Lyst Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lyst
lysosomal trafficking regulator
MGI:107448

49 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
a/a Hps6^ru-5J/Hps6^ru-5J Lyst^bg/Lyst^bg involves: C3H/Rl * C57BL/6J	abnormal coat/hair pigmentation	J:26546
	abnormal eye pigmentation	J:26546
	decreased eye pigmentation	J:26546
	diluted coat color	J:26546
a/a Hps6^ru/Hps6^ru Lyst^bg/Lyst^bg involves: C3H/Rl * C57BL/6J	abnormal melanogenesis	J:5346
	abnormal melanosome morphology	J:5346
	abnormal retina melanin granule morphology	J:5346
a/a Lyst^bg/Lyst^bg involves: C3H/Rl * C57BL/6J	abnormal choroid melanin granule morphology	J:5346
a/a Lyst^bg/Lyst^bg involves: C3H/Rl * C57BL/6J	abnormal retina melanin granule morphology	J:5346
a/a Lyst^bg/Lyst^bg Oca2^p-J/Oca2^p-J involves: C3H/HeJ * C3H/Rl * C57BL/6J	abnormal choroid melanin granule morphology	J:5346
	abnormal melanosome morphology	J:5346
a/a Lyst^bg/Lyst^bg Tyr^c/Tyr^c involves: C3H/Rl * C57BL/6J	abnormal choroid melanin granule morphology	J:5346
	abnormal melanogenesis	J:5346
	abnormal melanosome morphology	J:5346
	abnormal retina melanin granule morphology	J:5346
a/a Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b involves: C3H/Rl * C57BL/6J	abnormal choroid melanin granule morphology	J:5346
	abnormal retina melanin granule morphology	J:5346
A/? Lyst^bg/Lyst^bg Tyrp1⁺/? Not Specified	abnormal eye pigmentation	J:29744
	decreased ear pigmentation	J:29744
	decreased tail pigmentation	J:29744
	diluted coat color	J:29744
	irregular coat pigmentation	J:29744
A/? Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b Not Specified	decreased eye pigmentation	J:29744
A/? Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b Not Specified	diluted coat color	J:29744
Ednrb^s/Ednrb^s Lyst^bg-slt/Lyst^bg-slt involves: C57BL/10Ch * Y257/Ch	abnormal eye pigmentation	J:25388
Foxq1^sa/Foxq1^sa Lyst^bg/Lyst^bg involves: 101/Rl * C3H/Rl * C57BL10/Rl	enlarged spleen	J:5311
	interstitial pneumonia	J:5311
	lung inflammation	J:5311
	weight loss	J:5311
Foxq1^sa/Foxq1^sa Lyst^bg/Lyst^bg involves: 101/Rl * C3H/Rl * C57BL/6J * C57BL10/Rl	enlarged lymph nodes	J:5311
	increased lymphoma incidence	J:5311
	increased susceptibility to infection	J:5311
	interstitial pneumonia	J:5311, J:15166
	premature death	J:15166
Hps6^ru/Hps6^ru Lyst^bg-slt/Lyst^bg-slt involves: YZ57/Ch	decreased eye pigmentation	J:25388
Hps6^ru/Hps6^ru Lyst^bg-slt/Lyst^bg-slt involves: YZ57/Ch	diluted coat color	J:25388
Lyst^bg-J/Lyst^bg-J Prkdc^scid/Prkdc^scid B6.Cg-Lyst^bg-J Prkdc^scid/Sz	abnormal complement pathway	J:34814
	abnormal granulocyte morphology	J:34814
	abnormal level of surface class II molecules	J:34814
	abnormal lymph node morphology	J:34814
	abnormal neutrophil morphology	J:34814
	abnormal Peyer's patch morphology	J:34814
	abnormal spleen white pulp morphology	J:34814
	abnormal thymus morphology	J:34814
	decreased B cell number	J:34814
	decreased CD4-positive, alpha-beta T cell number	J:34814
	decreased CD8-positive, alpha-beta T cell number	J:34814
	decreased immunoglobulin level	J:34814
	decreased lymphocyte cell number	J:34814
	decreased pre-B cell number	J:34814
	decreased T cell number	J:34814
	impaired natural killer cell mediated cytotoxicity	J:34814
	increased eosinophil cell number	J:34814
	increased granulocyte number	J:34814
	increased macrophage cell number	J:34814
	increased monocyte cell number	J:34814
	increased neutrophil cell number	J:34814
	increased NK cell number	J:34814
	small Peyer's patches	J:34814
	small thymus	J:34814
	spleen hypoplasia	J:34814
	thymus cyst	J:34814
Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d involves: CT/Ch * YZ57/Ch	diluted coat color	J:25388
	normal vision/eye phenotype	J:25388
Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b involves: CT/Ch * YZ57/Ch	abnormal hair cycle	J:83269
	delayed hair regrowth	J:83269
	diluted coat color	J:83269
	premature hair loss	J:83269
Lyst^bg-slt/Lyst^bg-slt Oca2^p/Oca2^p involves: CT/Ch * YZ57/Ch	abnormal eye pigmentation	J:25388
	diluted coat color	J:25388
Lyst^bg/Lyst^bg Prkdc^scid/Prkdc^scid Not Specified	increased susceptibility to infection	J:4752

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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