SvJ	abnormal innervation	J:169221

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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