Lyst Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lyst
lysosomal trafficking regulator
MGI:107448

94 phenotypes from 24 alleles in 27 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lyst^bg-2Btlr/Lyst^bg-2Btlr C57BL/6J-Lyst^bg-2Btlr	abnormal NK cell physiology	J:133617
	diluted coat color	J:133617
	increased susceptibility to Herpesvirales infection	J:133617
Lyst^bg-2J/Lyst^bg-2J C3.Cg-Lyst^bg-2J/J	abnormal gait	J:15166
	abnormal metastatic potential	J:33522
	abnormal susceptibility to infection	J:147940
	decreased metastatic potential	J:33522
	decreased Purkinje cell number	J:15166
	decreased susceptibility to fungal infection	J:147940
	impaired balance	J:15166
	impaired swimming	J:15166
	paraparesis	J:15166
	tremors	J:15166
Lyst^bg-2J/Lyst^bg-2J Not Specified	abnormal eye pigmentation	J:65327
	decreased ear pigmentation	J:65327
	decreased eye pigmentation	J:65327
	decreased tail pigmentation	J:65327
	diluted coat color	J:65327
Lyst^bg-3Btlr/Lyst^bg-3Btlr C57BL/6J-Lyst^bg-3Btlr	diluted coat color	J:143165
Lyst^bg-4Btlr/Lyst^bg-4Btlr C57BL/6J-Lyst^bg-4Btlr	diluted coat color	J:215822
Lyst^bg-5Btlr/Lyst⁺ C57BL/6J-Lyst^bg-5Btlr	impaired macrophage phagocytosis	J:217864
Lyst^bg-5Btlr/Lyst^bg-5Btlr C57BL/6J-Lyst^bg-5Btlr	impaired macrophage phagocytosis	J:217864
Lyst^bg-6Btlr/Lyst^bg-6Btlr C57BL/6J-Lyst^bg-6Btlr	increased susceptibility to Herpesvirales infection	J:220065
Lyst^bg-7Btlr/Lyst^bg-7Btlr C57BL/6J-Lyst^bg-7Btlr	diluted coat color	J:231804
Lyst^bg-8Btlr/Lyst^bg-8Btlr C57BL/6J-Lyst^bg-8Btlr	diluted coat color	J:234242
Lyst^bg-8J/Lyst^bg-8J involves: DBA/2J	abnormal coat/hair pigmentation	J:30778
	diluted coat color	J:30778
	hypopigmentation	J:30778
Lyst^bg-9Btlr/Lyst^bg-9Btlr C57BL/6J-Lyst^bg-9Btlr	diluted coat color	J:234265
Lyst^bg-10Btlr/Lyst^bg-10Btlr C57BL/6J-Lyst^bg-10Btlr	diluted coat color	J:255206
Lyst^bg-10J/Lyst^bg-10J involves: C57BL/6J * LT/Sv * MA/My * TF/Le	abnormal eye pigmentation	J:30778
	abnormal skin pigmentation	J:30778
	decreased ear pigmentation	J:30778
	decreased eye pigmentation	J:30778
	decreased tail pigmentation	J:30778
	diluted coat color	J:30778
Lyst^bg-11Btlr/Lyst^bg-11Btlr C57BL/6J-Lyst^bg-11Btlr	diluted coat color	J:265211
Lyst^bg-11J/Lyst^bg-11J involves: C57BL/6J	abnormal coat/hair pigmentation	J:30778
	diluted coat color	J:30778
	hypopigmentation	J:30778
Lyst^bg-14J/Lyst^bg-14J C3Fe;B6-Lyst^bg-14J	diluted coat color	J:85200
Lyst^bg-16J/Lyst^bg-16J B6.129S7-Rag1^tm1Mom/J	abnormal eye pigmentation	J:107049
	abnormal skin pigmentation	J:107049
	decreased ear pigmentation	J:107049
	decreased tail pigmentation	J:107049
	diluted coat color	J:107049
Lyst^bg-18J/Lyst^bg-18J B6.Cg-Lyst^bg-18J/Boc	diluted coat color	J:222308
Lyst^bg-Btlr/Lyst^bg-Btlr C57BL/6J-Lyst^bg-Btlr	abnormal foot pigmentation	J:133616
	abnormal NK cell physiology	J:133616
	decreased ear pigmentation	J:133616
	decreased tail pigmentation	J:133616
	diluted coat color	J:133616
	increased susceptibility to bacterial infection	J:133616
	increased susceptibility to Herpesvirales infection	J:133616
Lyst^bg-grey/Lyst^bg-grey C57BL/6-Lyst^bg-grey	abnormal dermal layer morphology	J:106442
	abnormal dermal mast cell morphology	J:106442
	abnormal hair follicle melanocyte morphology	J:106442
	abnormal iris pigment epithelium	J:106442
	abnormal iris pigmentation	J:106442
	abnormal melanocyte morphology	J:106442
	abnormal melanosome morphology	J:106442
	abnormal retina layer morphology	J:106442
	abnormal retina pigment epithelium morphology	J:106442
	abnormal skin morphology	J:106442
	absent hair follicle melanin granules	J:106442
	diluted coat color	J:106442
	enlarged hair follicle melanin granules	J:106442
Lyst^bg-J/Lyst^bg-J C57BL/6J-Lyst^bg-J/J	abnormal anterior uvea morphology	J:173521
	abnormal eye anterior chamber morphology	J:173521
	abnormal gait	J:15166
	abnormal granulocyte morphology	J:34814
	abnormal iridocorneal angle	J:173521
	abnormal iris morphology	J:173521
	abnormal iris pigment epithelium	J:173521
	abnormal iris pigmentation	J:141035, J:173521
	abnormal iris stroma morphology	J:173521
	abnormal neutrophil morphology	J:34814
	abnormal vestibuloocular reflex	J:29747
	decreased lysosomal enzyme secretion	J:7327
	decreased macrophage cell number	J:34814
	decreased platelet ADP level	J:7327
	decreased platelet ATP level	J:7327
	decreased platelet serotonin level	J:7327
	decreased Purkinje cell number	J:15166
	impaired balance	J:15166
	impaired natural killer cell mediated cytotoxicity	J:34814
	impaired swimming	J:15166
	increased bleeding time	J:7327
	paraparesis	J:15166
	tremors	J:15166
	normal vision/eye phenotype	J:173521
Lyst^bg-Lac/Lyst^bg-Lac CBA/CaLac-Lyst^bg-Lac	abnormal eye pigmentation	J:29745
	abnormal lysosome morphology	J:29745
	absent NK T cells	J:29745
	decreased ear pigmentation	J:29745
	decreased eye pigmentation	J:29745
	decreased tail pigmentation	J:29745
	diluted coat color	J:29745
Lyst^bg-Lac/Lyst^bg-Lac involves: CBA/CaLac	decreased ear pigmentation	J:29745
	decreased tail pigmentation	J:29745
	diluted coat color	J:29745
Lyst^bg-slt/Lyst^bg-slt YZ57/Ch	abnormal choroid pigmentation	J:25388
	abnormal ciliary body pigmentation	J:25388
	abnormal iris pigmentation	J:25388
	abnormal retina pigmentation	J:25388
	delayed hair regrowth	J:83269
	diluted coat color	J:25388
	premature hair loss	J:83269
Lyst^bg/Lyst^bg B6.C3Rl-Lyst^bg	abnormal eosinophil morphology	J:5078
	abnormal hair shaft melanin granule shape	J:5078
	abnormal hippocampal mossy fiber morphology	J:4978
	abnormal hippocampus pyramidal cell layer	J:4978
	abnormal lymphocyte morphology	J:5078
	abnormal lysosome morphology	J:5338, J:5514
	abnormal melanocyte morphology	J:5078
	abnormal melanosome morphology	J:5078, J:5338
	abnormal neutrophil morphology	J:5078
	abnormal tumor susceptibility	J:6301
	abnormal type II pneumocyte morphology	J:110157
	abnormal urine enzyme level	J:5590
	abnormal vestibuloocular reflex	J:29747
	accumulation of giant lysosomes in kidney/renal tubule cells	J:5590
	alveolitis	J:110157
	atelectasis	J:110157
	decreased cytotoxic T cell cytolysis	J:6692
	decreased lysosomal enzyme secretion	J:5590
	ectopic Bergmann glia cells	J:4978
	ectopic cerebellar granule cells	J:4978
	ectopic hippocampus pyramidal cells	J:4978
	ectopic Purkinje cell	J:4978
	enhanced behavioral response to xenobiotic	J:29294
	enlarged alveolar lamellar bodies	J:110157
	enlarged melanosome	J:5338
	impaired natural killer cell mediated cytotoxicity	J:6213, J:6302
	increased incidence of induced tumors	J:6302
	increased kidney weight	J:5590
	lysosomal protein accumulation	J:5590
	overexpanded pulmonary alveolus	J:110157
	pulmonary fibrosis	J:110157
Lyst^bg/Lyst^bg B6.C3Rl-Lyst^bg/J	abnormal lung development	J:149728
	abnormal lysosome morphology	J:6629
	abnormal lysosome physiology	J:6801
	abnormal NK cell physiology	J:6801
	emphysema	J:149728
	impaired lung alveolus development	J:149728
	increased susceptibility to parasitic infection	J:6946
Lyst^{tm1b(EUCOMM)Wtsi}/Lyst^{tm1b(EUCOMM)Wtsi} C57BL/6N-Lyst^{tm1b(EUCOMM)Wtsi}/Tcp	abnormal coat/hair pigmentation	J:211773
	abnormal iris morphology	J:211773
	abnormal retina morphology	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	increased grip strength	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	preweaning lethality, incomplete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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