Lefty1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lefty1
left right determination factor 1
MGI:107405

29 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lefty1^{tm1b(KOMP)Wtsi}/Lefty1⁺ C57BL/6N-Lefty1^{tm1b(KOMP)Wtsi}/Bay	abnormal gait	J:211773
	increased circulating potassium level	J:211773
	increased total body fat amount	J:211773
Lefty1^{tm1b(KOMP)Wtsi}/Lefty1^{tm1b(KOMP)Wtsi} C57BL/6N-Lefty1^{tm1b(KOMP)Wtsi}/Bay	preweaning lethality, complete penetrance	J:211773
Lefty1^tm1Hmd/Lefty1^tm1Hmd involves: 129P2/OlaHsd * C57BL/6Cr	abnormal azygos vein morphology	J:49052
	abnormal bronchus morphology	J:49052
	abnormal cardiac outflow tract development	J:49052
	abnormal heart and great vessel attachment	J:49052
	abnormal heart morphology	J:49052
	abnormal heart position or orientation	J:49052
	abnormal hepatic portal vein morphology	J:49052
	abnormal inferior vena cava morphology	J:49052
	abnormal left renal vein morphology	J:49052
	abnormal liver morphology	J:49052
	abnormal vein morphology	J:49052
	atrial septal defect	J:49052
	complete atrioventricular septal defect	J:49052
	double outlet right ventricle	J:49052
	embryonic lethality during organogenesis, incomplete penetrance	J:49052
	left atrial isomerism	J:49052
	left pulmonary isomerism	J:49052
	left-sided isomerism	J:49052
	postnatal lethality, incomplete penetrance	J:49052
	right aortic arch	J:49052
	situs inversus	J:49052
	transposition of great arteries	J:49052
	tricuspid valve atresia	J:49052
	ventricular septal defect	J:49052
Lefty1^tm1Hmd/Lefty1^tm1Hmd Tg(Hhex-EGFP)#Rbe/0 involves: 129P2/OlaHsd * C57BL/6 * CBA/J	abnormal anterior visceral endoderm cell migration	J:170681
Lefty1^tm1Sla/Lefty1^tm1Sla involves: 129/Sv * CD-1	left pulmonary isomerism	J:81339

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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