About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
MGI:107414
22 phenotypes from 3 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tnfsf10tm1b(KOMP)Wtsi/Tnfsf10tm1b(KOMP)Wtsi
C57BL/6N-Tnfsf10tm1b(KOMP)Wtsi/Ucd 		increased circulating alanine transaminase level J:211773
Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
B6.129-Tnfsf10tm1Mjs 		abnormal negative T cell selection J:82145
normal hematopoietic system phenotype J:84838
normal immune system phenotype J:84838
increased IgG1 level J:82145
increased IgG2a level J:82145
increased interferon-gamma secretion J:82145
increased interleukin-2 secretion J:82145
increased susceptibility to autoimmune diabetes J:82145
increased susceptibility to experimental autoimmune encephalomyelitis J:101672
increased susceptibility to induced arthritis J:82145
thymus hyperplasia J:82145
Tnfsf10tm1Mjs/Tnfsf10tm1Mjs
C.129-Tnfsf10tm1Mjs 		abnormal negative T cell selection J:82145
decreased susceptibility to bacterial infection J:87620
decreased susceptibility to bacterial infection induced morbidity/mortality J:87620
normal hematopoietic system phenotype J:84838
normal immune system phenotype J:84838
impaired natural killer cell mediated cytotoxicity J:73948
increased incidence of induced tumors J:73948
increased incidence of tumors by chemical induction J:73948
liver inflammation J:87620
thymus hyperplasia J:82145, J:84838
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
B6.129-Tnfsf10tm1Sdg 		normal immune system phenotype J:79085
normal neoplasm J:79085
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
C.129-Tnfsf10tm1Sdg 		increased susceptibility to induced morbidity/mortality J:79085
increased tumor growth/size J:79085
Tnfsf10tm1Sdg/Tnfsf10tm1Sdg
involves: 129 * C57BL/6 		normal immune system phenotype J:79085
normal skeleton phenotype J:79085
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory