Lefty1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lefty1
left right determination factor 1
MGI:107405

23 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1	abnormal amniotic cavity morphology	J:81339
	abnormal embryonic epiblast morphology	J:81339
	abnormal lateral plate mesoderm morphology	J:81339
	abnormal paraxial mesoderm morphology	J:81339
	abnormal primitive streak formation	J:81339
	abnormal primitive streak morphology	J:81339
	absent somites	J:81339
	embryonic lethality during organogenesis, incomplete penetrance	J:81339
	embryonic-extraembryonic boundary constriction	J:81339
Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd Nodal^tm1Rob/Nodal⁺ involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1	abnormal developmental patterning	J:81339
	abnormal embryo development	J:81339
	abnormal embryonic tissue morphology	J:81339
	abnormal embryonic-extraembryonic boundary morphology	J:81339
Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Sla/Lefty1^tm1Sla involves: 129S7/SvEvBrd * CD-1	abnormal embryonic epiblast morphology	J:81339
	abnormal lateral plate mesoderm morphology	J:81339
	abnormal paraxial mesoderm morphology	J:81339
	abnormal primitive streak formation	J:81339
	abnormal primitive streak morphology	J:81339
	absent somites	J:81339
	embryonic lethality during organogenesis, incomplete penetrance	J:81339
	embryonic-extraembryonic boundary constriction	J:81339
Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Sla/Lefty1^tm1Sla Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S7/SvEvBrd * CD-1	abnormal developmental patterning	J:81339
	abnormal embryo development	J:81339
	abnormal embryonic tissue morphology	J:81339
	abnormal embryonic-extraembryonic boundary morphology	J:81339
Lefty1^tm1Hmd/Lefty1^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia involves: 129P2/OlaHsd * C57BL/6 * CBA	normal nervous system phenotype	J:122557
Nodal^tm1Hmd/Nodal⁺ Tg(Rr443-Lefty1,-lacZ)36Hmd/0 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)	abnormal cardiac outflow tract development	J:82703
	abnormal digestive system development	J:82703
	abnormal left-right axis patterning	J:82703
	abnormal liver morphology	J:82703
	dextrocardia	J:82703
	right atrial isomerism	J:82703
	right pulmonary isomerism	J:82703
	right-sided isomerism	J:82703
	small spleen	J:82703

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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