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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
MGI:107414
22 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tnfsf10tm1b(KOMP)Wtsi/Tnfsf10tm1b(KOMP)Wtsi
C57BL/6N-Tnfsf10tm1b(KOMP)Wtsi/Ucd 		increased circulating alanine transaminase level J:211773
Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
B6.129-Tnfsf10tm1Mjs 		abnormal negative T cell selection J:82145
normal hematopoietic system phenotype J:84838
normal immune system phenotype J:84838
increased IgG1 level J:82145
increased IgG2a level J:82145
increased interferon-gamma secretion J:82145
increased interleukin-2 secretion J:82145
increased susceptibility to autoimmune diabetes J:82145
increased susceptibility to experimental autoimmune encephalomyelitis J:101672
increased susceptibility to induced arthritis J:82145
thymus hyperplasia J:82145
Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
C.129-Tnfsf10tm1Mjs 		abnormal negative T cell selection J:82145
decreased susceptibility to bacterial infection J:87620
decreased susceptibility to bacterial infection induced morbidity/mortality J:87620
normal hematopoietic system phenotype J:84838
normal immune system phenotype J:84838
impaired natural killer cell mediated cytotoxicity J:73948
increased incidence of induced tumors J:73948
increased incidence of tumors by chemical induction J:73948
liver inflammation J:87620
thymus hyperplasia J:82145, J:84838
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
B6.129-Tnfsf10tm1Sdg 		normal immune system phenotype J:79085
normal neoplasm J:79085
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
C.129-Tnfsf10tm1Sdg 		increased susceptibility to induced morbidity/mortality J:79085
increased tumor growth/size J:79085
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
involves: 129 * C57BL/6 		normal immune system phenotype J:79085
normal skeleton phenotype J:79085
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory