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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Numb
NUMB endocytic adaptor protein
MGI:107423
38 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Emx1tm1(cre)Krj/Emx1+
Numbtm1Ynj/Numbtm1Ynj
involves: 129S2/SvPas * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:87149
Numbtm1.1Ynj/Numbtm1.1Ynj
involves: 129X1/SvJ * FVB/N 		abnormal forebrain development J:62712
abnormal neuron differentiation J:62712
decreased embryo size J:62712
embryo tissue necrosis J:62712
embryonic lethality during organogenesis, complete penetrance J:62712
open neural tube J:62712
small embryonic telencephalon J:62712
Numbtm1.1Zili/Numbtm1.1Zili
involves: 129/Sv * FVB/N 		abnormal developmental patterning J:68652
abnormal dorsal root ganglion morphology J:68652
abnormal embryonic tissue morphology J:68652
abnormal extraembryonic tissue morphology J:68652
abnormal heart morphology J:68652
abnormal hindbrain development J:68652
abnormal neuron differentiation J:68652
abnormal placental labyrinth vasculature morphology J:68652
abnormal spongiotrophoblast layer morphology J:68652
abnormal vascular regression J:68652
abnormal vitelline vasculature morphology J:68652
caudal body truncation J:68652
delayed embryo turning J:68652
embryonic growth retardation J:68652
embryonic lethality during organogenesis, complete penetrance J:68652
failure of initiation of embryo turning J:68652
open neural tube J:68652
pericardial edema J:68652
thin placenta labyrinth J:68652
Numbtm1Ynj/Numbtm1Ynj
involves: 129X1/SvJ 		no abnormal phenotype detected J:62712
Numbtm1Ynj/Numbtm1Ynj
Tg(Nes-cre)1Wmz/0
involves: 129X1/SvJ 		no abnormal phenotype detected J:79917
Numbtm1Zili/Numbtm1Zili
Tg(En2-cre)3Alj/?
involves: 129/Sv * C57BL/6 		abnormal cerebellar granule layer morphology J:87408
abnormal cerebellar lobule formation J:87408
abnormal cerebellar Purkinje cell layer J:87408
abnormal cerebellum development J:87408
abnormal cerebellum external granule cell layer morphology J:87408
abnormal cerebellum vermis morphology J:87408
abnormal Purkinje cell dendrite morphology J:87408
ataxia J:87408
decreased Purkinje cell number J:87408
postnatal lethality, incomplete penetrance J:87408
small cerebellum J:87408
thin cerebellar molecular layer J:87408
Numbtm1Zili/Numbtm1Zili
Tg(Vil1-cre/ERT2)23Syr/?
involves: 129/Sv * C57BL/6 		abnormal intestinal cholesterol absorption J:226578
decreased circulating cholesterol level J:226578
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory