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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gdnf
glial cell line derived neurotrophic factor
MGI:107430
73 phenotypes from 7 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gdnftm1(cre/ERT2)Cos/Gdnftm1(cre/ERT2)Cos
involves: 129S6/SvEvTac * C57BL/6J 		normal renal/urinary system phenotype J:206853
Gdnftm1.1Neas/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal cholinergic neuron morphology J:160727
decreased motor neuron number J:160727
normal muscle phenotype J:160727
Gdnftm1.1Neas/Gdnftm1.1Neas
Myf5tm3(cre)Sor/Myf5+
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL 		abnormal cholinergic neuron morphology J:160727
decreased motor neuron number J:160727
Gdnftm1Bbd/Gdnf+
involves: 129S1/Sv * C57BL/6 		absent kidney J:33809
absent ureteric bud J:33809
single kidney J:33809
small kidney J:206853
Gdnftm1Bbd/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3+
involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal cholinergic neuron morphology J:160727
decreased motor neuron number J:160727
Gdnftm1Bbd/Gdnftm1Bbd
involves: 129S1/Sv * C57BL/6 		abnormal superior cervical ganglion morphology J:33809
abnormal ureteric bud invasion J:33809
absent enteric neurons J:33809
absent kidney J:33809
absent ureteric bud J:33809
decreased motor neuron number J:33809
distended duodenum J:33809
neonatal lethality, complete penetrance J:33809
pyloric stenosis J:33809
Gdnftm1Bbd/Gdnftm1Jlob
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S1/Sv * C57BL/6 * CBA 		abnormal brain morphology J:139371
abnormal carotid body morphology J:139371
abnormal dorsal striatum morphology J:139371
abnormal locus ceruleus morphology J:139371
abnormal substantia nigra morphology J:139371
abnormal tegmentum morphology J:139371
abnormal ventral striatum morphology J:139371
decreased locomotor activity J:139371
Gdnftm1Lmgd/Gdnf+
B6.129-Gdnftm1Lmgd 		abnormal glomerular capillary endothelium morphology J:168650
abnormal podocyte morphology J:168650
abnormal renal corpuscle morphology J:103081
abnormal renal tubule morphology J:103081
normal cardiovascular system phenotype J:168650
decreased glomerular capillary number J:168650
decreased kidney weight J:168650
decreased nephron number J:103081, J:168650
decreased podocyte number J:168650
decreased renal glomerulus number J:103081
fused podocyte foot processes J:168650
increased compensatory renal growth J:168650
increased kidney cell proliferation J:168650
increased mean systemic arterial blood pressure J:103081
increased mesangial cell number J:168650
increased renal glomerulus basement membrane thickness J:168650
kidney cortex cyst J:103081
renal glomerulus hypertrophy J:103081, J:168650
renal interstitial fibrosis J:168650
normal renal/urinary system phenotype J:103081, J:168650
single kidney J:168650
tubulointerstitial nephritis J:103081
Gdnftm1Lmgd/Gdnf+
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) 		abnormal enteric ganglia morphology J:73922
abnormal myenteric nerve plexus morphology J:73922
abnormal submucous nerve plexus morphology J:73922
chronic constipation J:73922
distended stomach J:73922
intestinal hypoperistalsis J:73922
megacolon J:73922
preweaning lethality, incomplete penetrance J:73922
single kidney J:73922
Gdnftm1Lmgd/Gdnf+
either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ) 		abnormal kidney development J:33810
abnormal kidney morphology J:33810
abnormal ureteric bud morphology J:33810
impaired branching involved in ureteric bud morphogenesis J:33810
single kidney J:33810
small kidney J:33810
Gdnftm1Lmgd/Gdnf+
involves: 129/Sv * C57BL/6 		abnormal renal corpuscle morphology J:103800
decreased nephron number J:103800
decreased renal glomerulus number J:103800
normal growth/size/body region phenotype J:103800
impaired branching involved in ureteric bud morphogenesis J:103800
increased kidney weight J:103800
single kidney J:103800
small kidney J:103800
Gdnftm1Lmgd/Gdnftm1Lmgd
either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ) 		abnormal enteric cholinergic neuron morphology J:33810
abnormal kidney development J:33810
absent enteric neurons J:33810
absent kidney J:33810
absent ureteric bud J:33810
impaired branching involved in ureteric bud morphogenesis J:33810
intestinal hypoperistalsis J:33810
neonatal lethality, complete penetrance J:33810
Gdnftm1Rosl/Gdnf+
involves: 129S2/SvPas 		absent kidney J:122519
renal hypoplasia J:33808
single kidney J:33808
Gdnftm1Rosl/Gdnf+
involves: 129S2/SvPas * C57BL/6 		abnormal enteric ganglia morphology J:82456
abnormal enteric nervous system morphology J:82456
abnormal enteric neuron morphology J:82456
abnormal neurotransmitter secretion J:82456
intestinal hypoperistalsis J:82456
Gdnftm1Rosl/Gdnftm1Rosl
involves: 129S2/SvPas 		abnormal cranial ganglia morphology J:33808
abnormal innervation pattern to muscle J:110955
abnormal intestine morphology J:33808
abnormal metanephric mesenchyme morphology J:33808
abnormal motor neuron innervation pattern J:132854
abnormal muscle spindle morphology J:132854
abnormal ovary topology J:33808
abnormal spleen red pulp morphology J:33808
absent enteric neurons J:33808
absent kidney J:33808
absent ureter J:33808
absent ureteric bud J:33808
decreased motor neuron number J:132854
neonatal lethality, complete penetrance J:33808
small dorsal root ganglion J:33808
Gdnftm1Rosl/Gdnftm1Rosl
involves: 129S2/SvPas * CD-1 		abnormal innervation pattern to muscle J:78718
abnormal spinal cord lateral motor column morphology J:78718
abnormal spinal nerve morphology J:78718
Gdnftm2Bbd/Gdnf+
involves: 129S1/Sv * C57BL/6 		absent kidney J:33809
absent ureteric bud J:33809
single kidney J:33809
Gdnftm2Bbd/Gdnftm2Bbd
involves: 129S1/Sv * C57BL/6 		abnormal superior cervical ganglion morphology J:33809
abnormal ureteric bud invasion J:33809
absent enteric neurons J:33809
absent kidney J:33809
absent ureteric bud J:33809
decreased motor neuron number J:33809
distended duodenum J:33809
neonatal lethality, complete penetrance J:33809
pyloric stenosis J:33809
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11/19/2024
MGI 6.24 		The Jackson Laboratory